What is Sperm DNA Fragmentation?
Sperm DNA fragmentation is the presence of aberrant genetic material inside sperm cells. During fertilization, the health of the genetic material contained within a sperm cell is critical. Healthy fertilization cannot occur if the genetic material within the sperm cells is destroyed. A Sperm DNA fragmentation test is essential to assess male fertility since a standard Semen Analysis test cannot identify the status of the genetic material at the molecular level. The COMET test, TUNEL test, Sperm chromatin dispersion test, and Sperm chromatin structure analysis are some of the most frequent sperm DNA fragmentation assays.
What is the use of sperm DNA fragmentation?
The Sperm DNA fragmentation test is used to determine male fertility. It is frequently combined with a sperm analysis test so that numerous characteristics such as sperm motility, sperm count, sperm volume, and DNA fragmentation may be analyzed simultaneously to offer a full report to the patient. It is a non-invasive and painless test.
What is the need for Sperm DNA Fragmentation?
If you are a sub-fertile or infertile male, sperm DNA fragmentation could help you understand how successful you will be at assisted reproduction techniques like in-vitro-fertilization. However, even if you aren’t sub-fertile or infertile, it is important to check for sperm DNA fragmentation at least once to know your level of fertility.
For a healthy male with active reproductive health, a sperm DNA fragmentation test may not be required. This test is frequently necessary for males at a higher risk of developing infertility. This painless technique, on the other hand, has no negative effects and is hence advised for all males.
What happens during Sperm DNA Fragmentation?
Sperm DNA fragmentation occurs when genetic material in the strands of DNA contained inside your sperm cells changes or is deleted. This may cause you to become infertile or subfertile. You must supply a sperm sample for a sperm DNA fragmentation test so that the doctor may analyse it for fragmentation.
Understanding the Sperm DNA Fragmentation Test results?
If you want to know how to interpret Sperm DNA fragmentation test results, check for the fragmentation %. A fragmentation percentage of 15 or less indicates that your sperm DNA is in good shape. Nevertheless, 15-25% suggests your sperm DNA is substantially fragmented, and fragmentation beyond 40% is cause for worry.