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Indomethacin

indomethacin

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By Medicover Hospitals / 16 Feb 2021
Home | Medicine | Indomethacin

What is Indomethacin?

  • The oral capsule of Indomethacin is a prescription medication and is only available as a generic drug. It's also available as a rectal suppository and as an oral liquid. Indomethacin is an anti-inflammatory, non-steroidal drug (NSAID). For the treatment of mild to extreme osteoarthritis, rheumatoid arthritis, gouty arthritis, or ankylosing spondylitis, indomethacin is used.
    1. Indomethacin Uses
    2. Indomethacin Side effects
    3. Precautions
    4. Indomethacin Overdose
    5. Indomethacin Storage
    6. Indomethacin vs Ibuprofen
    7. Frequently Asked Questions
    8. Citations

    Indomethacin Uses:

  • Indomethacin is used to alleviate inflammation, gout, bursitis, tendonitis-induced discomfort, swelling, and joint stiffness. It is also used to alleviate pain from other conditions that are different. It works by blocking the development of certain natural substances that cause inflammation in the body. If you are treating a chronic disease such as arthritis, ask your doctor for non-drug therapies and other drugs to treat the pain. This effect helps alleviate swelling and pain.
  • Indomethacin Side Effects:

  • Some of the common side effects of Indomethacin are:
    • Headache
    • Dizziness
    • Vomiting
    • Diarrhea
    • Constipation
    • Irritation of the rectum
  • Some of the serious side effects of Indomethacin are:
    • Shortness of breath
    • Swelling of the abdomen
    • Fever
    • Blisters
    • Rash
    • Hives
    • Hoarseness
    • Pale skin
    • Fast heartbeat
    • Nausea
    • Back pain
    • Painful urination
    • Blurred vision
    • If you have any of these serious symptoms immediately contact your doctor for further assistance. In any case, due to Indomethacin if you get any kind of reactions in your body try avoiding it.
    • A doctor advised you to take the medicines by seeing your problems and the benefits of this medicine are greater than the side effects. Majority of the people who use this medicine don’t show any side effects. Get medical help immediately if you get any serious Indomethacin side effects.

    Precautions:

  • Before taking Indomethacin talk with your doctor if you are allergic to it or any other medications. The product may contain some inactive ingredients which can cause some serious allergic reactions and other serious problems.
  • Before using the Indomethacin talk with your doctor if you are having any medical history especially:
    • Asthma
    • Bleeding or clotting problems
    • Heart disease
    • High blood pressure
    • Liver disease
    • Esophagus problems
    • Stroke

    How to take Indomethacin?

  • Indomethacin comes as a tablet, a capsule of sustained-release (long-acting) and a suspension to be taken orally and used rectally as a suppository. The capsules of indomethacin and liquid are typically taken two to four times a day. Indomethacin suppositories are usually given two to four times a day. Extended-release capsules are normally administered once or twice a day.
  • Swallow the entire capsules of extended-release; do not cut, chew, or crush them. To mix the drug equally, shake the suspension well before each application.
  • Dosage Forms and Strengths

  • Generic:
    • Form: oral immediate-release capsule
    • Strengths: 25 mg and 50 mg
    • Form: oral extended-release capsule
    • Strengths: 75 mg
  • Dosage for moderate to severe Rheumatoid Arthritis
  • Adult Dosage: The medication should be taken 2 to 3 times a day of 25 mg.
  • Dosage for moderate to severe Ankylosing Spondylitis
  • Adult dosage: The medication should be taken 2 to 3 times a day.
  • Missed Dose:

  • Missing one or two-dose of Indomethacin won’t show any effect on your body. The skipped dose causes no problem. But with some medication, it won’t work if you don’t take the dosage on time. If you miss a dose some sudden chemical change may affect your body. In some cases, your doctor would advise you to take the prescribed medicine as soon as possible if you have missed the dose.
  • Overdose:

  • Overdose of a drug can be accidental. If you have taken more than the prescribed Indomethacin tablets there is a chance of getting a harmful effect on your body’s functions. Overdose of a medicine can lead to some medical emergency.
  • Warnings for some Serious Health Conditions:

  • For people with Heart Conditions:
  • Indomethacin can increase your risk of developing a stroke or heart attack. Higher blood pressure levels can also be caused by it.
  • For people with Stomach Problems:
  • Indomethacin can increase your risk of stomach and bowel swelling or bleeding. It can increase the risk of ulcers as well.
  • For people with Kidney Problems:
  • When you take Indomethacin, the kidneys cannot function as well. The kidneys may be damaged or blood flow to your kidneys may be reduced.
  • Storage:

  • Direct contact with heat, air and light may damage your medicines. The exposure of medicine may cause some harmful effects. The medicine must be kept in a safe place and out of children’s reach.
  • Mainly the drug should be kept at room temperature between 68ºF and 77ºF (20ºC and 25ºC).
  • Before taking Indomethacin consult your Doctor. In case if you face any problems or get anyside effects after taking Indomethacin rush immediately to your nearby hospital or consult your doctor for better treatment. Carry your medications always in your bag while travelling to avoid any immediate emergencies. Follow your prescription and follow your Doctor advice whenever you take Indomethacin.
  • Indomethacin vs Ibuprofen:

    Indomethacin
    Ibuprofen
    The oral capsule of Indomethacin is a prescription medication and is only available as a generic drug. It's also available as a rectal suppository and an oral liquid. Ibuprofen is used for relieving the symptoms of arthritis, fever and menstrual types of pain. This is a non-steroidal anti-inflammatory drug.
    Indomethacin is used to alleviate inflammation, gout, bursitis, and tendonitis-induced discomfort, swelling, and joint stiffness. The medication is used for relieving the pain from various conditions like headache, dental pain, menstrual cramps and arthritis.
    Some of the common side effects of Indomethacin are:
    • Headache
    • Dizziness
    • Vomiting
    • Diarrhea
    • Constipation
    Some of the common side effects of Ibuprofen are:
    • Diarrhea
    • Nausea
    • Vomiting
    • Dizziness
    • Bloating
    • Edema

    Frequently Asked Questions:

    Indomethacin is used to relieve mild to the extreme pain, tenderness, swelling, and stiffness caused by osteoarthritis (arthritis caused by joint lining breakdown), rheumatoid arthritis (arthritis caused by joint lining swelling) and ankylosing spondylitis.
    Indomethacin is an anti-inflammatory drug and is much better than ibuprofen. So, 50 mg Indomethacin is much stronger than 600 mg of ibuprofen.
    Some may feel dizzy, lightheaded, drowsy, or less alert than they typically are because of this medication. Even if taken at bedtime, some people can feel drowsy or less alert when they awaken.
    Indomethacin is an anti-inflammatory non-steroidal drug (NSAID) that decreases fever, pain and inflammation. Ibuprofen (Motrin) and naproxen are similar (Naprosyn, Aleve). Indomethacin acts by reducing prostaglandin production.
    There might be an upset stomach, heartburn, headache, drowsiness or dizziness. Tell your physician or pharmacist immediately if any of these symptoms persist or worsen.

    Citations:

  • Indomethacin , https://n.neurology.org/content/43/8/1609.short
  • Indomethacin in the Treatment , https://www.nejm.org/doi/full/10.1056/NEJM198808113190602