Indomethacin's oral capsule is a prescription medication. It is only available as a generic drug. It's also available as a rectal suppository and an oral liquid.

Indomethacin is an anti-inflammatory, non-steroidal drug (NSAID). Indomethacin is used to treat these conditions:

  • Extreme osteoarthritis
  • Rheumatoid arthritis
  • Gouty arthritis
  • Ankylosing spondylitis.

Indomethacin Tablet Uses

  • Indomethacin is used to alleviate inflammation, gout, bursitis, tendonitis-induced discomfort, swelling, and joint stiffness.
  • It is also used to alleviate pain from other conditions that are different. It works by blocking the development of certain natural substances that cause inflammation in the body.
  • If you are treating a chronic disease such as arthritis, ask your doctor for non-drug therapies and other drugs to treat the pain. These treatments help alleviate swelling and pain.

Quick Highlight of Its Benefits:

  • Strong anti-inflammatory and analgesic effects
  • Reduces joint pain and swelling
  • Effective for acute gout and inflammatory arthritis flares

Dosage Forms and Strengths

Generic Dose

  • Form: Oral immediate-release capsule
  • Strengths: 25 mg and 50 mg
  • Form: Oral extended-release capsule
  • Strengths: 75 mg

Dosage for moderate to severe Rheumatoid Arthritis

Adult Dosage: The medication'should be taken 2 to 3 times a day of 25 mg.

Dosage for moderate to severe Ankylosing Spondylitis

Adult dosage: The medication'should be taken 2 to 3 times a day.

Missed Dose

Missing one or two doses of Indomethacin won't have any effect on your body. The skipped dose causes no problem. But with some medication, it won't work if you don't take the dosage on time.

If you miss a dose some sudden chemical change may affect your body. In some cases, your doctor would advise you to take the prescribed medicine as soon as possible if you have missed the dose.

Overdose

Overdose of a drug can be accidental. If you have taken more than the prescribed Indomethacin tablets there is a chance of getting a harmful effect on your body's functions.

Overdose of a medicine can lead to some medical emergency.

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Indomethacin Side Effects

Some of the common side effects of Indomethacin are:

Some of the serious side effects of Indomethacin are:

  • Shortness of breath
  • Swelling of the abdomen
  • Fever
  • Blisters
  • Rash
  • Hives
  • Hoarseness
  • Pale skin
  • Fast heartbeat
  • Nausea
  • Back pain
  • Painful urination
  • Blurred vision

If you have any of these serious symptoms, immediately contact your doctor for further assistance. In any case, if you get any kind of reaction in your body due to Indomethacin, try avoiding it.

A doctor advised you to take the medicines after seeing your problems and the benefits of this medicine, which are greater than the side effects.

The majority of the people who use this medicine don't show any side effects. Get medical help immediately if you get any severe Indomethacin side effects.

Precautions and Warnings of Indomethacin

Before taking Indomethacin, talk with your doctor if you are allergic to it or any other medications.

The product may contain some inactive ingredients, which can cause serious allergic reactions and other serious problems.

Before using the Indomethacin talk with your doctor if you have any medical history especially:

  • Asthma
  • Bleeding or clotting problems
  • Heart disease
  • High blood pressure
  • Liver disease
  • Esophagus problems
  • Stroke

Warnings for some Serious Health Conditions

For people with Heart Conditions:

Indomethacin can increase your risk of developing a stroke or heart attack. Higher blood pressure levels can also be caused by it.

For people with Stomach Problems:

Indomethacin can increase your risk of stomach and bowel swelling or bleeding. It can increase the risk of ulcers as well.

For people with Kidney Problems:

When you take Indomethacin, your kidneys cannot function as well. They may be damaged, or blood flow to your kidneys may be reduced.

Are There Any Age Restrictions for Using Indomethacin?

  • Approved for adults
  • May be used in children (especially IV form for PDA) under medical supervision
  • Elderly patients should be monitored closely due to increased risk of side effects

Alcohol or Food Interactions

  • Avoid alcohol - Increases risk of stomach bleeding
  • Take with food or milk to reduce stomach upset

Possible Interactions with Other Medications

May Interact With:

  • Other NSAIDs or aspirin (increased bleeding risk)
  • Blood thinners (e.g., warfarin)
  • ACE inhibitors and diuretics (reduced kidney function)
  • Lithium (increased lithium levels)
  • Methotrexate (increased toxicity)

Always inform your doctor of all medications and supplements you are taking.

How to Take Indomethacin?

  • Indomethacin comes as a tablet, a sustained-release (long-acting) capsule, and a suspension to be taken orally and used rectally as a suppository.
  • The capsules of indomethacin and liquid are typically taken two to four times a day.
  • Indomethacin suppositories are usually given two to four times a day, and extended-release capsules are normally administered once or twice a day.
  • Swallow the extended-release capsules whole; do not cut, chew, or crush them. Shake the suspension well before each application to mix the drug equally.

Storage

  • Direct contact with heat, air, and light may damage your medicines. Exposure to medicine may cause some harmful effects. The medicine must be kept in a safe place and out of children's reach.
  • Mainly, the drug should be kept at room temperature between 68ºF and 77ºF (20ºC and 25ºC).
  • Before taking Indomethacin, consult your Doctor. If you face any problems or get any side effects after taking Indomethacin, rush immediately to your nearest hospital or consult your doctor for better treatment.
  • Carry your medications in your bag while travelling to avoid any immediate emergencies. Follow your prescription and your Doctor's advice whenever you take Indomethacin.

What Happens If Not Stored Properly?

  • Loss of potency
  • Possible degradation of the medication

Indomethacin vs Ibuprofen

Indomethacin Ibuprofen
The oral capsule of Indomethacin is a prescription medication and is only available as a generic drug. It's also available as a rectal suppository and an oral liquid. Ibuprofen is used for relieving the symptoms of arthritis, fever and menstrual types of pain. This is a non-steroidal anti-inflammatory drug.
Indomethacin is used to alleviate inflammation, gout, bursitis, and tendonitis-induced discomfort, swelling, and joint stiffness. The medication is used for relieving the pain from various conditions like headache, dental pain, menstrual cramps and arthritis.
Some of the common side effects of Indomethacin are:
  • Headache
  • Dizziness
  • Vomiting
  • Diarrhea
  • Constipation
Some of the common side effects of Ibuprofen are:
  • Diarrhea
  • Nausea
  • Vomiting
  • Dizziness
  • Bloating
  • Edema

References

Clinical trial of indomethacin in Alzheimer's disease
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Frequently Asked Questions

Indomethacin is an anti-inflammatory drug and is much better than ibuprofen. So, 50 mg Indomethacin is much stronger than 600 mg of ibuprofen.

Some may feel dizzy, lightheaded, drowsy, or less alert than they typically are because of this medication. Even if taken at bedtime, some people can feel drowsy or less alert when they awaken.

Indomethacin is an anti-inflammatory non-steroidal drug (NSAID) that decreases fever, pain and inflammation. Ibuprofen (Motrin) and naproxen are similar (Naprosyn, Aleve). Indomethacin acts by reducing prostaglandin production.

There might be an upset stomach, heartburn, headache, drowsiness or dizziness. Tell your physician or pharmacist immediately if any of these symptoms persist or worsen.

Yes, it should be taken with food, milk, or an antacid to reduce stomach irritation.

Long-term use should be monitored by a doctor due to potential risks to the stomach, kidneys, and cardiovascular system.

Yes, it is often prescribed for short-term use during acute gout flare-ups due to its strong anti-inflammatory effects.

Alcohol should be limited, as combining it with NSAIDs increases the risk of stomach bleeding


Disclaimer: The information provided is accurate and up-to-date to the best of our knowledge. However, it should not be considered a substitute for medical advice or consultation. We do not guarantee its completeness or accuracy. The absence of specific warnings does not mean a medicine is safe for all users. We are not responsible for any outcomes based on this information and strongly recommend consulting a doctor for any medical concerns or questions.

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