Phenergan Syrup (promethazine) is a first‑generation antihistamine with powerful antiemetic and sedative properties. Widely used to treat allergy symptoms, prevent motion sickness, and control nausea or vomiting, it requires careful dosing across different age groups.
In this guide, we’ll explore its primary uses, recommended dosages, and important side effects to ensure safe, effective relief.
What is Phenergan Syrup?
Phenergan Syrup, also known by its generic name promethazine, is an antihistamine. It works by blocking the effects of histamine, a substance in the body that causes allergic symptoms. This syrup is often used to treat various conditions, including allergies, nausea, and even coughing.
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Phenergan Syrup has a wide range of applications. Here are some of its primary uses:
Allergies
Phenergan Syrup is commonly used to treat allergic reactions, including hay fever, allergic rhinitis, and other allergic conditions. It can relieve symptoms such as a runny nose, itching, and sneezing.
Motion Sickness
If you suffer from motion sickness, Phenergan Syrup can be a lifesaver. It helps prevent and treat nausea, vomiting, and dizziness caused by motion sickness.
Cough and Cold Symptoms
Phenergan Syrup IP is also effective in alleviating symptoms of cough and cold. It works as a cough suppressant and can help reduce the frequency and intensity of coughing. Learn more about Phenergan Syrup - used for cough.
Sedative
In some cases, Phenergan Syrup is used as a sedative to help individuals relax and sleep. This can be particularly beneficial for patients who struggle with sleep due to various conditions.
Nausea and Vomiting
Phenergan Syrup is effective in treating nausea and vomiting caused by different conditions, including post-surgery recovery and chemotherapy.
Phenergan Syrup Dose for Children
Proper dosing is crucial for children. It's also important to follow medical advice to ensure the medication's safety and effectiveness.
Phenergan Syrup Dosage for Children
The dosage of Phenergan Syrup for children varies depending on their age and the condition being treated. Here is a general guideline:
Children aged 2-5 years: The usual dose is 5 milligrams (mg) per dose, taken every 4 to 6 hours.
Children aged 6-12 years: The usual dose is 10 mg per dose, taken every 4 to 6 hours.
For children over 12 years: The usual dose is 12.5 to 25 mg per dose, taken every 4 to 6 hours.
It's essential to consult a healthcare provider for the exact dosage for your child.
Phenergan Syrup for Newborn Babies
Phenergan Syrup is generally not recommended for newborn babies due to the risk of severe side effects. Always consult a healthcare provider before administering any medication to a newborn.
Phenergan Syrup Uses for Babies
While Phenergan Syrup can be used for children, its use in babies requires special consideration. Here are some scenarios where it might be used:
Allergies
In some cases, Phenergan Syrup may be prescribed to treat severe allergic reactions in babies. However, this should only be done under strict medical supervision.
Cough
Phenergan syrup might be considered for babies with persistent coughs. Again, to ensure safety, this should be done under the guidance of a healthcare provider.
Depressing the vestibular system in the brain prevents nausea and motion sickness.
Exerting anticholinergic effects, which add to its anti‑nausea action (and cause dry mouth, blurred vision).
Weakly blocking D₂ dopamine receptors in the brain’s vomiting centre, boosting its antiemetic effect.
Phenergan Syrup vs Phenergan Tablets
Phenergan is available in both syrup and tablet forms. Each form has its advantages and is used based on the patient's needs.
Phenergan Syrup
Phenergan Syrup is often preferred for children or individuals who have difficulty swallowing tablets. It provides a flexible dosing option and can be easier to administer.
Phenergan Tablets
Phenergan tablets are convenient for adults and older children who can swallow pills. They provide a consistent dosage and are easy to carry and store.
Phenergan Injection
In some cases, Phenergan is administered via injection. This is usually done in a clinical setting for immediate relief of severe symptoms.
Nausea and vomiting that do not respond to oral medication
Preoperative sedation
Side Effects For Phenergan Syrup
Like all medications, Phenergan Syrup can cause side effects. Some are mild, while others may require medical attention.
Common Side Effects:
Drowsiness or sedation
Dry mouth
Dizziness
Blurred vision
Constipation
Serious Side Effects:
Respiratory depression (especially in young children)
Severe drowsiness or confusion
Hallucinations
Irregular heartbeat
Seizures
Important Considerations
While Phenergan Syrup is effective, there are some important considerations to keep in mind:
Side Effects
Like all medications, Phenergan Syrup can cause side effects. Common phenergan syrup side effects include drowsiness, dizziness, dry mouth, and blurred vision. Severe side effects are rare but can include respiratory distress and severe allergic reactions.
Drug Interactions
Phenergan Syrup can interact with other medications. To avoid potential interactions, it's important to inform your healthcare provider about all the medications you are taking.
Special Populations
Pregnant Women: Phenergan Syrup should be used with caution during pregnancy. Consult your healthcare provider for advice.
Elderly: Older adults may be more sensitive to the effects of Phenergan Syrup and may require adjusted dosages.
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Phenergan Syrup is a helpful medication used to treat conditions such as allergies, motion sickness, cough, and nausea. It's essential to determine the correct dose for each age group to use it safely.
Always talk to a doctor before starting this or any new medicine to make sure it’s right for you. When used correctly and under medical supervision, Phenergan Syrup can help alleviate symptoms and enhance your daily life.
Frequently Asked Questions
When used as prescribed, Phenergan is generally safe for allergies, nausea and motion sickness. Risks include sedation, respiratory depression in young children, anticholinergic effects, and interactions with other CNS depressants.
Promethazine interacts with CNS depressants (opioids, benzodiazepines, alcohol), anticholinergics (atropine), MAO inhibitors, and QT‑prolonging agents (e.g., sotalol), increasing sedation, anticholinergic burden, and arrhythmia risk.
Promethazine has a half‑life of about 10–19 hours. It typically takes around five half‑lives, roughly 2–4 days, for the drug to be mostly eliminated from the body, depending on individual metabolism.
Yes, weight gain can be a side effect of Phenergan in some people due to increased appetite or changes in metabolism.
The dose for children depends on age and weight. Only give Phenergan for sleep under a doctor’s guidance to avoid risks.
Alternatives include antihistamines like cetirizine or loratadine, but always check with a doctor to choose the safest option for your child.