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Silodosin

Silodosin

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By Medicover Hospitals / 09 April 2021
Home | Medicine | Silodosin

Silodosin

  • Silodosin is an alpha-adrenergic blocker that is used to improve urination in men with Benign prostatic hyperplasia. The medication is available in a prescription only. It comes in the shape of an oral capsule. Rapaflo is the brand name for the medication Silodosin oral capsule. Silodosin improves urinary symptoms and relieves bladder outlet obstruction by binding to α1A--adrenoceptors with high affinity and relaxing the lower urinary tract.
    1. Silodosin Uses
    2. Silodosin Side effects
    3. Precautions
    4. Dosage
    5. Warnings
    6. Storage
    7. Silodosin vs Tamsulosin
    8. Frequently Asked Questions
    9. Citations

    Silodosin Uses:

  • Men take silodosin to relieve the effects of an enlarged prostate (benign prostatic hyperplasia-BPH). It functions by relaxing the muscles in the prostate and bladder, rather than shrinking the prostate. This helps to alleviate BPH symptoms including trouble starting the flow of urine, a sluggish stream, and the need to urinate often or urgently. It belongs to the class of drugs known as alpha-blockers. Avoid using the medication for treating high blood pressure.
  • Side Effects:

  • Some of the common side effects of silodosin are:
    • Dizziness
    • Diarrhea
    • Orthostatic Hypotension
    • Headache
    • Retrograde ejaculation
    • Common cold
    • Stuffy nose
  • Some of the serious side effects of silodosin are:
    • Swelling of the face
    • Problem with breathing or swallowing
    • Skin rash
    • Itching
    • Hives
    • Peeling skin
    • Nausea
    • Liver problems
    • Vomiting
    • Loss of appetite
    • Stomach pain and swelling
    • Prolonged erection
  • Silodosin can cause some serious side effects and can lead to some serious health problems. If you are facing any of the above serious side effects. Talk with your doctor if you are having any serious problems.
  • Precautions:

  • Before taking silodosin talk with your doctor if you are allergic to it or any other medication-related to it. The product may contain some inactive ingredients which will cause a serious allergic reaction to it or any other medications. Before using the medication talk with your doctor if you have any medical history such as Kidney disease, Liver disease, Low blood pressure and eye problems (cataracts, glaucoma). Talk to your doctor if you are having any prescription or nonprescription medication, vitamins, nutritional supplements and herbal products you are taking or planning to take.
  • How to use silodosin?

  • Silodosin comes in the form of a capsule which should be taken orally. The medication should be taken with food once a day. Follow the instructions on your prescription label closely, and if there is something you don't understand, ask your doctor or pharmacist to explain it to you. Silodosin should be taken exactly as prescribed.
  • Drug forms and strengths

  • Generic: Silodosin
    • Form: oral capsule (4 mg and 8 mg)
  • Brand: Rapaflo
    • Form: oral capsule (4 mg and 8 mg)
  • Dosage for benign prostatic hyperplasia
  • Adult dosage (ages 18–64 years): 8mg tablet should be taken once per day with a meal.
  • Missed Dose

  • If you miss a dose, make sure to take it as soon as possible. If it's time for the next dose, skip the missed dose. Avoid taking two doses at a time as it can lead to some severe consequences.
  • Overdose

  • Overdose of a drug can be accidental. If you have taken more than the prescribed Silodosin tablets there is a chance of getting a harmful effect on your body’s functions. Overdose of a medicine can lead to some medical emergency.
  • Warnings for Some Serious Health Conditions

  • For people with Kidney Disease: Part of the way the body gets rid of this drug is through your kidneys. The drug can stay in your body if your kidneys aren't working properly. You're more likely to experience side effects as a result of this. If you have serious kidney disease, you should avoid taking this medication. Your doctor can recommend a lower dose if you have moderate kidney disease.
  • For people with Liver Disease: The medication is processed by the liver. More of the drug can stay in your body if your liver isn't working properly. You're more likely to experience side effects as a result of this. Since it hasn't been studied in people with serious liver disease, this drug isn't approved for them.
  • For people with Low pressure: This medication can cause low blood pressure, dizziness, and even further lowering of your blood pressure. Don't drive, operate equipment, or engage in risky activities until you understand how they can affect you.
  • Pregnancy: This medicine is used to treat male BPH. It isn't meant to be used on females. This medicine is listed as a pregnancy group B medication. This has two implications:
  • The drug hasn't been shown to affect the foetus in experiments on pregnant animals.
  • There are insufficient trials in pregnant women to prove that the medication is harmful to the foetus.
  • Breastfeeding: This medicine is used to treat male BPH. It isn't meant to be used on females. It is unknown whether this medication moves into breast milk.
  • Storage:

  • Direct contact with heat, air and light may damage your medicines. The exposure of medicine may cause some harmful effects. The medicine must be kept in a safe place and out of children’s reach.
  • Mainly the drug should be kept at room temperature between 68ºF and 77ºF (20ºC and 25ºC).
  • Silodosin vs Tamsulosin

    Silodosin
    Tamsulosin
    Silodosin is an alpha-adrenergic blocker which is used to improve urination in men with Benign prostatic hyperplasia. The medication is available in a prescription only. Tamusolin is an alpha-blocker which relaxes the muscles in the prostate and bladder neck which makes it easier for urinating.
    It functions by relaxing the muscles in the prostate and bladder, rather than shrinking the prostate. Tamsulosin is used by men for the treatment of an enlarged prostate. It doesn’t shrink the prostate but it works by relaxing the prostate and bladder.
    Some of the common side effects of silodosin are:
    • Dizziness
    • Diarrhea
    • Orthostatic Hypotension
    • Headache
    Some of the serious side effects of Tamsulosin are:
    • Painful erection of the penis which lasts for hours
    • Rash
    • Itching
    • Hives

    Frequently Asked Questions:

    Silodosin is an alpha-adrenergic (AL-fa ad-ren-ER-jik) blocker used to help men with benign prostatic hyperplasia urinate more easily (enlarged prostate). ). It functions by relaxing the muscles in the prostate and bladder, rather than shrinking the prostate. This helps to alleviate BPH symptoms including trouble starting the flow of urine, a sluggish stream, and the need to urinate often or urgently.
    Some of the common side effects of silodosin are:
    • Dizziness
    • Diarrhea
    • Orthostatic Hypotension
    • Headache
    Silodosin is the most potent AB with the quickest onset of action. Silodosin also enhances the quality of life in patients with BPH-related LUTS and increases the maximum flow rate objectively. Silodosin, on the other hand, has more side effects than tamsulosin and alfuzosin.
    Erectile function is normally unaffected by silodosin. The drug, on the other hand, may cause ejaculatory dysfunction and inability to ejaculate. If you have any adverse effects or are experiencing any uneasiness when taking this drug, call your doctor right away.
    Silodosin is normally taken once a day with a meal. It's best to take it at the same time every day. The dosage is decreased by the doctor in patients who have some form of kidney failure. If a patient is unable to swallow the pills, they should open them and sprinkle the powder on a tablespoon of applesauce. Drink a glass of this mixture right away, without chewing, within 5 minutes.

    Citations:

  • Silodosin, https://www.sciencedirect.com/science/article/abs/pii/S1569905610000539
  • Efficacy of silodosin, https://www.sciencedirect.com/science/article/abs/pii/S0302283814011658