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What is Perphenazine?

Perphenazine is an anti-psychotic drug called phenothiazine. The medication is used to treat schizophrenia-like psychiatric conditions. It is also used to manage nausea and vomiting, which are extreme. An antipsychotic derivative of phenothiazine with activities and applications close to those of chlorpromazine.

Perphenazine Uses

This medicine is being used to treat such mental/mood conditions (e.g., schizophrenia, manic phase of bipolar disorder, schizoaffective disorder). This medication allows you to think more clearly, feel less stressed, and engage in daily life. Aggressive actions and the urge to hurt yourself/ others can be decreased. Perphenazine is a psychological (antipsychotic-type) drug that works by helping to restore the balance in the brain of certain natural substances (e.g., dopamine).

Perphenazine Side effects

Some of the common side effects of Perphenazine are:

  • Pale Skin
  • Dry Mouth
  • Excess Saliva
  • Stuffed Nose
  • Headache
  • Nausea
  • Vomiting
  • Diarrhea
  • Constipation
  • Loss Of Appetite
  • Blank Facial Expression
  • Shuffling Walk

Some of the serious side effects of Perphenazine are:

  • Fever
  • Muscle Stiffness
  • Falling
  • Confusion
  • Fast Or Irregular Heartbeat
  • Sweating
  • Decreased Thirst
  • Neck Cramps
  • Rash
  • Hives
  • Itching
  • If you have any of these serious symptoms immediately contact your doctor for further assistance. In any case, due to Perphenazine if you get any kind of reactions in your body try avoiding it.
  • A doctor advised you to take the medicines by seeing your problems and the benefits of this medicine are greater than the side effects. Majority of the people who use this medicine don’t show any side effects. Get medical help immediately if you get any serious Perphenazine side effects.

    • Precautions

    Before taking Perphenazine talk with your doctor if you are allergic to it or any other medications. The product may contain some inactive ingredients which can cause some serious allergic reactions or some other problems.
    Before using the medication talk with your doctor if you are having any medical history such as:

    • Decreased bone marrow
    • Serious Head injury
    • Liver problems
    • Low blood pressure
    • Breathing problems
    • Breast cancer
    • Irregular heartbeat

    How to take Perphenazine?

    Take this medicine by mouth, usually with or without food or as recommended by your doctor, 1-3 times a day. The dosage is dependent on your medical condition and therapy reaction. Your doctor can order you to take a low dose at first, increasing the dose gradually to reduce the risk of side effects, such as muscle spasms. Carefully follow the directions of your doctor.

    Dosages

    Perphenazine:2 mg, 4 mg, 8 mg, 16 mg

    Missed Dose

    Missing one or two-dose of Perphenazine won’t show any effect on your body. The skipped dose causes no problem. But with some medication, it won’t work if you don’t take the dosage on time. If you miss a dose some sudden chemical change may affect your body. In some cases, your doctor would advise you to take the prescribed medicine as soon as possible if you have missed the dose.

    Overdose

    Overdose of a drug can be accidental. If you have taken more than the prescribed Perphenazine tablets there is a chance of getting a harmful effect on your body’s functions. Overdose of a medicine can lead to some medical emergency.

    Interactions

    Drug interactions can affect the working of your drugs or increase the risk of serious side effects. Not all potential drug interactions are included in this paper. Keep a list and share it with your doctor and pharmacist of all the medications you use (including prescription/nonprescription medicines and herbal products). Do not start, stop, or change the dosage of any drug without being treated by your doctor.
    Certain medicines used for Parkinson's disease (e.g., bromocriptine, levodopa, pergolide), some anticholinergic drugs (e.g., dicyclomine, scopolamine), medicines that affect liver enzymes that extract perphenazine from the body are several things that may interfere with this medicine (e.g., amiodarone, duloxetine, fluoxetine, paroxetine, ritonavir).

    Storage

    Direct contact with heat, air and light may damage your medicines. The exposure of medicine may cause some harmful effects. The medicine must be kept in a safe place and out of children’s reach.
    Mainly the drug should be kept at room temperature between 68ºF and 77ºF (20ºC and 25ºC).
    Before taking Perphenazine consult your Doctor. In case if you face any problems or get any side effects after taking Perphenazine rush immediately to your nearby hospital or consult your doctor for better treatment. Carry your medications always in your bag while travelling to avoid any immediate emergencies. Follow your prescription and follow your Doctor advice whenever you take Perphenazine.

    Perphenazine vs Fluphenazine

    Perphenazine

    Fluphenazine
    Perphenazine is an anti-psychotic drug called phenothiazine. The medication is used to treat schizophrenia-like psychiatric conditions. Fluphenazine is an antipsychotic drug called phenothiazine that is used to treat psychiatric conditions such as schizophrenia.
    Perphenazine is being used to treat such mental/mood conditions. This medication allows you to think more clearly, feel less stressed, and engage in daily life Fluphenazine belongs to a class of drugs known as phenothiazines, which are also known as neuroleptics. It works by affecting the brain's balance of natural chemicals (neurotransmitters)
    Some of the common side effects of Perphenazine are:
    • Pale Skin
    • Dry Mouth
    • Excess Saliva
    • Stuffed Nose
    • Headache
    • Nausea
    		 Some of the common side effects of fluphenazine are:
    • Upset stomach
    • Weakness or tiredness
    • Insomnia
    • Nightmares
    • Dry mouth

    Citations

    Cost-Effectiveness of Second-Generation Antipsychotics and Perphenazine in a Randomized Trial of Treatment for Chronic Schizophrenia | American Journal of Psychiatry
    Efficacy of the combination of fluoxetine and perphenazine in the treatment of psychotic depression.

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    Frequently Asked Questions

    What is the brand name for perphenazine?

    It is branded under the Trilafon and Etrafon/Triavil/Triptafen brands. Decentan is a brand name in Europe, meaning that perphenazine is around 10 times more potent than chlorpromazine.

    Does perphenazine help with anxiety?

    Perphenazine has a wide efficacy range. In patients with all forms of anxiety and agitation, from moderate stress or hyper-motricity to extreme psychosis or psychomotor hyperactivity, it tends to be useful.

    When should I take perphenazine?

    Take this medicine by mouth, usually with or without food or as recommended by your doctor, 1-3 times a day. Perphenazine dosage is dependent on the medical condition and the therapy reaction.

    Does perphenazine make you sleepy?

    There might be drowsiness, constipation, dry mouth, dizziness, blurred vision, exhaustion, or unexplained weight gain.

    What are the side effects of taking perphenazine?

    Some of the common side effects of Perphenazine are:

    • Pale Skin
    • Dry Mouth
    • Excess Saliva
    • Stuffed Nose
    • Headache
    • Nausea

    Disclaimer: The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not be treated as a replacement for physical medical consultation or advice. We do not guarantee the accuracy and the completeness of the information so provided. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company. We do not take any responsibility for the consequences arising out of the aforementioned information and strongly recommend you for a physical consultation in case of any queries or doubts.