Norethisterone is also known as norethindrone is a synthetic form of the female hormone progesterone which belongs to the 19-nortestosterone-derived progestin class. This is further classified as second-generation progestin, along with levonorgestrel and its derivatives, and is the active form of several other progestins, including norethynodrole and lynestrenol.

It is commonly used to treat menstrual problems, delay periods, and as a contraceptive.

What Are the Uses of Norethisterone Tablets?

Norethisterone (norethindrone) is a medication primarily used for preventing pregnancy, often referred to as the "mini-pill" due to its lack of estrogen. Its key uses include:

  • Prevents pregnancy by thickening cervical mucus and altering the uterus lining
  • Regulating menstrual cycles, including heavy or irregular periods
  • Delaying menstruation for special situations (e.g., travel, events)
  • Managing endometriosis by reducing pain and abnormal tissue growth
  • Treating abnormal vaginal bleeding not linked to serious medical issues
  • Used in hormone replacement therapy (HRT) alongside estrogen during menopause

How Does Norethisterone Work (Mechanism of Action)?

Norethisterone is a synthetic progestine. It works by imitating the effects of natural progesterone (female hormone) and the growth and shedding of the lining of the womb, thus treating menstrual irregularities.

  • Thickens cervical mucus, making it harder for sperm to reach the egg
  • Alters the uterine lining, reducing the chances of implantation
  • Suppresses ovulation in about half of menstrual cycles
  • Reduces the growth of the womb lining, which helps in conditions like endometriosis

How to Take Norethisterone Tablets?

Norethisterone tablets should be taken exactly as prescribed by your healthcare provider. Here are general guidelines on how to take them:

  • Dosage and Timing: For contraception, take one norethisterone tablet (usually 0.35 mg) daily at the same time each day. Do not exceed 24 hours between doses.
  • Menstrual Disorders or Abnormal Vaginal Bleeding: Typically taken for 5 to 10 days. Follow your doctor's instructions.
  • Endometriosis: Usually taken daily long-term, with the dose adjusted by your doctor. The initial dose is often 5 mg, which may be increased.

What Should I Do If I Miss a Dose of Norethisterone?

Missing a dose can reduce its effectiveness, especially for birth control.

  • If you miss a pill and are more than three hours late, take it as soon as you remember. For the next 48 hours, use a backup method of contraception.
  • Follow your doctor's directions. Take the missed dose as soon as you realise it, unless it is almost time for your next dose.

What Happens If I Take an Overdose?

In the case of an overdose, seek emergency medical treatment immediately or contact the Poison Help line.

  • An overdose is generally not expected to be dangerous, but it'still requires medical supervision.
  • Overdose may cause nausea, vomiting, or vaginal bleeding.

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What Are the Side Effects of Norethisterone Tablets?

Most people tolerate it well, but side effects can still occur in some cases.

Common Side Effects of Norethindrone

Serious (but rare) Side Effects

  • Blood clots
  • Vision changes
  • Severe headaches
  • Depression

If you have any of these serious symptoms, immediately contact your doctor for further assistance. In any case, due to Norethindrone, if you get any kind of reaction in your body, try avoiding it.

Precautions for Norethisterone

Before using Norethindrone, talk with your doctor if you are allergic to it or any other medications. The product may contain some inactive ingredients that can cause some serious allergic reactions or other severe problems.

Do Not Use If You

  • Are pregnant or planning pregnancy
  • Have a history of blood clots
  • Have liver disease or unexplained vaginal bleeding

Before using the medication talk with your doctor if you have any medical history such as:

Possible Interactions with Other Medications

Some medicines, supplements, and herbs can reduce the effectiveness or increase the side effects of norethisterone.

Potential Interactions

  • Antibiotics like rifampin
  • Anti-seizure drugs
  • St. John's Wort (herbal remedy)
  • HIV medications
  • Other hormonal products

Always tell your doctor about all medications and supplements you are taking.

How Should Norethisterone Be Stored?

Proper storage keeps the medicine effective and safe for use. Follow these tips to avoid contamination or loss of potency.

  • Store norethisterone tablets at room temperature (20-25°C)
  • Keep away from moisture, heat, and light.
  • Keep the medication in its original container
  • Keep out of reach of children.
  • Do not store in the bathroom.

Norethisterone vs Progesterone

Norethisterone Progesterone
Synthetic progestin derived from 19-nortestosterone A natural hormone produced by the ovaries
Has mild androgenic activity, which may cause side effects like acne or hair growth No androgenic activity; generally better tolerated
Usually taken orally; also available in injectable form Available in oral, vaginal, injectable, and transdermal forms
May cause mood swings, nausea, acne, or weight gain Side effects may include drowsiness, breast tenderness, or bloating

References

Full article: Acute pulmonary edema associated with naphazoline ingestion
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Frequently Asked Questions

Yes, Norethisterone tablets can be used to delay periods. This is typically done by starting the medication three days before the expected period and continuing until the delay is no longer needed.

Yes, Norethisterone tablets can be used to stop and delay your period. To delay your period, you should take Norethisterone tablets three times a day, starting three days before your expected period. This will delay your period until about three days after you have taken the last tablet.

Norethindrone is often used once daily for 5 to 10 days during the additional part of the scheduled menstrual cycle, as advised by the physician, to treat irregular uterine bleeding and stopped menstrual cycles. Withdrawal bleeding usually happens three to seven days after you stop using the medicine.

Yes, it is possible to get pregnant while taking Norethisterone because it does not prevent the fertilization of an egg. Unlike contraceptive pills, which inhibit ovulation, Norethisterone primarily works by altering the uterine lining and thickening cervical mucus.

Bleeding usually starts 2–4 days after stopping norethisterone, as hormone levels drop and your body resumes its natural cycle.

It may take 1-3 days for norethisterone to reduce or stop bleeding, depending on the cause and how your body responds to the medication.

To delay your period, start taking norethisterone 3 days before your expected period date, as directed by your doctor.


Disclaimer: The information provided is accurate and up-to-date to the best of our knowledge. However, it should not be considered a substitute for medical advice or consultation. We do not guarantee its completeness or accuracy. The absence of specific warnings does not mean a medicine is safe for all users. We are not responsible for any outcomes based on this information and strongly recommend consulting a doctor for any medical concerns or questions.

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