Natrise 15 Tablet is a prescription medicine used to treat low sodium levels in the blood, a condition known as hyponatremia. It also helps manage a rare kidney condition called autosomal dominant polycystic kidney disease (ADPKD). The generic name of natrise is Tolvaptan.

It is recommended that you should consult your doctor before discontinuing the use of this medication.

What Are the Uses of Natrise Tablet?

This medicine is mainly used to correct sodium imbalance and treat kidney-related issues effectively.

Natrise Tablet is commonly used to treat

  • Hyponatremia (low blood sodium levels)
  • Heart failure-related low sodium
  • Cirrhosis-related sodium imbalance
  • Syndrome of inappropriate antidiuretic hormone (SIADH).
  • Autosomal Dominant Polycystic Kidney Disease (ADPKD)

How Does Natrise Tablet Work (Mechanism of Action)?

This medicine works by helping the kidneys remove water without affecting sodium levels in the body.

Natrise contains Tolvaptan, a vasopressin V2-receptor antagonist. It blocks the action of a hormone (vasopressin) that causes water retention, thereby increasing urine flow and helping restore normal sodium levels in the blood.

How to use Natrise 15mg Dosage?

Follow your doctor's instructions carefully to get the best results and avoid unwanted side effects.

  • Natrise Tablet can be taken with or without food.
  • It is best to take it at the same time every day to maintain consistent levels in the body.

What Should I Do If I Miss a Dose of Natrise?

  • If you forget to take any dose or miss a dose by mistake, take it as soon as you recall it.
  • If it is already the time for the next dose, skip the forgotten dose. Take your next medicine on a regular schedule. Do not double the dose.

What Happens If I Overdose on Natrise?

If someone has taken an overdose of this medicine, it can be serious and may lead to serious complications. Take only what is prescribed to you by your doctor.

Symptoms of overdose may include:

  • Trouble breathing
  • Severe dehydration
  • Muscle weakness
  • Confusion or seizures

seek medical advice immediately in case of an overdose.

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What Are the Side Effects of Natrise 15mg Tablet?

While many people do not experience serious issues, some side effects can occur and need attention.

Common side effects of Natrise

Serious but rare side effects of Natrise

  • Excessively high sodium levels
  • Sweating
  • Mood changes
  • Trouble speaking or swallowing

Consult your doctor if any side effect worsens or becomes bothersome.

Precautions for Natrise

It's important to know when this medicine should be avoided or used cautiously.

  • Do not consume alcohol while taking the Natrise Tablet. Please consult your physician.
  • These tablets may not be safe to use during pregnancy. While human studies are limited, animal studies have shown potential harm to the developing baby.
  • Before prescribing, your doctor will properly study the benefits and potential risks. Please consult your physician. This medication is likely unsafe while breastfeeding.
  • As limited human data suggests it may pass into breast milk and harm the baby. It may also cause drowsiness, dizziness, or blurred vision, which can affect your alertness.
  • If you experience any of these, do not drive. Natrise Tablet is not harmful to patients with kidney disease. There is no need to adjust the dosage.
  • Natrise Tablet, on the other hand, is not recommended for patients with severe kidney disease.
  • Natrise Tablet should be used with caution in patients with liver disease. The dosage may need to be adjusted. It should not be used in patients with severe liver disease.

Possible Interactions with Other Medications

Every drug interacts differently with each individual. Before starting to take any medication, you should discuss all potential interactions with your doctor.

Grapefruit juice should not be consumed while taking this medication because it increases medicine's levels and risk of side effects.

Tell your doctor if you're taking:

  • Blood pressure medications
  • Diuretics
  • Antidepressants
  • Herbal supplements

How Should Natrise Tablet Be Stored?

Proper storage keeps the medicine safe and effective for longer.

  • The medicine should not come in direct contact with heat, air, or light, which may damage your medicines.
  • Exposure to medicine might cause some harmful effects or severe side effects. The medicine must be kept in a safe place and out of children's reach.

Important information

  • Natrise Tablet is used to treat low blood sodium levels. It also improves urine flow while preventing the body from losing too much sodium as you urinate.
  • Natrise Tablet should not be taken if you are unable to urinate, cannot sense thirst, or if you are severely dehydrated.
  • When you begin or restart Natrise Tablet treatment, you must be admitted to a hospital for observation.
  • Consult your doctor if you experience difficulties with your speech or muscle control, difficulty swallowing, difficulty moving your arms and legs, or mood changes.
  • Before beginning treatment, and on a regular basis thereafter, your doctor may perform a liver function test. Notify your doctor if you notice any of the following symptoms: yellowing of the eyes or skin, dark urine, or stomach pain.

Natrise vs Hyponat-O

Natrise Hyponat-O
Natrise 15 Tablet is used to treat hyponatremia and autosomal dominant polycystic kidney disease (ADPKD) Hyponat-O 15 Tablet is a vasopressin antagonist. Hyponat-O 15 Tablet is a medication used to treat low sodium levels in the blood.
Natrise Tablet is a vasopressin inhibitor used to treat low sodium levels in the blood. It is commonly prescribed for conditions like heart failure, liver cirrhosis, and SIADH (syndrome of inappropriate antidiuretic hormone secretion). It is used to treat low sodium levels in the blood, which can be caused by conditions like heart failure, liver cirrhosis, or SIADH (syndrome of inappropriate antidiuretic hormone).
It works by interfering with the action of the hormone vasopressin in the body. It works by inhibiting the action of the hormone vasopressin in the body. This increases urine production, decreases the amount of water in the blood, and raises the blood sodium level.
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Frequently Asked Questions

Natrise Tablet is used to lower sodium levels in the blood. Natrise Tablet should not be taken for more than 30 days, even if the doctor has prescribed the dose and duration. After consulting with a doctor, it is possible to discontinue the treatment once the sodium levels have returned to normal.

Yes, Natrise Tablet can cause an increase in blood sugar levels. As a result, patients with diabetes mellitus should exercise extreme caution when taking Natrise Tablet and should monitor their blood sugar levels on a regular basis.

Natrise Tablet should not be taken if you have low sodium levels, are unable to replace fluids through drinking, are unable to tell when you are thirsty, dizzy, or feeling faint, or if your kidneys are not working properly due to excessive fluid loss. You should also avoid Natrise Tablet if your body is unable to produce urine, if you are allergic to Natrise Tablet, or if you are taking certain medications that interfere with Natrise Tablet's effectiveness.

No, grapefruit or grapefruit juice should not be consumed while taking Natrise Tablet. The reason for this is that grapefruit or grapefruit juice may raise Natrise Tablet levels in your blood, causing your sodium levels to rise too quickly.

Natrise Tablet is not harmful to patients with kidney disease. There is no need to adjust the Natrise Tablet dosage. Natrise Tablet, on the other hand, is not recommended for patients with severe kidney disease.

There are no direct natural alternatives to Natrise. However, managing fluid intake and treating the underlying cause of low sodium may help under medical supervision.

Both Natrise and Samsca treat low sodium, but they contain different active ingredients. Natrise has Tolvaptan; Samsca is the brand name of Tolvaptan in some regions.

This medicine is generally prescribed for adults only. Safety and effectiveness in children have not been well established.


Disclaimer: The information provided is accurate and up-to-date to the best of our knowledge. However, it should not be considered a substitute for medical advice or consultation. We do not guarantee its completeness or accuracy. The absence of specific warnings does not mean a medicine is safe for all users. We are not responsible for any outcomes based on this information and strongly recommend consulting a doctor for any medical concerns or questions.

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