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Modafinil

modafinil

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By Medicover Hospitals / 27 March 2021
Home | Medicine | Modafinil

What is Modafinil?

  • Modafinil, also known as Provigil, is a medication used to treat sleepiness caused by narcolepsy, shift work sleep disorder, or obstructive sleep apnea. While it has been used off-label as a purported cognitive enhancer, the research on its efficacy for this purpose is inconclusive.
    1. Modafinil Uses
    2. Modafinil Side effects
    3. Precautions
    4. Dosage
    5. Storage
    6. Modafinil vs Armodafinil
    7. Frequently Asked Questions
    8. Citations

    Modafinil Uses

  • Modafinil decreases sleepiness caused by narcolepsy and other sleep disorders, such as periods of no breathing while sleeping (obstructive sleep apnea). It is also used to help you stay awake during the workday if your work schedule prevents you from having a regular sleep routine (shift work sleep disorder). This medication does not treat sleep disorders and may not completely eliminate your sleepiness. It is not a substitute for getting enough sleep. It should not be used to treat tiredness or to keep people from sleeping if they do not have a sleep disorder. It's unclear how this works to keep you awake. It is thought to work by influencing certain brain chemicals.
  • How to use Modafinil

  • Before you begin using modafinil, and each time you get a refill, read the Medication Guide provided by your pharmacist. If you have any confusion regarding the dosage, consult your doctor or pharmacist.
  • Take this medication orally with or without food as directed by your doctor for narcolepsy, usually once daily in the morning. Alternatively, if directed by your doctor, the total daily dose of this may be divided into morning and noon dose.
  • Take this medication orally with or without food as directed by your doctor for obstructive sleep apnea, usually once daily in the morning. Continue with other treatments (such as the CPAP machine or mouth device) unless your doctor instructs you to discontinue them.
  • For a sleep disorder, take it orally, with or without food, as directed by your doctor, usually once a day, 1 hour before your work shift begins.
  • The dosage is dependent on your medical condition as well as your response to treatment. To get the advantage of this medication, take it on a regular basis.
  • If you stop taking this medication abruptly, you may experience withdrawal in symptoms (such as shaking, sweating, chills, nausea, vomiting, confusion). To prevent symptoms of withdrawal, your doctor might gradually decrease your dose. Withdrawal is more likely if you have used this medicine for an extended period of time or in high doses.
  • When this medication is used for an extended period of time, it may lose its effectiveness. Consult your doctor if this medication is no longer working properly.
  • Despite the fact that it benefits many people, this medication can sometimes lead to addiction. If you have a substance use disorder (such as overuse or addiction to drugs/alcohol), your risk may be increased.
  • Modafinil Side effects:

    • Headache
    • Dizziness
    • Difficulty falling asleep
    • Drowsiness
    • Nausea
    • Diarrhea
    • Constipation
    • Gas
    • Heartburn
    • Loss of appetite
    • Unusual tastes
    • Dry mouth
    • Excessive thirst
    • Nosebleed
    • Flushing
    • Sweating
    • Tight muscles or difficulty moving
    • Back pain
    • Confusion
    • Burning, tingling, or numbness of the skin

    Precautions

  • Inform your doctor if you are allergic to this medicine or armodafinil, or if you have any other allergies. Inactive ingredients might be in this product that might cause allergic reactions or other problems.
  • Tell your doctor or pharmacist about your medical history, especially if you have: heart problems after taking stimulant drugs like amphetamines (including chest pain and irregular heartbeat), high blood pressure, liver problems, or mental/mood disorders.
  • Sleep problems can impair your ability to react quickly. Even if it helps you stay awake, you may not be able to do things that require quick reactions safely (such as driving). This medication may also cause dizziness. Alcohol can make you feel dizzy.
  • If you are pregnant, notify your doctor. It is not recommended to be taken during pregnancy. This has the potential to harm an unborn child. Inquire about the risks and benefits of this medication right away.
  • It is not known that this drug passes into breast milk or not. Consult before breast-feeding your infant.
  • Interactions

  • Modafinil can accelerate the elimination of other medications from your body, which may have an effect on how they work.
  • Some products contain ingredients that may cause your heart rate or blood pressure to rise. Inform your pharmacist about the medications you're taking and ask how to use them safely (especially cough-and-cold products or diet aids).
  • Overdose

  • If someone has taken an overdose of this medicine and has serious symptoms such as trouble breathing, seek medical advice immediately. Never take more doses than what is prescribed to you by your doctor.
  • Missed Dose

  • It is necessary to take each dose of this medication on time. If you forget a dose, contact your doctor or pharmacist as soon as possible to arrange for a new dosing schedule. Do not double the dose.
  • Storage

  • The medicine should not come in direct contact with heat, air, light and may damage your medicines. The medicine must be kept in a safe place and far away from children’s reach.
  • Modafinil vs Armodafinil

    Modafinil
    Armodafinil
    Modafinil, also known as Provigil, is a medication used to treat sleepiness caused by narcolepsy, shift work sleep disorder, or obstructive sleep apnea. Armodafinil promotes wakefulness
    It decreases excessive sleepiness caused by narcolepsy and other sleep disorders, obstructive sleep apnea. Armodafinil is used for treating problems related with sleep caused by narcolepsy (a condition that causes excessive daytime sleepiness) or shift work sleep disorder
    It may work by increasing the amount of dopamine (a chemical neurotransmitter used by nerves to communicate with one another) in the brain while decreasing dopamine reuptake into nerves. Armodafinil may be considered a stronger drug with better wakefulness effects in some cases.

    Frequently Asked Questions:

    Modafinil decreases sleepiness caused by narcolepsy and other sleep disorders, such as periods of no breathing while sleeping (obstructive sleep apnea). It is also used to help you stay awake during the workday if your work schedule prevents you from having a regular sleep routine (shift work sleep disorder).
    It is best taken once daily at a dose of 200mg. It has been discovered to be well-tolerated, with a low incidence of side effects and a low potential for abuse.
    It starts working within 30 to 60 minutes of taking it. If you take it with food, the drug may take a little longer to kick in.
    Modafinil is a prescription drug that promotes wakefulness and reduces the extreme sleepiness associated with sleep disorders such as narcolepsy, obstructive sleep apnea, and shift work disorder (SWD). It is sometimes used off-label to treat ADHD symptoms in adults 18 and older.
    Modafinil's effective elimination half-life after multiple doses is approximately 15 hours. Modafinil's pharmacokinetic properties are linear and time-independent.
    The exact mechanism of this medicine is unknown, but it affects many neurotransmitter systems in the brain. Some studies suggest that it may improve performance on complex tasks in healthy people; however, no long-term studies have been conducted to determine whether this prevents cognitive decline or dementia.
    In some cases, this medicine has shown a result in weight loss.
    Researchers concluded from a review of 24 studies on the use of this medicine healthy, non-sleep deprived individuals that it is more likely to help improve attention and concentration.
    Antidepressants are frequently ineffective in treating major depression, so it is critical to investigate alternative medicine treatments. Energy loss/fatigue and anxiety are two of the most common symptoms of depression. Modafinil's mechanism of action is novel, and it may have antidepressant properties.

    Citations:

  • Modafinil, https://pubs.acs.org/doi/abs/10.1021/acschemneuro.7b00374
  • Modafinil side effects , https://link.springer.com/article/10.1007/s00213-002-1250-8