Linagliptin Tablet: Benefits, Dosage and Side Effects

Linagliptin is a prescription medication used primarily to manage type 2 diabetes. It helps control blood sugar levels and is often combined with metformin for better results.

Linagliptin belongs to the class of drugs known as dipeptidyl peptidase-4 (DPP-4) inhibitors, which help increase the amount of insulin in the body, thereby lowering blood sugar levels.

What Are the Uses of Linagliptin Tablet?

This medicine plays a key role in blood sugar regulation, especially for people with type 2 diabetes.

Conditions used to treat

• Manages Type 2 Diabetes: It is used alongside diet and other medications to help control blood sugar levels in patients with type 2 diabetes.
• Enhances Insulin Secretion: It stimulates the body to release more insulin when needed.
• Combines Well with Other Medications: It can also be used in combination with insulin to treat diabetes.

How Does Linagliptin Work?

Linagliptin helps regulate blood sugar by boosting your body's natural insulin response.

• Belongs to a class of drugs called DPP-4 inhibitors.
• Increases the release of incretin hormones, which raise insulin and lower glucagon.
• Helps reduce blood sugar only when it's high, reducing the risk of hypoglycemia.

Dosage of Linagliptin

Follow your doctor's instructions exactly to avoid side effects and ensure effective treatment.

• Available Brands in India: Jentadueto (combination of linagliptin + metformin)

Immediate-Release Oral Tablet:

• Linagliptin 2.5 mg/metformin 500 mg
• Linagliptin 2.5 mg/metformin 850 mg
• Linagliptin 2.5 mg/metformin 1, 000 mg

Extended-Release Oral Tablet:

• Linagliptin 2.5 mg/metformin 1, 000 mg
• Linagliptin 5 mg/metformin 1, 000 mg

For Type 2 Diabetes:

• Adult dosage: 2.5 mg of linagliptin and 500 mg of metformin
• Maximum dosage: 5 mg of linagliptin and 2000 mg of metformin per day

How to Take Linagliptin

• Form: Linagliptin comes in tablet form.
• Dosage: Take once daily with or without food at the same time each day.
• Adherence: Follow the directions on the prescription label and ask your doctor if you have any questions.

What Should I Do If I Miss a Dose of Linagliptin?

Missing a dose occasionally happens, but it's important to take action carefully.

• Take as soon as remembered unless it is close to the next dose.
• Do not double the dose to catch up.

What Happens If I Overdose on Linagliptin?

Overdosing can lead to harmful effects on your body. Seek medical assistance immediately in case of an overdose.

• Symptoms like weakness, confusion, or a fast heart rate.

What Are the Side Effects of Linagliptin?

Like all medicines, linagliptin may cause side effects, although not everyone gets them.

Common Side Effects

• Diarrhea
• Loss of appetite
• Nausea
• Vomiting
• Skin itching

Serious Side Effects

• Lactic Acidosis: Symptoms include weakness, muscle pain, breathlessness, stomach pain, diarrhea, and irregular heartbeat.
• Low Blood Sugar (Hypoglycemia): Symptoms include sweating, fast heart rate, and dizziness.
• Allergic Reactions: Symptoms include swelling of the face, trouble swallowing, and skin rash.

If you notice any unusual or severe symptoms, contact your doctor immediately.

Precautions for Linagliptin

It's important to discuss your health history and any ongoing conditions with your doctor.

• Allergies: Inform your doctor if you are allergic to Linagliptin or any other medications.
• Medical History: Discuss any medical conditions such as pancreatic disease, gallbladder stones, or heart failure.

Warnings for Serious Health Conditions

• Kidney Disease: Severe kidney disease increases the risk of lactic acidosis and heart failure.
• Liver Problems: Your doctor will monitor your liver function before and during treatment.
• Low Levels of Vitamin B12: Linagliptin can reduce blood levels of vitamin B12.
• Pancreatitis: Linagliptin can cause or worsen pancreatitis.

Are There Any Age Restrictions for Using Linagliptin?

This medicine is typically prescribed for adults with type 2 diabetes. It is not recommended for children unless advised by a doctor.

Can I Take Linagliptin with Alcohol or Certain Foods?

Combining this medicine with alcohol may increase the risk of lactic acidosis or low blood sugar.

• Avoid excessive alcohol consumption.
• Stick to a balanced diabetic diet for best results.

Possible Drug Interactions with Linagliptin

Make sure your doctor knows about all medicines or supplements you take.

• May interact with insulin or sulfonylureas, increasing the risk of hypoglycemia.
• Be cautious with diuretics, heart medications, or herbal products.

How Should Linagliptin Be Stored?

Proper storage ensures the medicine remains effective and safe to use.

• Store at room temperature (68ºF to 77ºF or 20ºC to 25ºC).
• Keep away from heat, air, light, and out of reach of children.

Linagliptin Vs Sitagliptin

Consult your doctor before starting Linagliptin and for any side effects or reactions you experience. Carry your medication while traveling and follow your doctor's advice closely for the best results in managing your diabetes.

References