Lactulose oral solution is a prescription drug which is available as the brand name drug called Duphalac, Enulose and Generlac. This is also available as a generic drug.
Lactulose is a synthetic disaccharide, a form of sugar that is broken down into mild acids in the large intestine that draws water into the colon, helping to soften the stools.
The lactulose solution is used to treat chronic constipation. Lactulose solution is sometimes used to treat or avoid liver disease complications.
Lactulose Solution Uses
Lactulose is used orally or rectally to manage complications of liver disease, specifically hepatic encephalopathy.
It helps improve mental function by reducing ammonia levels in the blood.
Lactulose functions as a colonic acidifier, lowering ammonia absorption by increasing colon acidity.
Derived from synthetic sugars, it is available as an oral solution primarily for treating constipation. Additionally, it is used in the management of portal-systemic encephalopathy, Lactose Intolerance, a brain condition linked to severe liver disease.
What is it commonly used for?
Chronic constipation
Hepatic encephalopathy (a liver-related brain disorder)
Quick Highlight of Its Benefits or Effectiveness
Effective in softening stool and promoting bowel movements
Reduces toxic ammonia levels in patients with liver disease
Generally safe and well-tolerated for long-term use
Conditions Lactulose is Used to Treat
Constipation, especially chronic or opioid-induced
Hepatic encephalopathy - by reducing ammonia absorption in the intestine
How does the Lactulose Solution work?
Lactulose belongs to a drug class known as laxatives. A community of medicines that function in a similar way is a class of drugs. For the treatment of related conditions, these medications are also used. Lactulose is a (man-made) synthetic sugar. In the large intestine, it breaks down and then pulls water into the intestine. This softens the stool, helping to alleviate constipation.
Lactulose is also used in the treatment of elevated blood levels of ammonia due to liver disease. Portal-systemic encephalopathy may result from high levels of ammonia. By extracting ammonia from your blood into your large intestine, this medication works. Then, through your stool, the large intestine extracts the ammonia. To understand how Lactulose works and its suitability for your condition, consult our Gastroenterologists for expert advice.
Dosage of Lactulose Solution
Dosage for Constipation
Typical dosage: 1-2 tablespoons once per day
Dosage for Portal-systemic encephalopathy (Liver Disease)
Typical dosage: 2-3 tablespoons for three to four times a day
Forms and Strengths
Brand: Generlac
Form: oral solution
Strengths: 10 g/15 mL
Generic: Lactulose
Form: oral solution
Strengths: 10 g/15 mL
Brand: Enulose
Form: oral solution
Strengths: 10 g/15 mL
What Should I Do If I Miss a Dose?
Don't worry, if you forget a dose of lactulose, just take the next dose at the normal time. Avoid taking 2 doses at the same timing. If you miss a dose, don't take any extra dose for it.
If your doctor has told you to take lactulose on a regular basis and you sometimes forget your doses, setting an alarm to remind you of this can help. You can also ask for advice from your pharmacist on other ways to help you remember to take your medication.
What happens if an Overdose?
Taking an extra dose of lactulose is unlikely to hurt you. You may get indigestion and stomach pain, but within a day or two, this should ease away. Speak to your doctor or pharmacist for guidance if you're concerned.
Symptoms of Lactulose Solution Overdose
An overdose of Lactulose Solution is usually not life-threatening but may cause uncomfortable gastrointestinal symptoms. These may include:
Severe diarrhea
Bloating or gas
Abdominal cramps or pain
Dehydration (due to fluid loss from diarrhea)
Electrolyte imbalance (like low sodium or potassium)
Nausea and vomiting
Consult your healthcare provider before taking medication. Immediate medical attention is required if an overdose is suspected.
Get a second opinion from trusted experts and makeconfident, informed decisions.
If any serious side effects occur, visit our Hospital Department for prompt evaluation and treatment.
Precautions and Warnings of Lactulose Solution
Before using Lactulose Solution talk with your doctor if you are having any allergies or some other medications. The product may contain some inactive ingredients which can cause some serious problems or some other serious problems.
Lactulose should not be used if you have certain medical conditions, including:
Low Galactose Diet: Since lactulose is a type of sugar, it may not be suitable for those on a galactose-restricted diet.
Bowel Obstruction: If you have any form of bowel obstruction, lactulose could worsen the condition.
Diabetes: People with diabetes should use lactulose with caution, as it can affect blood sugar levels.
Who Should Avoid Lactulose?
Lactulose should be avoided by the following individuals:
Those with Bowel Obstruction: If you have a blockage in your intestines, lactulose can worsen the condition.
People on a Low Galactose Diet: Since lactulose is a sugar, it is not recommended for individuals who need to limit galactose intake.
Individuals with Severe Diabetes: Lactulose can affect blood sugar levels, so people with severe diabetes should avoid it unless prescribed by a doctor.
Allergic Reactions: If you are allergic to lactulose or any of its ingredients, you should avoid using it.
Those with Severe Liver Disease: Lactulose should be used cautiously in individuals with liver problems, as it can affect the body's ability to handle the medication.
If you experience persistent diarrhea, abdominal pain, or any allergic reaction, book an appointment with our Gastroenterology Department for a detailed assessment.
Are There Any Age Restrictions for Using Lactulose?
Can be used in infants, children, and elderly under medical supervision
Doses must be adjusted by a doctor
Alcohol or Food Interactions
Alcohol:
No known direct interactions, but avoid in hepatic encephalopathy patients
Food:
Can be taken with or without food
May be mixed with juice or water to improve taste
How to take Lactulose Solution?
Typically, if you take this medicine orally for liver disease, take it 3-4 times a day or as instructed by your doctor.
You may blend it into fruit juice, wine, milk, or a soft dessert to enhance the flavour.
Per day, the objective is to have 2-3 soft stools.
The dose depends on the medical condition and your reaction to treatment (i.e., the number of soft stools each day).
If you are taking this drug by mouth for constipation, you can generally take it once a day or as recommended by your doctor. It is also possible to administer this drug rectally as an enema for liver disease. Mix 700 milliliters (24 ounces) of water or regular saline into the prescribed amount of lactulose.
Possible Interactions with Other Medications (Drug Interactions)
May Interact With:
Antacids - may reduce effectiveness
Other laxatives - combined use may cause excessive diarrhea
Caution with potassium supplements or herbal laxatives - risk of electrolyte disturbance
Always inform your healthcare provider about all products you're using.
Storage of Lactulose Solution
The medication can get damaged by direct contact with sun, air and light. Any adverse effects can be caused by exposure to the medication. It is best to keep the medication in a safe place and out of the reach of children. The medication'should primarily be maintained at a room temperature of between 68ºF and 77ºF (20ºC and 25ºC).
What Happens If Lactulose Is Not Stored Properly?
May become less effective
Changes in taste or texture may occur
Do not use if the solution turns dark brown or shows signs of contamination
Lactulose Solution vs Cremaffin
Lactulose Solution
Cremaffin
Lactulose oral solution is a prescription drug which is available as the brand name drug called Enulose and Generlac. This is also available as a generic drug.
Cremaffin Syrup is a laxative which is used to alleviate constipation.
Lactulose is an oral solution for the treatment of constipation. It is also used to treat portal-systemic encephalopathy, a brain problem. A complication of serious liver disease is this problem
It is used to provide constipation with gentle and efficient relief. It softens the stool, making it easier to move through.
Some of the common side effects of Lactulose Solution are:
Yes, lactulose oral solution is effective for constipation by increasing water content and stimulating bowel movements, providing relief from irregular bowel movements.
Duphalac syrup, containing lactulose, is primarily used to treat constipation by softening stools and increasing bowel movement frequency.
Lactulose is also used in patients with liver disease to decrease the amount of ammonia in their blood. By extracting ammonia from the blood into the colon where it is extracted from the body, it works.
Before consulting with your doctor, do not start, stop, or adjust the dosage of any medication. Lactulose has no known interactions with other medicines that are significant.
Yes, lactulose is generally considered safe during pregnancy, but it should only be used under a doctor’s supervision to treat constipation.
Yes, lactulose is safe for children when prescribed by a pediatrician. Dosage should be adjusted based on the child’s age and condition.
Yes, you can mix lactulose with juice or water to improve its taste. This does not reduce its effectiveness.
Both are laxatives, but lactulose is a synthetic sugar, while sorbitol is naturally occurring. Lactulose is often preferred for chronic constipation and liver conditions.
Disclaimer: The information provided is accurate and up-to-date to the best of our knowledge. However, it should not be considered a substitute for medical advice or consultation. We do not guarantee its completeness or accuracy. The absence of specific warnings does not mean a medicine is safe for all users. We are not responsible for any outcomes based on this information and strongly recommend consulting a doctor for any medical concerns or questions.
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