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Doripenem

Doripenem

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By Medicover Hospitals / 06 April 2021
Home | Medicine | Doripenem

Doripenem

  • Doripenem is a prescription antibiotic that treats severe bacterial infections related to kidneys, urinary tract, and stomach. It belongs to the class of medicines known as carbapenems. These function by interacting with bacteria's ability to form a cell wall.
    1. Doripenem Uses
    2. Doripenem Side effects
    3. Precautions
    4. Dosage
    5. Warnings
    6. Storage
    7. Doripenem vs Imipenem
    8. Frequently Asked Questions
    9. Citations

    Doripenem Uses:

  • Doripenem injection is used to treat severe bacterial infections of the urinary tract, kidneys, and abdomen. The Food and Drug Administration (FDA) has not approved doripenem injection for treating pneumonia in people who were on a ventilator in a hospital. These antibiotics don’t work for any viral infections like colds and flu. Taking antibiotics when it is not needed may increase the risk of getting an infection that resists antibiotic treatment.
  • Side Effects:

  • Some of the common & major side effects of Doripenem are:
    • Vomiting
    • Headache
    • Nausea
    • Diarrhea
    • Redness or pain in the injection site
    • Hives
    • Itching
    • Rash
    • Blisters of the skin
    • Sloughing of the skin
    • Fever
    • Difficulty while breathing
    • Seizures
    • Excessive tiredness
    • Weakness
    • Shortness of breath
    • Pale skin
  • While a person is under the treatment of this drug they might experience certain side effects that may not be adverse. But if your reactions persist or worsen over time then contact your doctor immediately.
  • Precautions:

  • Talk with your doctor if you are allergic to Doripenem or any other medications related to it. The product may contain some inactive ingredients which can cause some serious allergic reactions or some other serious problems. Before using the medications talk to your doctor if you are having any other medical history such as Kidney disease, seizures and stroke. The drug can cause live bacterial vaccination not to work properly. Avoid taking any immunization or vaccination while you are using any medication unless your doctor advises you to. Kidney function may decline as you grow older. So the older adults are at greater risk and can get adverse effects while you are using this drug.
  • How to use Doripenem?

  • Doripenem injection is administered intravenously as a liquid (into a vein). It's usually issued every eight hours. The length of your treatment will be determined by the type of infection you have. After your condition has improved, your doctor may change the medication to a different antibiotic that can be taken orally. You can get a doripenem injection in a hospital. If you're using injection at home, make sure to take it at the same time each day.
  • Dosage

  • For the treatment of Intraabdominal infection, Pyelonephritis and urinary tract infections
  • 500 mg IV infusion in every 8 hours
  • Duration therapy: 5 to 14 days
  • Missed Dose

  • As soon as you remember, take the missing dose. If it’s time for the next dose, skip the missed dose and return to the daily dosing schedule. To make up for a missed dose, do not take a double dose as it can result in some serious adverse effects
  • Overdose

  • You may experience symptoms such as stomach ache, nausea, and vomiting if you accidentally took too much of this medication. If you have taken an overdose of the drug, contact your doctor right away or go to the nearest hospital.
  • Warnings for serious Health Conditions:

  • Pregnancy & Breastfeeding:
  • Doripenem is classified as a pregnancy category C drug. However, when no other options are available, the advantage of using it could outweigh the risk of not treating a serious infection in a pregnant woman. Consult with your doctor before taking any kind of medications during pregnancy.
  • There is no evidence of doripenem while breastfeeding. Its excretion into breast milk is likely to be close to that of imipenem and meropenem, which contain low levels in milk and are unlikely to affect breastfed babies. So before taking any kind of medications talk to your doctor while breastfeeding.
  • Storage:

  • Direct contact with heat, air and light may damage your medicines. Exposure to medicine may cause some harmful effects. The medicine must be kept in a safe place and out of children’s reach.
  • Mainly the drug should be kept at room temperature between 68ºF and 77ºF (20ºC and 25ºC).
  • Doripenem vs Imipenem

    Doripenem
    Imipenem
    Doripenem is a prescription antibiotic that treats severe bacterial infections related to kidneys, urinary tract, and stomach. It belongs to the class of medicines known as carbapenems. Imipenem is a semisynthetic thienamycin that has antibacterial activity against both gram-positive and gram-negative aerobic and anaerobic bacteria, as well as a number of multiresistant strains.
    The injection is used to treat severe bacterial infections of the urinary tract, kidneys, and abdomen. The injections are used to treat Endocarditis and respiratory tract (including pneumonia), urinary tract and abdominal disorder.
    Some of the common & major side effects of Doripenem are:
    • Vomiting
    • Headache
    • Nausea
    • Diarrhea
    Some of the common side effects of Imipenem are:
    • Nausea
    • Vomiting
    • Headache
    • Diarrhea
    • Redness

    Frequently Asked Questions:

    The medication is a prescription antibiotic that treats severe bacterial infections related to kidneys, urinary tract, and stomach. It belongs to the class of medicines known as carbapenems. These function by interacting with bacteria's ability to form a cell wall.
    Some of the common & major side effects of Doripenem are:
    • Vomiting
    • Headache
    • Nausea
    • Diarrhea
    Doripenem injection is administered intravenously as a liquid (into a vein). It's usually issued every eight hours. The length of your treatment will be determined by the type of infection you have.
    Before using the medications talk to your doctor if you are having any other medical history such as Kidney disease, seizures and stroke. The drug can cause live bacterial vaccination not to work properly.

    Citations:

  • Doripenem, https://academic.oup.com/cid/article/49/2/291/406997?login=true
  • Comparative activity of doripenem, https://www.sciencedirect.com/science/article/abs/pii/S0732889305000040