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Diosmin

diosmin

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By Medicover Hospitals / 23 Feb 2021
Home | Medicine | Diosmin

What is Diosmin?

  • Diosmin is a type of chemical from plants found primarily in citrus fruits. Diosmin is used by people to make medicine. Diosmin is used to treat different blood vessel disorders, including hemorrhoids, varicose veins, impaired leg circulation (venous stasis), and eye or gum bleeding (hemorrhage). It is also used to treat swelling of the arms (lymphedema) and to protect against liver toxicity after breast cancer surgery. It is also taken with hesperidin, another chemical from a plant, in combination.
    1. Diosmin Uses
    2. Diosmin Side effects
    3. Precautions
    4. Diosmin vs Daflon
    5. Frequently Asked Questions
    6. Citations

    Diosmin Uses:

    • Hemorrhoids - Taking diosmin at high doses along with hesperidin appears to reduce the symptoms of hemorrhoids. It also appears that taking diosmin at lower doses along with hesperidin plus troxerutin is helpful. Taking diosmin at lower doses along with hesperidin appears to help prevent hemorrhoids from returning.
    • Leg pain caused by the weak circulation of blood (venous leg ulcer) - Taking diosmin with hesperidin and using compression dressing seems to help heal leg ulcers caused by poor circulation.
    • Back pain - Early research suggests that taking diosmin for at least 8 weeks reduces pain and, similar to getting the regular drugs mannitol and dexamethasone, could decrease the need to use rescue pain medication.
    • Poor circulation, which can swell the legs (chronic venous insufficiency or CVI). Some research shows that diosmin can help to reduce pain in individuals with CVI by a small amount.
    • Swelling in the arms or legs as a result of lymphatic system injury (lymphedema). Diosmin with hesperidin does not minimize swelling of the arms following breast cancer surgery.
    • Chronic venous disease - refers to disorders affecting the legs' veins. Chronic venous insufficiency, for example, is a condition in which the veins do not adequately return blood to the heart from the legs, and is associated with varicose veins, swelling of the foot, and cramping of the leg at night. According to reports, diosmin and hesperidin may help to treat chronic venous disease. Decreases in leg fluid volume were more common after treatment with micronized diosmin and hesperidin (or other medications or placebo) in those taking diosmin and hesperidin.

    How does it work?

  • By reducing swelling (inflammation) and restoring normal vein function, Diosmin might work. It also seems that Diosmin has antioxidant properties.
  • Diosmin Side effects:

    • Stomach pain
    • Diarrhea
    • Dizziness
    • Lightheadedness
    • Weakness
    • Tiredness
    • Drowsiness
    • Abdominal pain
    • Headache
    • Skin redness
    • Rashes
    • Hives
    • Muscle pain
    • Blood problems
    • Altered heart rate
    • Fast heartbeat

    Precautions:

  • Pregnancy and breast-feeding - Diosmin use during pregnancy and breast-feeding is not sufficiently understood. Stay on the safe side to prevent being seen.
  • Bleeding disorders - Diosmin may exacerbate bleeding disorders. Don't use diosmin if you have a bleeding condition.
  • Dosage and administration:

  • Diosmin is also taken with hesperidin in combination. Scientific research suggests the following doses:
  • Orally: For internal hemorrhoid treatment: 1350 mg of diosmin plus 150 mg of hesperidin twice daily for 4 days, 900 mg of diosmin, and 100 mg of hesperidin twice daily for 3 days, respectively. Some researchers also try diosmin 600 mg three times a day for 4 days, followed by diosmin 300 mg twice a day for 10 days, in combination with psyllium 11 grams a day. Nevertheless, this lower dose of diosmin does not seem to be as successful.
  • For the prevention of recurrence of internal hemorrhoids: diosmin 450 mg plus hesperidin 50 mg twice daily for 3 months of treatment.
  • The combination of 900 mg of diosmin and 100 mg of hesperidin daily has been used for up to 2 months in the treatment of leg wounds due to blood flow issues (venous stasis ulcers).
  • Diosmin vs Daflon:

    Diosmin
    Daflon
    Diosmin is a type of chemical from plants found primarily in citrus fruits. Diosmin is used by people to make medicine. In the treatment of acute or chronic hemorrhoids, varicose veins, and lymphedema, the Daflon 500mg Tablet is used. In the veins, it stimulates blood flow and restores its function.
    Uses -Hemorrhoids, Leg pains Uses -Varicose veins, Piles, Lymphedema
    Diosmin is safe for most people when used short-term for up to three months. Side effects - Abdominal pain, Diarrhea,Headache,Nausea
    By reducing swelling (inflammation) and restoring normal vein function, Diosmin might work. It also seems that Diosmin has antioxidant properties. The 500mg Daflon Tablet is a flavonoid. It works by blocking the action of chemical messengers which cause vein inflammation (swelling) (prostaglandins, thromboxane A2). This increases blood flow in the veins and restores the proper functioning of the veins.

    Frequently Asked Questions:

    Diosmin is used to treat different blood vessel disorders, including hemorrhoids, varicose veins, impaired leg circulation (venous stasis), and eye or gum bleeding (hemorrhage). It is also used to treat swelling of the arms (lymphedema) and to protect against liver toxicity after breast cancer surgery.
    Diosmin is not a recommended daily allowance. In particular conditions, the following doses have been studied: Chronic Venous Disease: 900 mg of diosmin plus 100 mg of hesperidin per day for up to 2 months.
    The protective function of diosmin has also been verified by histopathology of the heart and kidney. The experiment has therefore clearly demonstrated that diosmin acts as an antihypertensive agent against hypertension caused by DOC-salt.
    Diosmin is a natural flavonoid found primarily in some citrus fruit peels, such as oranges and lemons.
    Hesperidin is most widely used for blood vessel disorders such as hemorrhoids, varicose veins, and impaired circulation, either alone or in conjunction with other citrus bioflavonoids (such as diosmin) (venous stasis).
    When used for short-term use for up to three months, Diosmin is safe for most individuals. Any side effects can be caused by it, such as stomach and abdominal pain, diarrhea, and headache. Do not take Diosmin for more than three months without medical supervision.
    Vitamin C is known to prevent cell damage due to its antioxidant properties. These properties facilitate the development of collagen as well as reinforce blood vessels. These two factors help avoid the deterioration of varicose veins. Citrus fruits, peppers, onions, spinach, broccoli, and more can contain vitamin C.
    By reducing swelling (inflammation) and restoring normal vein function, Diosmin might work. It also seems that Diosmin has antioxidant properties.
    Diosmin can make bleeding in individuals with bleeding disorders worse. If you have any bleeding problems, stop this supplement unless your healthcare provider directs you otherwise ( 30, 31 ). Diosmin should be avoided by children and adolescents since there is no available safety data in these age groups.
    The procedure was widely known and did not impact pregnancy, development of the fetus, birth weight, growth of infants, and feeding. In the short term, 90 percent micronized diosmin and 10 percent hesperidin are safe, appropriate, and effective in the treatment of pregnancy hemorrhoids.
    When taken by mouth in the short term, Diosmin is Probably SAFE for most people. Some side effects can be induced, such as stomach pain, diarrhea, dizziness, fever, redness of the skin and rashes, pain in the muscles, blood problems, and heart rate changes.

    Citations:

  • Diosmin, https://cancerres.aacrjournals.org/content/58/13/2754.short
  • Diosmin side effects , https://www.sciencedirect.com/science/article/abs/pii/S0753332210000326