Diosmin is a plant-derived compound commonly found in citrus fruits such as oranges and lemons. It is widely used as a dietary supplement to support blood vessel and circulatory health. Diosmin is often combined with another natural flavonoid, hesperidin, for enhanced therapeutic effect.
What is Diosmin?
Diosmin is a natural flavonoid glycoside belonging to the flavone class of compounds, with the molecular formula C28H32O15. It is known for its vasoprotective properties and is used to manage conditions like chronic venous insufficiency, varicose veins, and hemorrhoids. Available mainly in tablet or capsule form, it works by improving vein tone, reducing inflammation, and enhancing lymphatic drainage.
What Are the Uses of Diosmin?
Diosmin is primarily used to improve blood circulation and strengthen blood vessel walls, which helps alleviate symptoms associated with various venous disorders.
Conditions Diosmin Treats
Diosmin is used to treat a range of conditions, including:
Beyond its primary uses, Diosmin is also utilized to treat swelling of the arms (lymphedema) and to offer protection against liver toxicity, particularly after breast cancer surgery.
How Does Diosmin Work (Mechanism of action)?
Diosmin primarily functions by enhancing the tone and strength of blood vessels, especially veins, and by improving overall blood circulation. Additionally, it acts as an antioxidant, contributing to its therapeutic effects.
Diosmin Dosage
Diosmin dosage varies depending on the condition being treated, and it is crucial to follow a doctor's advice for proper administration.
Typical Dosage Instructions (as per doctor's advice)
Internal Hemorrhoid Treatment:1350 mg of diosmin plus 150 mg of hesperidin twice daily for four days. Alternatively, 900 mg of diosmin and 100 mg of hesperidin twice daily for three days. Another regimen involves taking diosmin 600 mg three times a day for four days, followed by Diosmin 300 mg twice daily for ten days, along with psyllium 11 grams a day.
Prevention of Recurrence of Internal Hemorrhoids:450 mg of diosmin plus 50 mg of hesperidin twice daily for three months.
Treatment of Leg Wounds due to Blood Flow Issues (Venous Stasis Ulcers):A combination of 900 mg of diosmin and 100 mg of hesperidin daily for up to two months.
Chronic Venous Disease: 1, 000 mg per day for 3-6 months.
Varicose Veins: 1, 000-2, 000 mg per day for up to 6 months.
Diosmin for Hemorrhoids - Dosage
For acute hemorrhoid attacks, the typical dosage is:
First 4 days: 6 tablets per day (3 in the morning, 3 in the evening)
Next 3 days: 4 tablets per day (2 in the morning, 2 in the evening)
Each tablet usually contains Diosmin 450 mg + Hesperidin 50 mg. Always follow your doctor's instructions for exact dosage.
What Should I Do If I Miss a Dose of Diosmin?
If you miss a dose of Diosmin, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
What happens if an Overdose?
While there are no known cases of diosmin overdose or reports of toxicity to date, an overdose might lead to increased gastrointestinal discomfort, headache, or general malaise. If you suspect an overdose or experience severe symptoms, it is crucial to stop taking the medication and consult your doctor immediately.
Symptoms of overdose
Symptoms of a potential overdose may include severe gastrointestinal upset, headache, and unusual bleeding.
What to avoid
Avoid taking more than the recommended dose unless instructed to do so by your healthcare provider. If you experience severe pain, severe diarrhea (10 or more loose stools in 24 hours), or an irregular heartbeat, seek medical attention immediately.
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In rare but severe cases, Diosmin can cause blood disorders, irregular heartbeats, or a rapid heartbeat.
Advise users to consult a doctor if any symptoms worsen
If you experience any side effects after taking diosmin, discontinue use and speak with your healthcare provider. If you experience severe pain, severe diarrhea (10 or more loose stools in 24 hours), or an irregular heartbeat, seek medical attention immediately.
Precautions and Warnings
Certain precautions and warnings should be considered before taking Diosmin to ensure its safe and effective use.
Who should avoid this medicine?
Diosmin is not recommended for individuals with known hypersensitivity to the flavonoid itself. Those with severe bleeding disorders should also avoid it, as it may worsen the condition.
Conditions where caution is needed
Caution is needed if you have any bleeding disorders, as diosmin may worsen them.
Are There Any Age Restrictions for Using Diosmin?
Diosmin is generally intended for adult use and is not typically recommended for children or teenagers due to a lack of safety research in these age groups. Specific age restrictions are usually set to exclude pediatric use unless a doctor advises explicitly.
Alcohol or food interactions
Alcohol consumption is generally discouraged while taking Diosmin, as it may increase the risk of liver damage. Diosmin may interact with certain herbal supplements, such as garlic, fenugreek, ginger, ginkgo, ginseng, and turmeric.
Possible Interactions with Other Medications (Drug Interactions)
Diosmin can interact with various medications, potentially affecting their efficacy or increasing the risk of side effects.
Overview of how this medicine may interact with other drugs
Diosmin may interact with:
Anticoagulants, Such as warfarin and heparin, increase the chances of bruising and bleeding.
Antiplatelet agents, such as clopidogrel and aspirin, also increase bleeding risk.
Antihypertensive medications: Such as lisinopril, atenolol, and amlodipine.
NSAIDs: Including ibuprofen and naproxen.
Hormonal Contraceptives: Diosmin can reduce the effectiveness of birth control pills.
Certain cancer drugs, Such as doxorubicin and vincristine.
Immunosuppressants: Like sirolimus.
Heart medications, Such as digoxin.
Colchicine: Used for gout.
Medications transported by cell pumps: Diosmin may reduce the activity of these pumps, increasing the absorption of certain drugs and potentially leading to more side effects.
Medications are changed by the liver (Cytochrome P450 3A4 (CYP3A4) substrates).
Diosmin + Hesperidin: Contraindications
While Diosmin and Hesperidin are generally well-tolerated, their use may be contraindicated or cautioned in the following cases:
Condition
Explanation
Allergy or hypersensitivity
Contraindicated in individuals allergic to Diosmin, Hesperidin, or citrus fruits.
Pregnancy and breastfeeding
Not enough well-controlled studies; use only if clearly needed and under supervision.
Severe liver or kidney disease
Caution is advised as metabolism and clearance may be affected.
Children
Safety and effectiveness in children have not been established.
Possible impact when combined with supplements, herbal products
Diosmin may interact with certain herbal supplements known for their blood-thinning properties, including fenugreek, feverfew, garlic, ginger, ginkgo, ginseng, and turmeric. Always inform your doctor about all medications, supplements, and herbal products you are taking.
How Should Diosmin Be Stored?
Proper storage of Diosmin is essential to maintain its effectiveness and ensure its safety.
Diosmin should be stored in a cool, dry place, away from direct sunlight and moisture. Always keep it out of reach of children.
Recommended Storage Temperature for Diosmin
It is recommended to store Diosmin in a cool, dry environment, such as a medicine cabinet. Some sources suggest a recommended storage temperature between 2-8 °C (35-46 °F) for the powder form.
What Happens If Diosmin Is Not Stored Properly?
Improper storage, such as exposure to direct sunlight, heat, or moisture, can degrade the medication and reduce its effectiveness. Always read the label and avoid taking any supplements past their expiration date.
Keep away from children, sunlight, or moisture.
Always keep this medication away from children. Store it in a cool and dry place, away from direct sunlight.
Diosmin vs Daflon
Diosmin
Daflon
Diosmin is a type of chemical from plants found primarily in citrus fruits. It is used in making medicines.
Daflon 500mg Tablet is used for treating acute or chronic hemorrhoids, varicose veins, and lymphedema by stimulating blood flow in the veins and restoring their function.
Uses: Hemorrhoids, Leg pains
Uses: Varicose veins, Piles, Lymphedema
Diosmin is generally safe for most people when used short-term (up to 3 months).
Side effects: Abdominal pain, Diarrhea, Headache, Nausea
Diosmin may reduce swelling (inflammation), restore vein function, and act as an antioxidant.
Daflon is a flavonoid that works by blocking chemical messengers (like prostaglandins, thromboxane A2) that cause vein inflammation, thus improving blood flow.
This combination is commonly used to treat chronic venous insufficiency, varicose veins, and hemorrhoids. It works by improving vein tone, reducing inflammation, and enhancing blood flow in the affected areas.
Yes, Diosmin is generally safe for daily use in recommended doses (typically 500-1000 mg). Consult a doctor for long-term use or specific conditions.
Diosmin may slightly lower blood pressure by improving vascular health, but it’s not primarily used for this purpose. Evidence is limited.
Diosmin is found in citrus fruits like oranges, lemons, and grapefruits, particularly in the peel and membranes. It’s often taken as a supplement.
Hesperidin and Diosmin improve vein health, reduce swelling, and treat conditions like varicose veins, hemorrhoids, and chronic venous insufficiency.
Diosmin can be taken for several months (3-6 months) as prescribed. Consult a doctor for extended use to ensure safety.
People with allergies to Diosmin, bleeding disorders, or on blood thinners should avoid it. Always consult a doctor first.
Diosmin is generally considered safe during pregnancy for short-term use, especially for hemorrhoids, but consult a doctor before taking.
Common side effects include mild stomach upset, headache, or diarrhea. Serious side effects are rare but seek medical advice if severe.
Vitamin C helps prevent varicose veins by supporting collagen development and strengthening blood vessels. Foods rich in vitamin C include citrus fruits, peppers, onions, spinach, and broccoli.
Disclaimer: The information provided is accurate and up-to-date to the best of our knowledge. However, it should not be considered a substitute for medical advice or consultation. We do not guarantee its completeness or accuracy. The absence of specific warnings does not mean a medicine is safe for all users. We are not responsible for any outcomes based on this information and strongly recommend consulting a doctor for any medical concerns or questions.
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