Analgin, also known as metamizole, is a painkiller and fever reducer used to treat various types of Pain, Fever, and Inflammation. Analgin is available in various forms, including Analgin tablet and Analgin injection, offering flexibility in managing different levels. The dosage and duration should be as prescribed by your doctor, preferably taken with food or milk to prevent stomach disturbances. Inform your doctor if you have a history of heart disease or stroke.

What are and Uses of Analgin?

Analgin tablet is a powerful painkiller and fever-reducing medicine. It is often used when other medications don't work. It helps quickly relieve moderate to severe pain and reduce high fever. Analgin injection uses include treatment of severe pain, post-operative pain, and high fever unresponsive to oral medications, especially in emergency settings.

Conditions Analgin Treats

  • Severe headaches or migraines
  • Nerve pain, sore throat, and menstrual pain
  • Tooth pain
  • Post-surgical pain
  • A fever that doesn't respond to other medicines
  • Pain from injuries or trauma
  • Cancer-related pain
  • Asthma, lung infections, severe allergies, or hypertension

Secondary Benefits of Analgin

  • Used in combination with other drugs during surgeries
  • Can be part of emergency treatment for high fever
  • Sometimes used for muscle spasms or menstrual pain
  • Occasionally used for pain due to kidney or gallstones

How Does Analgin Work?

Analgin (metamizole) works mainly by blocking the production of prostaglandins, which are chemicals in the body that cause pain, fever, and inflammation.

Mechanism of Action

  • Blocks Prostaglandins: Analgin inhibits the cyclooxygenase (COX) enzymes that help produce prostaglandins. When prostaglandin levels drop, pain and fever go down.
  • Affects the Nervous System: Analgin may also interact with the brain and spinal cord to reduce how the body senses pain, giving it a central (brain-related) pain-relieving effect.
  • No Direct Hormonal Interaction: Analgin doesn't directly interact with hormones like steroids or insulin. Its action is more focused on pain pathways and fever regulation.
  • Smooth Muscle Relaxation (Minor): In some cases, Analgin may help reduce pain by slightly relaxing smooth muscles, such as those in the stomach or uterus.

Analgin Dosage

Administer orally after a meal, 2-3 times daily at 250-500 mg per dose. The maximum single dose is 1 g, and the daily dose should not exceed 3 g. For infants, a single dose of 5-10 mg/kg is recommended. Dosage for children: 50-100 mg for 2-3 years, 100-200 mg for 4-5 years, 200 mg for 6-7 years, and 250-300 mg 2-3 times daily for 8-14 years.

For emergency cases or patients unable to take oral medications, Analgin injection dosage for adults typically ranges from 500 mg to 1 g, administered slowly intravenously or intramuscularly, up to 2-3 times a day, as directed by a healthcare provider.

What happens if an Overdose of Analgin?

Possible adverse effects include acute agranulocytosis, hemorrhagic syndrome, acute renal and hepatic insufficiency. Signs of toxicity may include.

  • Hypothermia
  • Hypotension
  • Palpitations
  • Breathlessness
  • Tinnitus
  • Nausea
  • Vomiting
  • Fatigue
  • Drowsiness
  • Delirium
  • Decreased consciousness, and
  • Convulsions

Treatment involves inducing vomiting, gastric lavage, saline laxatives, activated charcoal administration, artificial diuresis, blood alkalization, and symptomatic therapy to preserve vital functions.

Consult your healthcare provider before taking medication. Immediate medical attention is required if an overdose is suspected.

What Should I Do If I Miss a Dose?

If you miss a dose of Analgin 500mg Tablet, take it as soon as possible. However, if it's almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.

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What are the Side Effects of Analgin?

Common Side Effects Include

Serious but Rare Side Effects

  • Kidney damage
  • Dry mouth
  • Low blood pressure
  • Abdominal pain
  • Pink colored urine
  • Choking
  • Agranulocytosis
  • Skin rash
  • Itching
  • Headache
  • Difficulty in swallowing
  • Weakness

Long-term use may necessitate regular monitoring of kidney function, liver function, and blood component levels by your doctor to prevent severe complications like stomach bleeding and kidney problems.

Tips while taking Analgin

  • To alleviate pain, inflammation, and fever, ANALGIN 500MG TABLET is used.
  • Take it with food or milk to reduce stomach pain.
  • Take it as per your doctor's prescribed dosage and length. Severe complications such as stomach bleeding and kidney problems can result from long-term use.
  • If you have a history of heart disease or stroke, tell your doctor.
  • When taking ANALGIN 500MG Pill, stop drinking alcohol as it can increase the risk of stomach problems.
  • If you are taking this medication for long-term care, your doctor may check your kidney function, liver function, and levels of blood components regularly.

Precautions and Warnings while taking Analgin

Discontinue use of Analgin if allergic to it or any inactive ingredients.

Who Should Avoid Analgin?

  • Avoid Analgin in patients with bone marrow disorders, agranulocytosis history, anaemia, eosinophilia, or related disorders.
  • Analgin is not used for patients with hypotension, asthma, or liver disorders.
  • Not recommended for children under 15 years of age.
  • Analgin should not be used during pregnancy or breastfeeding due to potential risks.
  • Not recommended for patients with severe kidney disease.

Conditions Where Caution Is Needed

Analgin injection should be used with caution in patients with these conditions, only under strict medical supervision due to the risk of agranulocytosis.

  • Liver or kidney problems
  • Low blood pressure (hypotension)
  • Asthma or other breathing issues
  • Existing blood disorders
  • Allergies to NSAIDs (like aspirin, ibuprofen)

Are There Any Age Restrictions for Using Analgin?

  • Not recommended for children under 3 months or 5 kg body weight
  • Pediatric doses should only be given under a doctor's guidance

Alcohol or Food Interactions

  • Avoid alcohol while using Analgin, as it can increase the risk of side effects like drowsiness, stomach issues, or liver strain.
  • No significant food interactions, but take with food or after meals if you have a sensitive stomach.

Possible Interactions with Other Medications

Adverse effects can result from the concomitant use of the following drugs:

  • Blood thinners (Warfarin, Acenocoumarol, Heparin)
  • Corticosteroids (Dexamethasone, Prednisolone, Methylprednisolone, Fluticasone)
  • Sulfonamides (Bactrim)
  • Penicillin-like drugs (Ampicillin, Amoxicillin, Amoxiclav)
  • Antidiabetic medications (Metformin, Glibenclamide, Glipyriding)

Injection of Anafortan, when used with antacids, may interfere with Camylofin absorption. Additionally, caution is advised when using Anafortan injection with medications such as Cetirizine, Diphenhydramine, Disopyramide, Quinidine, Pethidine, Amantadine, Amitriptyline, Doxepin, and Phenothiazine, as interactions may occur.

How Should Analgin Be Stored?

  • Store it in an airtight jar.
  • Keep it free from moisture or overt light.
  • Keep it out of children's reach.

Analgin Expired

An adverse effect from a single dose of expired Analgin is unlikely, but it's best to consult your primary healthcare provider or pharmacist if you feel unwell. Expired medication may be ineffective and should not be used. For chronic conditions requiring regular medication, it's important to maintain contact with your healthcare provider to ensure a fresh supply of non-expired drugs.

Recommended Storage Temperature for Analgin:

Store Analgin tablet and injections at a temperature between 15°C to 25°C (59°F to 77°F). Keep it in a cool, dry place, away from direct sunlight, heat, and moisture. Always keep it out of reach of children and pets.

What Happens If Analgin Is Not Stored Properly?

If Analgin is exposed to heat, moisture, or light, it may:

  • Lose effectiveness and not work properly
  • Change in colour, texture, or smell, indicating spoilage
  • Increase the risk of side effects if the chemical composition changes
  • Become unsafe for use beyond its expiry or if stored incorrectly

Always check the expiry date and storage instructions on the label. Discard if the tablet looks discoloured or damaged.

Important Information for Analgin Use

  • Tell your doctor about your current list of medicines, counter-products (e.g. vitamins, herbal supplements, etc.), allergies, pre-existing illnesses and current health problems before using Analgin (e.g. pregnancy, upcoming surgery, etc.).
  • Some health conditions may make you more prone to the drug's side effects.
  • Strictly follow the instructions given on the product or as instructed by your doctor.
  • The dose is dependent on the degree of seriousness of your disease. If your condition continues or aggravates, inform your doctor. Mentioned below are relevant therapy points.

Analgin vs Paracetamol

Analgin Paracetamol
Molecular Formula:C13H18N3NaO5S Formula:C8H9NO2
Formula Weight:333.34 Molar mass:151.163 g/mol
Also known as Dipyron , Dipirone, Novalgin, Sulpyrine Also known as acetaminophen
Is used to treat aches and pains Treats fever and body pain

References

The inhibition action of analgin on the corrosion of mild steel in acidic medium: A combined theoretical and experimental approach
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Frequently Asked Questions

Yes, Analgin is generally considered stronger than paracetamol for pain relief. It is often used for moderate to severe pain and high fever when paracetamol is not effective.

Analgin is also known as Metamizole. In some countries, it may be sold under different brand names like Dipyrone or Novalgin, depending on the manufacturer.

Yes, Analgin can sometimes cause drowsiness or sleepiness as a side effect, especially when taken in higher doses or in sensitive individuals. Avoid driving or using machinery if it makes you drowsy.

No, Analgin is not a steroid. It is a non-opioid analgesic and antipyretic medicine used to relieve pain and reduce fever. It works differently from steroid medications.

The other name for Analgin is Metamizole Sodium. It is used under various brand names worldwide and is known for its strong pain-relieving and fever-reducing properties.


Disclaimer: The information provided is accurate and up-to-date to the best of our knowledge. However, it should not be considered a substitute for medical advice or consultation. We do not guarantee its completeness or accuracy. The absence of specific warnings does not mean a medicine is safe for all users. We are not responsible for any outcomes based on this information and strongly recommend consulting a doctor for any medical concerns or questions.

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