Panlobular Emphysema: Know About The Causes and Treatments

Chronic obstructive pulmonary disease (COPD) encompasses a range of progressive lung conditions, including emphysema. Among the types of emphysema, panlobular emphysema (PLE) stands out for its distinct characteristics and severe impact on respiratory function. This article delves into the nuances of panlobular emphysema, its causes, symptoms, diagnosis and treatment options.


What is Panlobular Emphysema?

Panlobular emphysema (PLE), also known as panacinar emphysema, is a subtype of emphysema characterized by uniform destruction of the alveoli throughout the entire acinus. This contrasts with centrilobular emphysema (CLE), which predominantly affects the central parts of the lobules.

Secure your health with a second opinion. Make informed decisions and book your appointment today!

Get A Second Opinion

Panlobular Emphysema vs. Centrilobular Emphysema

While PLE involves the uniform destruction of alveoli across the entire acinus, CLE primarily affects the central portions of the lobules, sparing the peripheral alveoli. This key difference leads to distinct clinical and radiological presentations, which are crucial for accurate diagnosis and tailored treatment.


Causes of Panlobular Emphysema

Panlobular emphysema is primarily linked to genetic and environmental factors. The most common cause is alpha-1 antitrypsin (AAT) deficiency, a genetic disorder that results in the lack of a crucial protein protecting the lungs from enzymatic damage. Other contributing factors include:

  • Smoking: While smoking is more commonly associated with centrilobular emphysema, it can exacerbate PLE in genetically predisposed individuals.
  • Occupational Exposures: Long-term exposure to dust, chemicals, and other harmful pollutants can contribute to the development of PLE.
  • Chronic Infections: Recurrent respiratory infections can accelerate the destruction of alveoli, worsening the condition.

Symptoms of Panlobular Emphysema

The symptoms of panlobular emphysema are often insidious and progressively worsen over time. Key symptoms include:

  • Shortness of Breath (Dyspnea): Initially occurring during exertion, dyspnea becomes more persistent as the disease progresses.
  • Chronic Cough: A persistent cough, often accompanied by sputum production, is common.
  • Wheezing: A high-pitched whistling sound during breathing, indicative of airflow obstruction.
  • Fatigue: Reduced oxygen exchange can lead to chronic fatigue and reduced exercise tolerance.
  • Weight Loss: Advanced stages of the disease may cause unintended weight loss due to increased energy expenditure from labored breathing.

Diagnosis of Panlobular Emphysema

Accurate diagnosis of panlobular emphysema involves a combination of clinical evaluation, imaging studies, and pulmonary function tests.

Clinical Evaluation

A thorough medical history and physical examination are the first steps. Physicians will assess risk factors, such as smoking history and familial predisposition to AAT deficiency. Physical examination may reveal signs such as barrel chest, use of accessory muscles for breathing, and diminished breath sounds.

Imaging Studies

High-resolution computed tomography (HRCT) is the gold standard for imaging in PLE diagnosis. HRCT scans reveal the extent and pattern of alveolar destruction, helping distinguish PLE from other forms of emphysema.

Pulmonary Function Tests

Pulmonary function tests (PFTs) are essential for assessing the severity of airflow obstruction and lung function. Key parameters measured include forced expiratory volume in one second (FEV1) and forced vital capacity (FVC).

Alpha-1 Antitrypsin Testing

Given the strong association between PLE and AAT deficiency, measuring serum AAT levels is crucial. Genetic testing may also be performed to identify specific mutations in the SERPINA1 gene responsible for AAT production.


Treatment of Panlobular Emphysema

While panlobular emphysema is a chronic and progressive condition, several treatment options can manage symptoms and improve the quality of life.

Lifestyle Modifications

  • Smoking Cessation: Quitting smoking is imperative to slow disease progression and improve lung function.
  • Exercise: Pulmonary rehabilitation programs that include exercise training can enhance respiratory muscle strength and overall endurance.
  • Nutrition: A balanced diet rich in antioxidants and anti-inflammatory foods can support lung health.

Ready to take control of your health journey? Book your appointment now and start your path towards wellness today!

Book an Appointment

Pharmacological Interventions

  • Bronchodilators: Medications that relax the muscles around the airways, making it easier to breathe.
  • Inhaled Corticosteroids: Reduce inflammation and prevent exacerbations.
  • Antibiotics: Used to treat bacterial infections that can exacerbate symptoms.
  • Alpha-1 Antitrypsin Augmentation Therapy: For individuals with AAT deficiency, intravenous infusions of AAT protein can slow disease progression.

Oxygen Therapy

Supplemental oxygen may be prescribed for patients with severe hypoxemia to maintain adequate blood oxygen levels, reduce breathlessness, and improve overall well-being.

Surgical Interventions

  • Lung Volume Reduction Surgery (LVRS): Involves removing diseased portions of the lung, allowing the remaining lung tissue to function more efficiently.
  • Lung Transplantation: Considered for patients with end-stage disease who have not responded to other treatments.

Emerging Therapies

Research is ongoing into novel therapies, including regenerative medicine approaches and gene therapy, which hold promise for more effective management of PLE in the future.


Panlobular Emphysema ICD-10

The International Classification of Diseases, Tenth Revision (ICD-10) provides specific codes for various medical conditions, including panlobular emphysema. The ICD-10 code for panlobular emphysema is J43.1.

Find Our Specialists
Book Doctor Appointment
Book Free Appointment
Make an appointment just in few minutes - Call Us Now

Frequently Asked Questions

1. What are the symptoms of panlobular emphysema?

Symptoms include shortness of breath, chronic cough, and wheezing.

2. What causes panlobular emphysema?

Causes include long-term smoking, genetic conditions like alpha-1 antitrypsin deficiency, and exposure to pollutants.

3. How is panlobular emphysema treated?

Treatment involves bronchodilators, oxygen therapy, and lifestyle changes like quitting smoking.

4. What is the difference between panlobular and centrilobular emphysema?

Panlobular affects the entire lung lobe, while centrilobular affects the upper parts of the lung.

5. How is panlobular emphysema diagnosed?

Diagnosis is made through imaging tests like X-rays and pulmonary function tests.

Whats app Health Packages Book an Appointment Second Opinion