A Quick Guide to Dolo 650 Composition and Safety

Dolo 650 is a widely used medication known for its analgesic and antipyretic properties. Its primary active ingredient is paracetamol, also known as acetaminophen. The article tries to explore the chemical and pharmacological aspects of Dolo 650. We will explore its composition, chemical formula, and potential drug interactions.

Whether you're a medical professional, a pharmacology student, or an individual seeking in-depth knowledge about this medication, this article will provide valuable insights. Let's begin our exploration of the composition of Dolo 650.

The Active Components of Paracetamol

Each Dolo 650 tablet contains 650 mg of paracetamol. This compound is the driving force behind the medication's pain-relieving and fever-reducing effects. Paracetamol inhibits the synthesis of prostaglandins, chemicals that play a vital role in the body's pain and fever responses.

It's important to note that Dolo 650 does not possess anti-inflammatory properties. This differentiates it from nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen and aspirin.

The medication is available over-the-counter and by prescription in some countries. It's often prescribed for the relief of mild to moderate pain and fever.

The inactive ingredients in Dolo 650 may vary by manufacturer. Commonly, they include starch, magnesium stearate, and povidone.

Chemical Formula of Paracetamol

The chemical formula of Paracetamol, the active component in Dolo 650, is C8H9NO2. This formula represents a compound with eight carbon atoms, nine hydrogen atoms, one nitrogen atom, and two oxygen atoms.

Paracetamol is metabolized primarily in the liver. It undergoes conjugation and oxidation reactions, which are crucial for its therapeutic action.

Paracetamol's metabolites are excreted primarily in the urine. The half-life of Paracetamol in healthy adults is about 2 to 3 hours.

Dolo 650 Dosage and Pharmacokinetics

Each Dolo 650 tablet contains 650 mg of paracetamol. The medication is often prescribed for the relief of mild to moderate pain and fever. The onset of action for Dolo 650 is typically within an hour. Peak effects occur between 1 to 3 hours after ingestion.

The recommended dosage of Dolo 650 must not be exceeded. Overdosing can lead to severe liver failure and requires immediate medical attention. Patients should consult with a healthcare provider before starting or stopping Dolo 650, especially if they are taking other medications.

Potential Drug Interactions with Dolo 650

Dolo 650 may interact with other drugs, leading to potential health risks. For instance, it can interact with Warfarin, a blood-thinning medication. This interaction can increase the risk of bleeding. Therefore, patients on Warfarin should use Dolo 650 with caution.

Chronic alcohol use may also increase the risk of liver damage when taking Dolo 650. This is due to the increased strain on the liver from metabolizing both substances.

Here are some drugs that may interact with Dolo 650:

Always consult a healthcare provider before combining Dolo 650 with other medications.

Safety Profile and Contraindications

Dolo 650 is generally considered safe for most individuals. However, it should be used with caution in patients with liver or kidney impairment. An overdose of Dolo 650 can lead to severe liver failure. Immediate medical attention is required in such cases.

Dolo 650 is contraindicated in patients with known hypersensitivity to Paracetamol. It should also be avoided by patients with a history of alcohol abuse due to the increased risk of liver damage. Always consult a healthcare provider before starting or stopping Dolo 650, especially if taking other medications.

Frequently Asked Questions