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Tiagabine

tiagabine

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By Medicover Hospitals / 10 Mar 2021
Home | Medicine | Tiagabine

What is Tiagabine ?

  • Tiagabine is a medication that is used in conjunction with other medications to treat partial seizures (a type of epilepsy). It belongs to the anticonvulsant medication class. Tiagabine's exact mechanism of action is unknown, but it increases the number of natural chemicals in the brain that prevents seizure activity.
    1. Tiagabine Uses
    2. Tiagabine Side effects
    3. Precautions
    4. Overdose
    5. Storage
    6. Tiagabine vs Gabapentin
    7. Frequently Asked Questions
    8. Citations

    Tiagabine Uses:

  • Tiagabine is a medication, used in conjunction with some other medications to treat certain types of seizures (focal seizures). It works by preventing seizure activity from spreading throughout the brain. This medication is classified as an anticonvulsant or anti-epileptic medication. Serious reactions (including seizures in people who had never had them) have occurred when tiagabine has been used for conditions other than epilepsy.
  • How to use Tiagabine HCL

    • Before you begin taking tiagabine, and each time you get a refill, read the Medication Guide provided by your pharmacist.
    • As directed by your doctor, take this medication orally with food. To reduce the possibility of side effects, your doctor may advise you to begin this medication at a low dose and gradually increase it. This medication is usually taken once a day during the first week of treatment. Your doctor may increase your dose to 2 to 4 times daily in the coming weeks.
    • Tiagabine is rarely used on its own. Stop taking any other kind of anti-seizure medication unless your doctor tells you to do so.
    • To get the most out of this medication, take it on a regular basis. Take it at the same time.
    • When this drug is abruptly discontinued, some conditions (such as seizures) may worsen. It is possible that your dose will need to be gradually reduced.
    • If you stop taking this medication for an extended period of time, consult your doctor about how to restart it. You may need to start with a low dose and gradually increase it again.

    Tiagabine Side Effects:

    • Dizziness
    • Lightheadedness
    • Drowsiness
    • Lack of energy or weakness
    • Wobbliness, unsteadiness, or incoordination causing difficulty walking
    • Depression
    • Anger
    • Irritability
    • Confusion
    • Difficulty concentrating
    • Abnormal thinking
    • Speech or language problems
    • Increased appetite
    • Nausea
    • Stomach pain
    • Nervousness
    • Difficulty falling asleep or staying asleep
    • Itching
    • Bruising
    • Painful or frequent urination

    Precautions:

    • Tell your doctor or pharmacist if you are allergic to tiagabine or if you have any other allergies before taking it. Inactive ingredients in this product might cause allergic reactions or other problems.
    • Tell your doctor or pharmacist about your medical history, especially if you have: liver disease, mental/mood disorders (such as depression, suicidal thoughts), or a seizure that does not stop (status epilepticus).
    • Older adults may be more sensitive to the drug's side effects, particularly dizziness or confusion. These effects may increase the likelihood of falling.
    • This medication should be used only when prescribed by the doctor during pregnancy. Discuss the benefits and drawbacks.

    Interactions:

    • Orlistat is a product that may interact with this medication.
    • Inform your doctor or pharmacist if you are taking any other drowsy products, such as alcohol, antihistamines, sleep or anxiety medications, muscle relaxants, or opioid pain relievers.
    • Check the labels of all your medications because they may contain drowsy ingredients. Inquire with your pharmacist about how to use those products safely.

    Overdose:

  • If someone has taken an overdose of this medicine and has serious symptoms such as passing out or trouble breathing, seek medical advice. Never take more than what is prescribed to you by your doctor.
  • Missed Dose:

  • If you forget to take any dose, take it as soon as you remember it. If it is already the time for the next dose, skip the forgotten dose. Take your next medicine at the regular time schedule. Do not double the dose.
  • Storage:

  • The medicine should not come in direct contact with heat, air, and light may damage your medicines. Exposure to medicine might cause some harmful effects or serious side effects. The medicine must be kept in a safe place and out of children’s reach.
  • Tiagabine vs Gabapentin:

    Tiagabine
    Gabapentin
    Tiagabine belongs to the anticonvulsant medication class. Gabapentin is available as the brand-name drug Neurontin. It is available as a generic drug.
    Tiagabine is a medication that is used in conjunction with other medications to treat partial seizures (a type of epilepsy). Gabapentin oral capsule is prescribed for the treatment of partial seizures in adults and children.
    It works by preventing seizure activity from spreading throughout the brain. It is also used to treat nerve pain that is caused by shingles.

    Frequently Asked Questions:

    Tiagabine is a medication that is used in conjunction with other medications to treat partial seizures (a type of epilepsy). Tiagabine belongs to the anticonvulsant medication class.
    Tiagabine hydrochloride is indicated as adjunctive therapy in the treatment of partial seizures in adults and children 12 years of age and older.
    The most common side effects are
    • Dizziness
    • Lightheadedness
    • Drowsiness
    • Lack of energy or weakness
    • Wobbliness, unsteadiness, or incoordination causing difficulty walking
    • Depression
    • Anger
    It may or may not cause depression. It depends on the medical condition and health of the patient.
    In patients with GAD, tiagabine has significantly reduced anxiety and comorbid depressive symptoms also had improved sleep quality and functioning well.
    There is a risk that you will experience changes in your mental health if you take an anticonvulsant medication like tiagabine, but there is also a risk that your condition will not be treated.
    Tiagabine comes under the trade name Gabitril, an anticonvulsant medication used to treat epilepsy. Off-label use of the drug includes the treatment of anxiety disorders and panic disorder.
    Action Mechanism- Tiagabine is thought to block GABA uptake into presynaptic neurons, allowing more GABA to be available for receptor binding on the surfaces of postsynaptic cells. GABA uptake has been shown to be inhibited in synaptosomes, neuronal cell cultures, and glial cell cultures.

    Citations:

  • Tiagabine , https://link.springer.com/article/10.2165/00003495-199855030-00013
  • Tiagabine for Treatment, https://www.psychiatrist.com/jcp/anxiety/anxiolytics/tiagabine-treatment-generalized-anxiety-disorder-randomized/