Orlistat: Uses, Benefits, and Side Effects
Written by Medicover Team and Medically Reviewed by Dr Kandala Sindhuja Reddy, Endocrinology
Orlistat medication, including orlistat 60, orlistat 120, and orlistat capsules, is used to treat obesity by blocking fat absorption from food and reducing calorie intake. It stops pancreatic lipase, an enzyme that breaks down fats in the gut. Without it, fats pass through undigested.
Orlistat is a prescription weight-loss medicine that helps block the absorption of fat from the food you eat. It is available in forms like orlistat 60 mg, orlistat 120 mg, orlistat tablets, and orlistat capsules. This medicine is commonly used under brand names such as Xenical or Alli.
Orlistat tablet uses mainly include aiding weight loss and preventing weight regain in overweight individuals. It works best when combined with a low-fat diet and exercise. Orlistat 120 mg is particularly effective in the treatment of clinical obesity. Orlistat tablets may also be used to improve cholesterol and blood pressure levels.
While primarily prescribed for weight management, orlistat medicine may also be used in patients with risk factors for metabolic syndrome. Doctors sometimes recommend it for long-term orlistat weight loss support in individuals who struggle with maintaining reduced weight.
Orlistat side effects can include oily stools, gas with discharge, and abdominal cramps, especially if taken with high-fat meals.
Orlistat works by blocking an enzyme in your digestive system called lipase. This enzyme helps break down fat from food. When orlistat capsules or orlistat tablets are taken with meals, they prevent about 25 30% of dietary fat from being absorbed. Instead, the fat passes through the body undigested and is eliminated in the stool.
Unlike many other weight-loss drugs, orlistat medicine does not affect the brain, hormones, or nervous system. It acts locally in the gut, which is why it has fewer systemic side effects compared to appetite-suppressing drugs.
The typical dose of orlistat 120 mg is one capsule taken with each main meal that contains fat, up to three times a day. Orlistat tablets or orlistat capsules should be taken during or within one hour after a meal. Always follow your doctor's dosage instructions for best results.
If you miss a dose of orlistat medicine, skip it if more than an hour has passed since your meal. Do not take two doses at once to make up for it.
Overdosing on orlistat is rare but can increase the risk of side effects such as stomach pain, diarrhea, or difficulty controlling bowel movements.
If an overdose is suspected, seek immediate medical help.
Get a second opinion from trusted experts and makeconfident, informed decisions.
Get Second OpinionWhile effective, the Harmful effects of Orlistat diet pills may occur, especially when taken with high-fat meals
It's important to contact your doctor immediately if you experience any serious symptoms due to Orlistat. Remember, your doctor prescribed this medication because they judged that the benefits outweigh the risks.
The majority of the people who use this medicine don't show any side effects. Get medical help immediately if you get any serious Orlistat side effects.
Before using Orlistat, talk with your doctor if you are allergic to it or any other medications. The product may contain an inactive ingredient that can cause allergic reactions or other serious problems.
Before using Orlistat, talk with your doctor if you have any medical history, such as:
This applies whether you're taking orlistat medication in capsule or tablet form, including orlistat 60 or orlistat 120.
Orlistat capsules and orlistat tablets should be stored at room temperature, between 20°C to 25°C (68°F to 77°F). Keep the medicine in its original container, tightly closed, and away from direct sunlight, heat, and moisture.
Important Storage Tips:
Improper storage may reduce the effectiveness of orlistat medicine and increase the risk of unwanted orlistat side effects.
| Orlistat | Phentermine |
| Orlistat is a medication used to treat obesity. It works by blocking fat absorption in the digestive system, helping reduce overall calorie intake. | Phentermine is an amphetamine-like drug that suppresses appetite, helping users feel full and eat less. |
| Used along with a low-calorie, low-fat diet and exercise. Often prescribed to people who are overweight and have high blood pressure, diabetes, or heart disease. | Used with a doctor-approved diet, exercise, and behaviour plan. Recommended for people who are obese or have weight-related health problems. |
Serious Side Effects:
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Serious Side Effects:
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040-68334455Long-term side effects may include oily stools, vitamin deficiencies, liver issues, and rare kidney problems with prolonged us
Orlistat blocks fat absorption in the gut, helping reduce calorie intake and supporting weight loss when used with a low-fat diet.
Orlistat blocks fat absorption, while Phentermine curbs appetite. Effectiveness varies; a doctor can suggest the best option for you.
With Orlistat and a low-fat diet, you may lose 1–2 pounds per week, depending on your lifestyle, diet, and activity level.
Hair loss is not a common side effect of Orlistat, but nutritional deficiencies from fat malabsorption may contribute in rare cases.
Disclaimer: The information provided is accurate and up-to-date to the best of our knowledge. However, it should not be considered a substitute for medical advice or consultation. We do not guarantee its completeness or accuracy. The absence of specific warnings does not mean a medicine is safe for all users. We are not responsible for any outcomes based on this information and strongly recommend consulting a doctor for any medical concerns or questions.