Allantoin: Uses, Dosage, Side Effects, and Precautions

Allantoin is a naturally occurring additive found in several over-the-counter (OTC) skin care products. It is extracted from plants such as:

• Beets
• Comfrey
• Chamomile
• Wheat Sprouts
• Tobacco Seeds

If you are dealing with dryness, dullness, irritation, acne scars, and cuts or scrapes, Allantoin can be an effective solution for your skin.

What are the Uses of Allantoin?

Conditions Allantoin is Used to Treat

• Moisturizer for Dry Skin: Allantoin is commonly used to treat dry, rough, scaly, and itchy skin. It helps by forming an oily layer on top of the skin to trap moisture.
• Reducing Itching and Flaking: Allantoin decreases itching and flaking, providing relief from discomfort caused by dry skin and minor irritations.
• Protection Against Irritation: Ingredients like zinc oxide and white petrolatum, along with Allantoin, form a barrier to protect the skin from further irritation and environmental damage.
• Hydration: Allantoin retains moisture in the skin, preventing dryness by reducing water loss from the upper layer.
• Therapeutic Use: It is effective in treating minor skin irritations, rashes and burns from radiation therapy, promoting skin recovery and comfort.

Secondary Benefits of Allantoin

Allantoin is also used in:

• Acne treatment creams
• Anti-aging products
• Products for treating skin peeling or scaling

How to Use Allantoin Cream?

Follow these instructions for using Allantoin effectively:

• Use the product as directed by your doctor. Some products may require priming before use. Follow the directions on the product package carefully.
• Shake some products before use. Check the label to see if shaking is necessary.
• Apply Allantoin to the affected areas of the skin as directed on the label or by your doctor. The frequency of application depends on the skin condition. For instance, for dry hands, apply the product every time after washing hands.
• If using for diaper rash, clean the diaper area before application and ensure it is dry.
• Consult with radiation personnel to determine if the product should be applied before radiation therapy.
• Be cautious and avoid applying Allantoin to sensitive areas such as the mouth, face, nose, vaginal area, and eyes.
• Use Allantoin regularly to maximize its benefits. Apply it after a shower to moisturize the skin effectively.

Follow the directions on the label for the proper use of the product to achieve optimal results.

How Does Allantoin Work?

Allantoin promotes skin cell regeneration and helps retain moisture. It acts as a skin protectant and softens keratin, which helps dead skin cells shed naturally.

Mechanism of Action

Allantoin helps your skin heal faster. It keeps the skin moist, reduces irritation, and encourages the growth of new, healthy skin cells. It does not directly affect hormones or the nervous system, as it works topically on the skin s surface.

Dosage of Allantoin

What Should I Do If I Miss a Dose?

• No Immediate Problem: A missed dose of Allantoin typically does not cause immediate problems. However, with certain medications, missing a dose can affect treatment efficacy.
• Potential Effects: Missing a dose may lead to sudden chemical changes in the body. If you miss a dose, your doctor may advise you to take it as soon as possible.

What happens if an Overdose?

Accidental Risk: Overdosing on Allantoin can occur accidentally. Taking more than the prescribed amount can harm your body's functions and may lead to a medical emergency.

Symptoms of Overdose

• Redness or itching
• Rash or burning sensation
• Discomfort or sensitivity

What Are the Side Effects of Allantoin?

Allantoin is generally safe and well-tolerated, but some individuals may experience the following side effects

Common Side Effects

• Burning Sensation
• Stinging
• Redness
• Skin Irritation

Serious but Rare Side Effects

• Swelling
• Rash
• Difficulty breathing

If you encounter any of these symptoms, it is advisable to discontinue the use of it and consult your doctor promptly for appropriate guidance. While most users do not experience side effects, it's essential to prioritize your health and seek medical assistance if serious reactions occur.

Precautions of Allantoin

Before starting to use Allantoin, consider the following precautions:

• Allergies: Inform your doctor about any allergies to ingredients in the product or other medications. Inactive ingredients can sometimes cause allergic reactions or other complications.
• Skin Conditions: Consult your doctor if you have skin cuts, infections, or sores before using Allantoin. Certain ingredients like preservatives and fragrances may increase skin sensitivity.
• Acne Sensitivity: If your skin is prone to acne breakouts, check for products labeled "non-comedogenic" to avoid exacerbating acne. Seek guidance from your doctor for more information about suitable products.

Warnings for Serious Health Conditions

Pregnancy

• Limited Research: There is insufficient research on the use of Allantoin cream during pregnancy. Consult your doctor before using it to ensure safety and benefits.

Breastfeeding

• Limited Data: There is limited data on the use of Allantoin cream while breastfeeding. Use caution when applying near the breast area to avoid potential harm to your baby.

Who Should Avoid This Medicine

• People allergic to Allantoin or any component in the formulation
• Use with caution on broken or infected skin

Possible Interactions of Allantoin with Other Medications

• Minimal Interaction Risk: Allantoin is used topically and is not significantly absorbed into the bloodstream. It has a very low risk of interacting with oral or injectable medications.
• When Used with Other Topical Products: May cause irritation if combined with: Retinoids (like tretinoin), Alpha hydroxy acids (e.g., glycolic acid), Beta hydroxy acids (e.g., salicylic acid), Strong exfoliants or chemical peels
• Herbal Product Interactions: Herbal creams or oils with active ingredients (e.g., tea tree oil, neem, clove) may increase the risk of skin sensitivity or allergic reactions.
• Supplement Interactions: No known interactions with dietary supplements when used topically. Always inform your doctor about any supplements you're taking.

How Should Allantoin Be Stored?

Direct contact with heat, air and light may damage your medicines. The exposure of medicine may cause some harmful effects. The medicine must be kept in a safe place and out of children s reach.

Recommended Storage Temperature

Mainly, the drug should be kept at room temperature between 68ºF and 77ºF (20ºC and 25ºC).

What Happens If Not Stored Properly?

Improper storage may:

• Reduce the effectiveness of the product
• Change its texture, color, or smell
• Lead to contamination or spoilage

Before taking Allantoin, consult your Doctor. In case you face any problems or get any side effects after taking Allantoin, rush immediately to your nearby hospital or consult your doctor for better treatment. Always carry your medications with you in your bag when traveling to avoid any immediate emergencies. Follow your prescription and follow your doctor's advice whenever you take Allantoin.

Allantoin vs Tretinoin

References

Comparison of efficacy of silicone gel, silicone gel sheeting, and topical onion extract including heparin and allantoin for the treatment of postburn hypertrophic scars