Acquired Syphilis- Causes, Symptoms, and Care

Written by Medicover Team and Medically Reviewed by Dr Girishma J , Dermatologists



Acquired syphilis is a sexually transmitted infection caused by the bacterium Treponema pallidum. This disease is typically spread through sexual contact with an infected individual. However, it can also be transmitted from a mother to her unborn child during pregnancy. Syphilis progresses in stages, with the initial stage presenting as a painless sore called a chancre at the site of infection. If left untreated, the infection can progress to the secondary and tertiary stages, potentially causing serious complications. Prevention of syphilis involves practicing safe sex by using condoms and being in a mutually monogamous relationship with a partner who is not infected.


What Are the Types Of Acquired Syphilis?

Acquired syphilis presents in several distinct stages, starting with primary syphilis characterized by painless sores at the infection site. This progresses to secondary syphilis, marked by skin rashes, mucous membrane lesions, and flu-like symptoms.

If left untreated, the disease can advance to latent syphilis, where no symptoms are apparent but the bacteria remain in the body. Tertiary syphilis is the most severe stage, potentially leading to organ damage, cardiovascular complications, and neurological issues. Monitoring and treatment at each stage are crucial to prevent long-term complications and transmission of the infection.

  • Latent syphilis may have no visible symptoms but the infection is still present in the body.
  • Tertiary syphilis can lead to severe complications such as cardiovascular syphilis, neurosyphilis, and gummatous syphilis.
  • Neurosyphilis affects the nervous system and can lead to various neurological symptoms.
  • Ocular syphilis can cause inflammation of the eye structures and potentially lead to vision problems.

What Are the Symptoms of Acquired Syphilis

Acquired syphilis can present with a variety of symptoms that may appear in different stages. In the primary stage, a painless sore called a chancre may develop at the site of infection. As the infection progresses to the secondary stage, symptoms like a rash, fever, sore throat, and swollen lymph nodes can occur.

If left untreated, syphilis can progress to the latent and tertiary stages, leading to severe complications affecting the heart, brain, and other organs. It's important to promptly seek medical attention if you suspect you may have syphilis to receive appropriate treatment and prevent further health issues.

  • The primary symptom of acquired syphilis is the development of a painless sore called a chancre at the site of infection.
  • As the infection progresses, individuals may experience a rash that can appear on the palms of the hands or soles of the feet.
  • Other symptoms of acquired syphilis can include flu-like symptoms such as fever, swollen lymph nodes, and fatigue.
  • In later stages, untreated syphilis can cause serious complications like cardiovascular issues and damage to the brain and other organs.

What Are the Causes of Acquired Syphilis?

Acquired syphilis is primarily caused by the bacterium Treponema pallidum, typically transmitted through sexual contact with an infected individual. The disease can also be spread through blood transfusions or from an infected mother to her unborn child during pregnancy (congenital syphilis).

Risk factors for acquiring syphilis include unprotected sexual activity with multiple partners, engaging in high-risk sexual behaviors, and having a history of sexually transmitted infections. Early detection and treatment are crucial to prevent complications and further transmission of the infection.

  • Unprotected sexual contact with an infected person is a common cause of acquired syphilis.
  • Sharing contaminated needles or syringes for drug use can lead to the transmission of syphilis.
  • Blood transfusions involving infected blood can be a source of acquiring syphilis.
  • Vertical transmission from an infected mother to her unborn child during pregnancy or childbirth can cause syphilis.
  • Rarely, direct contact with syphilitic sores during sexual activities can result in the acquisition of syphilis.

When to See a Doctor?

If you notice sores, rashes, or other unusual symptoms, consult an Infectious Disease Specialist or Dermatologist. Early diagnosis prevents severe complications affecting the heart, brain, and nervous system.

You should see a doctor if you have:

  • Painless sores (chancres) on the genitals, mouth, or rectum that do not heal on their own.
  • A non-itchy rash on the palms, soles, or body, along with flu-like symptoms such as fever and fatigue.

Get medical help immediately if:

  • You experience sudden neurological symptoms such as severe headaches, vision loss, confusion, or difficulty walking.
  • You develop chest pain, shortness of breath, or signs of cardiovascular distress linked to untreated syphilis.
  • You are pregnant and suspect syphilis exposure, as it can cause serious harm to your unborn baby.

These could be signs of a serious complication like Neurosyphilis, which needs urgent care.

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How is the Diagnosis of Acquired Syphilis Performed?

Diagnosing Acquired Syphilis typically involves a combination of methods. Firstly, healthcare providers may conduct a physical examination to look for characteristic signs like sores or rashes. Blood tests such as the Venereal Disease Research Laboratory (VDRL) or Rapid Plasma Reagin (RPR) tests are commonly used to detect antibodies produced in response to the infection.

In some cases, a sample of fluid from a sore may be analyzed under a microscope. Additionally, advanced tests like the Treponemal test can confirm the presence of the bacterium that causes syphilis. These diagnostic approaches help healthcare professionals accurately identify and treat Acquired Syphilis.

  • Serologic tests, including nontreponemal and treponemal tests, are commonly used for diagnosing acquired syphilis.
  • Nontreponemal tests such as RPR and VDRL are initial screening tests for acquired syphilis.
  • Treponemal tests like TP-PA and EIA are confirmatory tests used to detect specific antibodies in acquired syphilis.
  • Darkfield microscopy can directly visualize the spirochetes in lesions for diagnosing early acquired syphilis.
  • Polymerase chain reaction (PCR) testing may be used to detect the DNA of Treponema pallidum in acquired syphilis cases.

What is the Treatment for Acquired Syphilis?

Treatment options for acquired syphilis typically involve antibiotics, with penicillin being the preferred choice. The specific antibiotic regimen and duration depend on the stage of the disease. Early-stage syphilis is usually treated with a single dose of penicillin, while advanced cases may require multiple doses over a longer period.

Close monitoring and follow-up are essential to ensure the infection is fully eradicated. In some cases, individuals who are allergic to penicillin may be prescribed alternative antibiotics. It's crucial to complete the full course of treatment as prescribed by a healthcare provider to effectively cure syphilis and prevent complications.

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Prevention of Acquired Syphilis

Prevention of acquired syphilis focuses on reducing exposure to the bacteria that cause the infection and practicing safe sexual behaviors. Early testing and treatment are essential to prevent transmission and long-term complications.

  • Practice safe sex: Use condoms consistently and correctly during sexual activity to reduce the risk of infection.
  • Limit sexual partners: Reducing the number of sexual partners lowers the chance of exposure to syphilis.
  • Get regular STI screenings: Routine testing helps detect syphilis early, especially in sexually active individuals.
  • Avoid sexual contact with infected individuals: Refrain from sexual activity until infected partners have completed treatment.
  • Seek prompt treatment: Early treatment of syphilis prevents transmission and disease progression.
  • Inform and treat sexual partners: Partner notification and treatment help prevent reinfection and further spread.
  • Attend prenatal screening: Pregnant women should undergo syphilis testing to prevent congenital infection.

Recovery from Acquired Syphilis

Recovery from acquired syphilis is generally excellent when the infection is diagnosed early and treated appropriately with antibiotics. The recovery process depends on the stage of the disease and the presence of any complications.

  • Early treatment improves outcomes: Prompt antibiotic therapy can cure the infection and prevent disease progression.
  • Symptoms gradually resolve: Sores, rashes, and other symptoms typically improve within weeks after treatment.
  • Regular follow-up testing: Blood tests are needed to confirm treatment success and monitor recovery.
  • Avoid sexual activity during treatment: This helps prevent transmission and reinfection.
  • Partner evaluation and treatment: Sexual partners should be tested and treated if necessary.
  • Recovery time varies: Most individuals recover fully, but advanced stages may require longer monitoring.
  • Manage complications promptly: Early intervention for neurological or cardiovascular involvement improves long-term outcomes.

Frequently Asked Questions

1. What are the common signs of Acquired Syphilis?

Common signs of Acquired Syphilis include painless sores, rash, fever, and swollen lymph nodes.

2. Are there specific things I should or shouldn't do when dealing with Acquired Syphilis?

Yes, do seek medical treatment promptly. Avoid sexual contact until treatment is complete to prevent spreading the infection.

3. What serious complications could arise from Acquired Syphilis?

If left untreated, Acquired Syphilis can lead to serious complications such as damage to the heart, brain, nerves, and other organs.

4. How can Acquired Syphilis be treated and controlled?

Acquired syphilis can be treated and controlled with antibiotics, particularly penicillin, prescribed by a healthcare provider. Early treatment is crucial to prevent complications and transmission to others.

5. How can I prevent the recurrence of Acquired Syphilis?

Use condoms during sexual activity, get tested regularly, and complete the recommended antibiotic treatment to prevent recurrence of Acquired Syphilis.

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