Adenosine Deaminase Test

The adenosine deaminase test is a popular biochemical test used to evaluate the levels of Adenosine Deaminase (ADA) enzyme in bodily fluids such as sputum, cerebrospinal fluids, pleural fluids, synovial fluids, ascites, and blood serum.

ADA is a vital enzyme found in the body that accomplishes the following tasks:

The ADA test measures the levels of ADA enzymes in pleural fluids or serum, which are produced in greater quantities as an immunological response during TB and aid in the early detection of the illness.

What are the uses of the Adenosine Deaminase test?

The ADA test is most commonly used to detect tuberculosis. The condition is caused by the Mycobacterium Tuberculosis bacteria, which infects the lungs and causes a buildup of excess pleural fluids or pleural inflammation. The ADA enzyme is responsible for inducing a T-lymphocytic response to the pathogenic invasion, resulting in an increase in ADA production inside the pleural cavity.

What is the need for an Adenosine Deaminase Test?

Adenosine Deaminase testing is commonly used to diagnose tuberculosis (TB), but it may also be used to detect infections in cerebral and peritoneal fluids.

The exam is also used to screen certain groups of people, including:

  • Health professionals that work with TB patients
  • Individuals leaving tuberculosis-infested areas
  • Women who are pregnant
  • Children with a positive TB screening test immunocompromised patients.

What happens during Adenosine Deaminase Test?

The ADA test includes collecting pleural fluid from the chest pleural cavity. The aspirate is drained through a tube after a needle is inserted between the pleural membranes protecting the chest and lungs. This fluid is subsequently sent to the laboratory for immunoassay.

How to prepare for the ADA test?

There is no required preparation for an ADA exam. If you take any medications, you must notify your doctor since some compounds, such as blood thinners, may interfere with the test.

If you are having the test, it is best to have someone accompany you home because the anesthesia used during the test may cause dizziness.

Understanding the Adenosine Deaminase Test results

ADA activity greater than 43U/ml in pleural fluids indicates pleural tuberculosis with 81- 100% sensitivity and greater than 83% specificity.
Higher ADA values also may be caused by health conditions, such as pulmonary embolism, lupus,lymphomas, sarcoidosis, and other parapneumonic and vascular diseases. However, the ADA values in these cases are slightly higher.

Frequently Asked Questions

1. What is the Adenosine Deaminase (ADA) Test?

The ADA test is a blood test that measures the amount of adenosine deaminase in the blood. This enzyme is important in the development and function of the immune system, and low levels of ADA can be a sign of immune deficiency disorders.

2. Why is the ADA Test done?

The ADA test is most commonly used to diagnose tuberculosis, as TB can cause an increase in ADA levels. It can also help diagnose other conditions, such as lymphoma, autoimmune disorders, and viral infections.

3. How is the ADA Test performed?

The ADA test is a simple blood test that is performed by drawing blood from a vein in your arm. The sample of blood is sent to a laboratory for analysis.

4. Is there any preparation required for the ADA Test?

There is no specific preparation required for the ADA test. However, your doctor may ask you to avoid certain medications before the test, as they can affect the results.

5. What do the results of the ADA Test mean?

The normal range for ADA levels can vary depending on the laboratory performing the test, but generally, a level of less than 30 U/L is considered normal. Higher levels of ADA can indicate the presence of certain conditions, such as tuberculosis or lymphoma.

6. Are there any risks associated with the ADA Test?

There are no significant risks associated with the ADA test. Some people may experience slight bruising or bleed in the area where the blood was drawn, but this is generally minor and resolves quickly.

7. How long does it take to get the results of the ADA Test?

The time it takes to get the results of the ADA test can vary depending on the laboratory performing the test. In most cases, results are available within a few days to a week. Your doctor will inform you of the results and what they mean for your health.

8. Why is ADA elevated in tuberculosis?

Adenosine deaminase (ADA) has been discovered and is commonly utilized in the diagnosis of tuberculosis (TB). ADA is an enzyme that rises in TB due to mycobacterial antigen activation of T-cell cells.

9. What is the ADA test cost?

The ADA test price ranges approximately from Rs. 300 to Rs. 600. The price may differ from place to place.

10. Where can I get ADA test?

You can get an ADA test at Medicover Hospitals.