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By Medicover Hospitals / 22 Mar 2021
Home | Medicine | Zonisamide

What is Zonisamide?

  • Zonisamide is marketed under several brand names, including Zonegran. Zonisamide is a carbonic anhydrase inhibitor and a sulfonamide anticonvulsant that is used as an adjunctive treatment for partial seizures in adults with epilepsy.
    1. Zonisamide Uses
    2. Zonisamide Side effects
    3. Precautions
    4. Overdose
    5. Storage
    6. Zonisamide vs lacosamide
    7. Frequently Asked Questions
    8. Citations

    Zonisamide Uses:

  • Zonisamide is a medication that is used in conjunction with some other medications in order to prevent and control seizures (epilepsy). It is a carbonic anhydrase inhibitor and a sulfonamide anticonvulsant.
  • How to use

    • Before you begin taking zonisamide, and each time you get a refill, read the Medication Guide provided by your pharmacist.
    • Take this medication orally as prescribed by your doctor, typically 1 to 2 times per day with or without food. Drink plenty of liquids while taking this medication to avoid the formation of kidney stones, unless your doctor instructs you otherwise.
    • The dose is determined by your medical condition and response to treatment. It is critical to strictly adhere to your doctor's dosing instructions. Your doctor will start on a low dosage and gradually increase it over time. It could take several weeks or months to find the right dose for you and reap the full benefits of this medication.
    • To get the most out of this medication, take it on a regular basis. This medication works best when the amount of medicine in your body is kept constant. Take zonisamide at the same time(s) every day to help you remember and maintain a consistent level.
    • Do not discontinue this medication before even consulting your doctor. Some conditions may worsen if the drug is abruptly discontinued. It is possible that your dose will need to be gradually reduced.

    Zonisamide Side Effects:

    • Headache
    • Nausea
    • Agitation
    • Abdominal pain
    • Confusion
    • Depression
    • Double vision
    • Trouble sleeping
    • Diarrhea
    • Flu-like symptoms
    • Kidney stones
    • Numbness and tingling
    • Changes in taste
    • Weight loss
    • Anxiety
    • Rash
    • Constipation
    • Runny or stuffy nose
    • Dry mouth
    • Tired feeling
    • Sore throat
    • Cough
    • Blurred vision


    • Tell your doctor or pharmacist if you are allergic to zonisamide or if you have any other allergies. Inactive ingredients present in this product may cause allergic reactions or other problems.
    • Tell your doctor or pharmacist about your medical history, especially if you have: liver disease, kidney disease (such as kidney stones), lung/breathing problems, long-term diarrhea, metabolic imbalance (metabolic acidosis), a special diet (ketogenic diet), or mental/emotional problems (such as depression, psychosis).
    • This medication may cause you to sweat less, increasing your risk of heatstroke. Avoid activities that may cause you to overheat, such as strenuous work or exercise in hot weather, as well as using hot tubs. Drink plenty of fluids and dress lightly when the weather is hot. If you have a persistent fever, mental/mood changes, a headache, or dizziness, seek medical attention right away.
    • This medication's side effects, mainly dizziness, lightheadedness, and lack of coordination, may be more severe in older adults.
    • Children may be more sensitive to the drug's side effects.
    • This medication should not be used during pregnancy. It can harm an unborn child. However, because untreated seizures are a serious condition that can harm both a pregnant woman and her unborn child, do not stop taking this medication unless your doctor tells you to. If you are planning a pregnancy, consult your doctor immediately about the benefits and risks of using this medication during pregnancy.
    • This medication is excreted in breast milk. Before breastfeeding, talk to your doctor.


  • Carbonic anhydrase inhibitors (such as acetazolamide) and orlistat are examples of products that may interact with this medication. Other medications may interfere with the removal of zonisamide 110mg from your body, affecting how zonisamide works. If you are taking other medications, your doctor may need to adjust your zonisamide dose. Inform your doctor or pharmacist if you are taking any other products that cause drowsiness, such as alcohol, antihistamines, sleep, or anxiety medications.
  • Overdose:

  • If someone has taken an overdose of this medicine and has serious symptoms such as passing out or trouble breathing, seek medical advice. Never take more than what is prescribed to you by your doctor.
  • Missed Dose:

  • If you forget to take any dose or by mistake miss a dose, take it as soon as you remember it. If it is already the time for the next dose, skip the forgotten dose. Take your next medicine at the regular time schedule. Do not double the dose.
  • Storage:

  • The medicine should not come in direct contact with heat, air, light and may damage your medicines. Exposure to medicine might cause some harmful effects or serious side effects. The medicine must be kept in a safe place and out of children’s reach.
  • Zonisamide vs Lacosamide :

    Zonisamide is a medication that is used in conjunction with other medications to help control partial seizures. Lacosamide is a medication used to treat partial-onset seizures and diabetic neuropathic pain as an adjunctive treatment.
    It is available in form of a pill only. It is available in three forms - pill, liquid, injection
    Zonisamide has been shown to be safe and effective against a wide range of epilepsy and seizure types, including partial and generalized seizures. Lacosamide is only effective for partial seizures. It is not effective in treating other types of seizures.

    Frequently Asked Questions:

    Zonisamide is a medication that is used in conjunction with other medications to treat certain types of seizures. It belongs to anticonvulsant medication class.
    Zonisamide in bipolar disorder has shown results for efficacy in both the manic and depressed phases of the illness. In addition to its putative mood-stabilizing properties, zonisamide has been shown to have positive effects on weight and metabolic parameters.
    Some of the most common side effects of zonisamide capsules are drowsiness, tiredness, loss of appetite, can make you sleepy.
    Inhibiting carbonic anhydrase reduces apnoeic events in sleep-disordered breathing. In obese patients, zonisamide inhibits carbonic anhydrase and causes weight loss. This study looked at the relative impact of these two properties, which may both help with obstructive sleep apnea.
    Some people may become agitated, irritable, or exhibit other abnormal behaviors. It may also lead to suicidal thoughts and tendencies in some people, as well as an increase in depression.
    Zonisamide primarily impaired spatial memory in a high acute dose, but its effect was only observed in the initial phase of the study when administered repeatedly. Only after repeated zonisamide administration were emotional memory disturbances observed.
    Zonisamide is a potentially effective migraine prevention medication. Topiramate is the first-line drug for migraine prevention, and it is also effective in patients who have failed other medications or who have chronic migraines.


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