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By Medicover Hospitals / 11 Jan 2021
Home | Medicine | Omeprazole

What is Omeprazole?

Omeprazole is a drug used in the treatment of gastroesophageal reflux disorder, peptic ulcer disease, and Zollinger-Ellison syndrome, marketed under the brand names Prilosec and Losec, among others. It is also used in people at high risk for the prevention of upper gastrointestinal bleeding.

  1. Omeprazole Uses
  2. Omeprazole Side effects
  3. Omeprazole Precautions
  4. Omeprazole Interactions
  5. Omeprazole Storage
  6. Omeprazole vs Rabeprazole
  7. Frequently Asked Questions
  8. Citations

Omeprazole Uses:

  • Omeprazole is used to treat some problems with the stomach and esophagus (such as acid reflux, ulcers). It works by reducing the quantity of acid that your stomach produces. Symptoms such as heartburn, difficulty swallowing, and constant coughing are alleviated. This medication helps to cure acid damage in the stomach and the esophagus helps prevent ulcers and may help prevent esophageal cancer. Omeprazole belongs to a family of drugs called inhibitors of the proton pump (PPIs).
  • Over-the-counter omeprazole drugs are used to treat chronic heartburn if you are self-treated with this drug (occurring 2 or more days a week). Since it can take 1 to 4 days to have full effect
  • For over-the-counter items, read the package instructions carefully to ensure that the product is correct for you. Even if you have used the product before, check the ingredients on the bottle. The ingredients may have been modified by the manufacturer. Also, products with similar brand names might contain different ingredients intended for different purposes. You could be harmed by taking the wrong thing.

How to use

  • If you have been prescribed this drug by your doctor, read your pharmacist's Patient Information Leaflet, if available, before you start taking omeprazole and any time you receive a refill. Before taking this drug, read and follow all instructions on the product label if you are taking the over-the-counter product for self-treatment.
  • Take this medication by mouth, usually once a day before a meal, as directed. The dosage and duration of therapy totally depend on your medical condition and treatment reaction. In infants, the dose is often weight-based. Do not raise your dosage or take this medicine more often than prescribed.
  • Do not smash or crack delayed-release capsules, or chew them.
  • Using dry hands to treat the tablets while you are using the disintegrating delayed-release tablets. On your tongue, but the tablet and let it dissolve. It can be swallowed with or without water after the tablet has dissolved. With water, the tablets can also be swallowed whole.
  • Antacids should be taken along with this medication if needed. If sucralfate is still used, take omeprazole at least 30 minutes before taking sucralfate.
  • To get the most benefits from it, use this drug as advised. And if you are feeling better, continue taking this drug for the recommended period of treatment. If the over-the-counter medication is self-treated, do not take it for more than 14 days unless instructed by your doctor.
  • If the condition persists or gets worse, tell your doctor. Inform your doctor if your heartburn lasts for more than 14 days, or if you need to take this drug more than once every 4 months if you are self-treated. Over time, the probability of side effects goes up. Tell your doctor how long you need this drug to take.

Omeprazole Side Effects:

  • There may be headaches or stomach pain. Tell your physician or pharmacist immediately if any of these symptoms continue.
  • If you have been directed to use this product by your doctor, note that he or she has found that the advantage is greater than the risk of side effects.
  • If you notice some severe side effects, including symptoms of low blood levels of magnesium (such as excessively fast/slow/irregular pulse, persistent muscle spasms, seizures), signs of lupus, notify your doctor immediately (such as a rash on the nose and cheeks, new or worsening joint pain).
  • Due to a bacteria named C, this drug will rarely cause a serious intestinal disorder. Challenging. This condition can occur during therapy or weeks to months after discontinuation of treatment. If you get diarrhea that doesn't end, abdominal or stomach pain/cramping, fever, blood/mucus in your stool, tell your doctor right away.
  • Do not use anti-diarrhea or opioid medications if you have these symptoms, since they can make the symptoms worse.
  • In rare cases, vitamin B-12 deficiency has been caused by proton pump inhibitors (like omeprazole). If they are taken every day for a long time, the danger is greater (3 years or longer). If you develop any signs of vitamin B-12 deficiency, tell your doctor right away.
  • It is very unusual to experience a very severe allergic reaction to this drug. However, if you experience any symptoms of a serious allergic reaction, including rash, itching/swelling (especially of the face/tongue/throat), extreme dizziness, difficulty breathing, signs of kidney problems, get medical attention right away (such as a change in the amount of urine).


  • Tell your doctor or pharmacist whether you are allergic to it or to related medicines (such as esomeprazole, lansoprazole, pantoprazole) before taking omeprazole or if you have any other allergies. There possibly might be some inactive ingredients in this substance that may cause allergic reactions or other problems. For more details, talk to your pharmacist.
  • Inform your doctor or pharmacist of your medical history, particularly of liver disease, lupus, before taking this drug.
  • Signs of a more severe condition may simply be some symptoms. If you have heartburn and lightheadedness/sweating/dizziness, chest/jaw/arm/shoulder pain, get medical attention right away (especially with shortness of breath, unusual sweating)
  • In addition, if you have any of these symptoms of a serious condition before you self-treat with this drug, get medical attention right away: trouble/pain swallowing food, bleeding vomit, vomit that looks like coffee grounds, bloody/black stools, heartburn for over 3 months, constant chest pain, frequent wheezing (especially with heartburn), nausea/vomiting, pain in the stomach.
  • Inform your doctor of all the medications you need before having surgery (including prescription drugs, nonprescription drugs).
  • Your risk of bone fractures can be increased by proton pump inhibitors (such as omeprazole), particularly with longer usage, higher doses, and in older adults. Speak to your doctor or pharmacist about ways to stop bone loss/fracture, such as taking vitamin D supplements and calcium (such as calcium citrate).
  • Older adults may be more prone to this drug's side effects, especially bone loss and fractures (see above), and C. Challenging infection (see Side Effects section).
  • Children may be more prone to this drug's side effects, especially fever, cough, and nose/throat/airway infections.
  • This drug should be used when you are pregnant only when it is obviously needed. Discuss with your doctor the risks and advantages.
  • It moves into breast milk with this drug. The results are unclear on a breastfeeding child. Before breastfeeding, consult the doctor.


  • Drug interactions might affect the working of your drugs or raise the risk of serious side effects. Without your doctor's permission, do not adjust the dosage of any medication.
  • Cilostazol, clopidogrel, methotrexate (especially high-dose treatment), rifampin, St John's wort, are some of the items that can interfere with this medication.
  • Some drugs require gastric acid so that they can be fully absorbed by the body. Omeprazole reduces the amount of acid in the stomach, so how well these drugs perform will change. Atazanavir, erlotinib, nelfinavir, pazopanib, rilpivirine, some azole antifungals (itraconazole, ketoconazole, posaconazole), among others, are some affected drugs.
  • Omeprazole, like esomeprazole, is somewhat similar. Do not use any esomeprazole-containing drug when taking omeprazole.
  • Some laboratory tests can interfere with this drug, likely causing false reports in the test results.

Important information

  • Omeprazole is not intended to alleviate the effects of heartburn immediately.
  • Heartburn is often mistaken for the first signs of a heart attack. If you have chest pain or a heavy feeling, pain extending to your arm or shoulder, nausea, sweating, and a general sick feeling, seek emergency medical treatment.
  • Omeprazole can cause problems with the kidneys. If you urinate less than normal or if you have blood in your urine, tell your doctor.
  • A symptom of a new infection may be diarrhea. If you have diarrhea that is watery or that has blood in it, call the doctor.
  • Omeprazole can cause symptoms of lupus that are new or worsening. If you have joint pain and a skin rash on your cheeks or arms that gets worse in the sunshine, tell your doctor.
  • You could be more likely to get a broken bone in the long term or more than once a day while taking omeprazole.
  • It is appropriate to take Prilosec OTC (over-the-counter) for no more than 14 days in a row. Before you start another 14-day treatment, allow at least 4 months to pass.


If this drug has been prescribed for you by your doctor, do not discuss it with anyone. If your doctor instructs you to take this drug on a daily basis for a long period of time, laboratory and medical tests (such as a blood test for magnesium, vitamin B-12 levels) can be conducted on a regular basis to monitor your progress or to check for side effects. Keep all medical and laboratory appointments set.

Missed Dose:

If you forget a dose, take it as soon as you recall it. If the time for the next dose is close, skip the skipped dose. At your normal time, take your next dose.


Store it away from heat and moisture at room temperature. Do not store in the bathroom. Do not flush this in drainage and sink

Omeprazole vs Rabeprazole :

Omeprazole decreases stomach acid production Prescribed for Erosive Esophagitis
Proton pump inhibitors Proton pump inhibitors
Dosage Form(s) Available are
  • Oral delayed release tablet
  • Oral delayed release capsule
Oral delayed release tablet
Brand Names
  • Omesec, Prilosec, Prilosec OTC
Brand Names
  • Aciphex, Aciphex Sprinkle
1.5 hours 2 hours

Frequently Asked Questions:

The amount of acid your stomach makes is reduced by Omeprazole. It is commonly used for indigestion, heartburn, and acid reflux therapy. It is sometimes used to avoid stomach ulcers and to treat them. For a rare condition caused by a tumor in the pancreas or gut called Zollinger-Ellison syndrome, omeprazole is also taken.
Side effects are:-
  • Pain in the back, leg, or stomach.
  • Crusting or bleeding sores on the lips.
  • Blisters
  • Continuous mouth ulcers or sores.
  • Difficult, burning, or painful urination.
  • An overall sense of pain or disease.
  • Pruritus, skin rash.
  • Aches or cramps in the muscles.
Before a meal, take capsules of omeprazole or delayed-release capsules, preferably in the morning. It is possible to take Omeprazole tablets with food or on an empty stomach. At least 1 hour before the meal, take omeprazole powder for oral suspension on an empty stomach.
The use of proton pump inhibitors (PPI), especially omeprazole, has been linked to the development of chronic kidney disease in recent years (CKD). Worldwide, these medications are widely used. The correlation between the use of PPI and the initiation of acute renal failure and CKD has been identified in several studies.


  • Omeprazole,
  • Omeprazole for treatment,