Methotrexate is one of the most effective drugs for treating inflammatory forms of arthritis and is widely used. Despite the misconception that methotrexate is extremely toxic, it is one of the best arthritis medications.
Methotrexate interferes with the production of certain body cells, especially rapidly reproducing cells such as cancer cells, bone marrow cells, and skin cells.
What are the Uses of Methotrexate Tablets?
This medicine is prescribed for managing severe diseases that don't respond well to other treatments.
Cancers related to abnormal pregnancy tissue (gestational trophoblastic diseases)
Secondary Uses of Methotrexate
Often used along with physical therapy
May be combined with other medications for better results in autoimmune disorders
How Does Methotrexate Tablet Work (Mechanism of Action)?
Methotrexate targets rapidly dividing cells and slow the immune response to reduce inflammation and stop abnormal cell growth.
It blocks the enzyme dihydrofolate reductase, which is needed for DNA synthesis in fast-growing cells.
In autoimmune conditions, it helps reduce immune system activity that causes inflammation.
In cancer, it'slows or stops the growth of harmful cells.
Dosage Instructions of Methotrexate
Methotrexate is available in multiple dosage forms to accommodate various medical conditions and patient needs, ranging from oral tablets to injectable solutions.
Talk to your doctor if you experience serious side effects such as mouth sores, diarrhea, signs of anemia, signs of liver problems, easy bruising, and swollen lymph nodes.
Precautions Before Using Methotrexate
Some people should avoid this medication, and others should take extra care while using it.
Who should avoid this medicine?
Pregnancy: Methotrexate can cause embryo-fetal toxicity and fetal death. It should not be used during pregnancy.
Breastfeeding: Methotrexate can pass into breast milk and may cause serious side effects in infants.
Use with caution if you have:
Liver or kidney problems
A weakened immune system
Blood cell disorders
Stomach or intestinal issues
Are There Any Age Restrictions for Using Methotrexate?
Safe use in children is limited to certain conditions like juvenile arthritis.
Elderly patients may be more sensitive to side effects.
Alcohol or Food Interactions
Avoid alcohol as it increases the risk of liver damage
Maintain good hydration and nutrition as advised by your doctor
Possible Drug Interactions with Methotrexate
Let your doctor know about all medications you take to avoid dangerous interactions.
Methotrexate may interact with:
NSAIDs (like ibuprofen or aspirin)
Antibiotics (such as penicillin)
Other cancer drugs:
Seizure medications
Vitamins, especially folic acid (your doctor may adjust this)
Herbal products and supplements may also interfere with methotrexate's effects
How Should Methotrexate Be Stored?
Proper storage ensures the medicine remains safe and effective.
Store at room temperature (20°C to 25°C or 68°F to 77°F)
Keep it away from direct sunlight, moisture, heat, children and pets.
Methotrexate vs Folic Acid
Methotrexate
Folic Acid
One of the most effective drugs for treating inflammatory forms of arthritis.
The synthetic source of folate, a naturally occurring B vitamin.
Used for treating severe psoriasis and various cancers.
Used to prevent and treat low folate levels and high homocysteine levels in the blood.
Yes, Methotrexate is classified as a chemotherapy drug in high doses for cancer, but at lower doses, it's used to treat autoimmune diseases like RA and psoriasis.
Yes, it is recommended to drink plenty of water (about 8 cups or 2 liters) on the day you take methotrexate. This helps maintain hydration and support kidney function.
Some studies suggest that methotrexate may cause slight weight gain in individuals with rheumatoid arthritis over a period of several months. However, weight changes can vary among individuals.
Methotrexate usually takes 4 to 6 weeks to show improvement in symptoms. In some cases, it may take up to 12 weeks for full benefits to be felt.
Methotrexate is taken once a week because it is an antifolate medication that works by inhibiting the metabolism of folic acid. This schedule is effective in treating conditions like rheumatoid arthritis, severe psoriasis, and inflammatory bowel disease.
Methotrexate tablets should be stored at room temperature. If using injection form, follow your doctor's instructions-it may or may not need refrigeration.
Methotrexate is a traditional drug that reduces immune activity, while Humira is a biologic that targets specific inflammation proteins. They may be used together.
Yes, Methotrexate can cause mild hair thinning in some people. It's usually temporary and improves once the dosage is adjusted or stopped.
A 20mg dose of methotrexate is considered moderate to high, depending on the condition being treated. It’s commonly used in autoimmune diseases like rheumatoid arthritis but always under medical supervision.
Disclaimer: The information provided is accurate and up-to-date to the best of our knowledge. However, it should not be considered a substitute for medical advice or consultation. We do not guarantee its completeness or accuracy. The absence of specific warnings does not mean a medicine is safe for all users. We are not responsible for any outcomes based on this information and strongly recommend consulting a doctor for any medical concerns or questions.
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