Seroquel, also known by its generic name quetiapine, is an atypical antipsychotic medication commonly prescribed for psychiatric conditions. It is widely used to manage symptoms of schizophrenia, bipolar disorder, and major depressive disorder (MDD). Seroquel helps restore the balance of neurotransmitters in the brain, leading to improved mood, cognition, and behavior.

What Are the Uses of Seroquel(Quetiapine) Tablet?

Seroquel is effective in managing psychotic and mood disorders. It helps reduce symptoms such as hallucinations, mood swings, anxiety, and sleep disturbances, and is also used off-label for certain other psychiatric conditions.

Conditions Seroquel is Used to Treat

  • Schizophrenia (adults and adolescents aged 13+)
  • Bipolar disorder, including:
    • Manic episodes
    • Depression
    • Long-term mood stabilization
  • Major Depressive Disorder (as an adjunct therapy to antidepressants)

Secondary Benefits of Seroquel Tablet

  • Generalized anxiety disorder (off-label)
  • Sleep disorders (off-label and under careful supervision)
  • PTSD and other mood-related conditions (off-label)

Seroquel may:

  • Reduce hallucinations and delusions
  • Stabilize mood swings
  • Improve concentration, mood, Enhance sleep, and appetite
  • Lessen anxiety and agitation

How Does Seroquel Tablet Work?

Seroquel targets dopamine and serotonin receptors in the brain to regulate neurotransmitter levels. This mechanism stabilizes mood and perception and helps manage psychiatric symptoms.

Seroquel works by:

  • Blocking dopamine (D2) and serotonin (5-HT2) receptors in the brain
  • Modifying levels of norepinephrine, histamine, and other neurotransmitters

These actions help balance brain chemicals involved in mood, thinking, and perception. It does not directly affect hormones but can influence hormone levels over time (e.g., prolactin).

Dosage

Seroquel is available as immediate and extended-release tablets, taken once to three times daily. Dosage starts low and is adjusted gradually under medical supervision for safety and effectiveness.

Typical Dosage Instructions

  • Form: Oral tablets (immediate and extended-release)
  • Frequency: 1-3 times daily depending on condition and formulation
  • Start Low, Go Slow: Initial doses are gradually increased under doctor supervision

Always follow the exact dosage as prescribed by your healthcare provider.

What Should I Do If I Miss a Dose of Seroquel?

If a dose is missed, take it as soon as remembered unless it's close to the next dose. Never double the dose to compensate resume your regular schedule.

  • Take the missed dose as soon as you remember
  • If it's close to the next dose, skip the missed one
  • Do not double the dose to catch up

What Happens If There's an Overdose?

An overdose of Seroquel can cause extreme sedation, low blood pressure, irregular heartbeat, or seizures. Immediate medical attention is necessary if an overdose is suspected.

Symptoms of Overdose

  • Extreme drowsiness or sedation
  • Rapid heartbeat
  • Low blood pressure
  • Breathing difficulties
  • Seizures
  • Loss of consciousness

Seek immediate emergency care in case of overdose.

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What Are the Side Effects of Seroquel?

Common side effects of Seroquel include drowsiness, dry mouth, and weight gain. More serious but rare effects may involve heart rhythm problems, suicidal thoughts, or movement disorders.

Common Side Effects

  • Drowsiness or fatigue
  • Dizziness, lightheadedness
  • Dry mouth, sore throat
  • Weight gain, increased appetite
  • Constipation, upset stomach
  • Headache, mood changes
  • Breast swelling or discharge
  • Menstrual irregularities

Serious but Rare Side Effects

  • Suicidal thoughts or behavior
  • Heart rhythm issues (QT prolongation)
  • Neuroleptic malignant syndrome (NMS)
  • Seizures
  • Uncontrolled movements (tardive dyskinesia)

Consult your doctor if any side effects worsen or if you notice unusual symptoms.

Precautions and Warnings

Caution is needed in individuals with heart, liver, thyroid, or seizure conditions. Pregnant women and the elderly should use Seroquel only under strict medical guidance due to potential risks.

Who Should Avoid Seroquel?

  • Individuals with allergies to quetiapine
  • Pregnant or breastfeeding women (use only if benefits outweigh risks)
  • People with a history of heart conditions or stroke

Conditions Where Caution is Needed

  • Liver problems
  • Diabetes or blood sugar disorders
  • Seizure history
  • Thyroid issues
  • Eye problems (e.g., cataracts)

Are There Any Age Restrictions for Using Seroquel?

Seroquel is approved for use in teens and children for specific conditions, but not for those under 10.Older adults may be more sensitive to side effects such as dizziness or sedation.

  • Approved for:
    • Schizophrenia: 13 years and older
    • Bipolar disorder: 10 years and older
  • Not typically recommended for children under 10
  • Elderly patients may be at higher risk for side effects like dizziness or sedation

Alcohol or Food Interactions

Alcohol should be avoided while taking Seroquel, as it increases the risk of drowsiness. The medication can be taken with or without food, though food may help reduce nausea.

  • Avoid alcohol - increases risk of severe drowsiness or dizziness
  • May be taken with or without food, though food can help reduce stomach upset

Possible Interactions with Other Medications (Drug Interactions)

Seroquel may interact with drugs like antifungals, antibiotics, and seizure medications. These interactions can affect the drug's effectiveness or increase side effect risks.

Seroquel may interact with:

  • QT-prolonging drugs (e.g., amiodarone, moxifloxacin)
  • Antifungals (e.g., ketoconazole, itraconazole)
  • Antibiotics (e.g., rifampin)
  • Seizure medications (e.g., phenytoin, carbamazepine)
  • Antidepressants, antihistamines, and sleep aids

Supplements and Herbal Interactions

  • St. John's Wort may reduce Seroquel's effectiveness
  • Caution with other CNS depressants

Always inform your doctor about all medications and supplements you're taking.

How Should Seroquel Be Stored?

Recommended Storage Temperature

  • Store at room temperature (20°C to 25°C / 68°F to 77°F)
  • Keep in a dry place, away from light and heat

What Happens If Seroquel Is Not Stored Properly?

  • Exposure to moisture or heat may reduce effectiveness
  • Degraded medication may pose safety risks

Important Storage Tips

  • Keep out of reach of children
  • Do not store in bathrooms or humid places
  • Dispose of expired or unused medication'safely

References

In Brief: Absorica for Acne | Acne | JAMA | JAMA Network
Seroquel (Quetiapine) Prescribing Information | FDA | Accessdata
Quetiapine Oral Route | Drug Information | Mayo Clinic
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Frequently Asked Questions

This medicine is used to treat a number of psychiatric and mood disorders (such as schizophrenia, bipolar disorder, sudden episodes of mania, or depression associated with bipolar disorder). Seroquel is an antipsychotic medicine (atypical type).

The Food and Drug Administration (FDA) has not approved Seroquel for the treatment of insomnia. It is, however, often administered off-label as a short-term sleep aid due to its sedative effects.

Seroquel is an antipsychotic drug used to treat schizophrenia in adults and children aged 13 and up. Seroquel is an antipsychotic drug used to treat bipolar disorder (manic depression) in adults and children aged 10 and up. Seroquel is also used to manage major depressive disorder in adults when paired with antidepressant medication.

Two recent studies indicate that the antipsychotic medication Seroquel can aid in the treatment of major depression and generalized anxiety disorder. Seroquel has also obtained FDA approval for the treatment of schizophrenia and bipolar disorder (formerly called manic-depressive illness).

Seroquel is a second-generation antipsychotic that also activates the H1 and 2A histamine receptors. Its sedative effects are believed to be due to this, which is why it's used off-label for insomnia.

One of the most common side effects of Seroquel (generic name Seroquel) is that it makes people sleepy. Many physicians prescribe it as a sleeping pill for this purpose, and sometimes at the same dosage as you do — 50 mg.

Seroquel, like other related drugs, can raise the risk of suicidal thoughts or actions in young adults, with the risk being greater in those under the age of 25. Seroquel’s extended-release should not be granted to those under the age of eighteen.

Seroquel is a schizophrenia drug that acts in the brain. It's also known as an atypical antipsychotic or a second-generation antipsychotic (SGA). Seroquel enhances thought, mood, and actions by rebalancing dopamine and serotonin.

The evidence for Seroquel qualifies it as a bimodal mood stabilizer based on its proven efficacy in the treatment of bipolar mania and depression, according to a liberal concept.

Insomnia is treated with Seroquel (quetiapine) and Ambien (zolpidem). Ambien is primarily used to treat insomnia, while Seroquel is used to treat insomnia off-label.


Disclaimer: The information provided is accurate and up-to-date to the best of our knowledge. However, it should not be considered a substitute for medical advice or consultation. We do not guarantee its completeness or accuracy. The absence of specific warnings does not mean a medicine is safe for all users. We are not responsible for any outcomes based on this information and strongly recommend consulting a doctor for any medical concerns or questions.

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