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By Medicover Hospitals / 16 Feb 2021
Home | Medicine | Selegiline
  • Selegiline is a monoamine oxidase type B inhibitor which is prescribed by the doctors for the management of the symptoms of Parkinson’s diseases in patients. It can slow clinical disease progression and postpone the need for treatment with levodopa. It can also be treated with levodopa upon impairment onset. Selegiline is available under the following brand name called Eldepryl and Zelapar. The medication prevents the breakdown of a chemical in the brain called dopamine.
    1. Selegiline Uses
    2. Side effects
    3. Precautions
    4. Dosage
    5. Storage
    6. Selegiline vs Adderall
    7. FAQ's

    Selegiline Uses:

  • This drug is used to treat Parkinson's disease-induced movement disorders. It does not cure Parkinson's disease, but it may improve shakiness (tremor), muscle weakness, loss of normal movement when the dosage of other Parkinson's medicines wears off (failure at the end of the dose), and sudden change between normal movement and stiffness ("on-off" problems). The range of movement and the ability to walk, dress, and exercise can be enhanced. Selegiline is typically used in conjunction with other drugs (e.g., carbidopa, levodopa). Selegiline is an enzyme blocker (inhibitor of MAO) that works by slowing down the brain's degradation of certain natural substances.
  • Trazodone Side Effects:

  • Some of the common side effects of Selegiline are:
    • Dizziness
    • Lightheadedness
    • Fainting
    • Dry mouth
    • Nausea
    • Vomiting
    • Stomach pain
    • Difficulty in swallowing
    • Heartburn
    • Gas
    • Constipation
    • Sleepiness
    • Depression
    • Muscle pain
    • Weakness
    • Rash
  • Some of the serious side effects of Selegiline are:
    • Severe Headache
    • Chest pain
    • Fast and irregular heartbeat
    • Sweating
    • Nausea and Vomiting
    • Hallucinations
    • Hypertension
    • Urinary retention
  • If you have any of these serious symptoms immediately contact your doctor for further assistance. In any case, due to Selegiline if you get any kind of reactions in your body try avoiding it.
  • A doctor advised you to take the medicines by seeing your problems and the benefits of this medicine are greater than the side effects. Majority of the people who use this medicine don’t show any side effects. Get medical help immediately if you get any serious Selegiline side effects.
  • Precautions:

  • Before taking Selegiline, talk with the doctor if you are allergic to it or any medications. The product may contain some inactive ingredients which can cause some serious allergic reactions or some other serious problems.
  • Before using the Selegiline talk with the doctor if you are having any medical history such as:
    • Adrenal gland tumour
    • Cerebrovascular Disease
    • Heart Problems
    • Bleeding problems
    • Headaches
    • Peptic Ulcer

    How to take Selegiline?

  • Selegiline comes in the form of Capsule and as an orally dissolving tablet. Usually, the capsule is taken twice a day for breakfast and lunch. Without food, water, or other liquids, the orally disintegrating tablet is typically taken once a day before breakfast. Take Selegiline as prescribed. You can experience a sudden and dangerous rise in blood pressure if you take too much selegiline. Do not remove the blister that holds the tablets from the outer pouch until you are ready to take a dose if you are taking the orally disintegrating tablet. On the tongue, but the tablet and wait for it to dissolve. Do not swallow the tablet. For 5 minutes before you take the tablet, and for 5 minutes after you take the tablet, do not eat or drink anything. The doctor can start you on a low dose of selegiline and raise your dose after six weeks if you are taking an orally disintegrating tablet.
  • Dosages of Selegiline

  • Oral tablet: Imipramine
    • Recommended dose: 5 mg twice daily orally.
    • Maximum dose: 10 mg per day by mouth.
  • Oral disintegrating tablet:
    • Original dose: 1.25 mg orally for at least 6 weeks once a day. After 6 weeks, if necessary, the dose can be increased to 2.5 mg orally once a day.
    • Maintenance dose: oral administration of 1.25 to 2.5 mg once a day
    • Total dose: 2.5 mg once daily, orally.

    Missed Dose:

  • Missing one or two-dose of Selegiline won’t show any effect on your body. The skipped dose causes no problem. But with some medication, it won’t work if you don’t take the dosage on time. If you miss a dose some sudden chemical change may affect your body. In some cases, your doctor would advise you to take the prescribed medicine as soon as possible if you have missed the dose.
  • Overdose:

  • Overdose of a drug can be accidental. If you have taken more than the prescribed Selegiline tablets there is a chance of getting a harmful effect on your body’s functions. Overdose of a medicine can lead to some medical emergency.
  • Interactions

  • Selegiline interactions can affect the working of the drugs or can increase the risk of serious side effects. Maintain a track of all the drugs you use (including prescription/nonprescription medicines and herbal products) and share it with your doctor and pharmacist. Without being treated by your doctor, do not start, stop, or adjust the dose of any medicine.
  • Some of the drugs that selegiline can interact with include: antidepressants (including bupropion, maprotiline, mirtazapine), other MAO inhibitors (including isocarboxazid, linezolid, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, safinamide, tranylcypromine), appetite suppressants (including diethylpropion), attention deficit disorder medicines (including atomoxetine, methylphenidate), apraclonidine.
  • Storage

  • Direct contact with heat, air and light may damage your medicines. The exposure of medicine may cause some harmful effects. The medicine must be kept in a safe place and out of children’s reach.
  • Mainly the drug should be kept at room temperature between 68ºF and 77ºF (20ºC and 25ºC).
  • Before taking Selegiline consult your Doctor. In case if you face any problems or get any side effects after taking Selegiline rush immediately to your nearby hospital or consult your doctor for better treatment. Carry your medications always in your bag while travelling to avoid any immediate emergencies. Follow your prescription and follow your Doctor advice whenever you take Selegiline.
  • Selegiline vs Adderall:

    Selegiline is a monoamine oxidase type B inhibitor which is prescribed by the doctors for the management of the symptoms of Parkinson’s diseases in patients. Adderall is a prescription drug containing two medicines: dextroamphetamine and amphetamine. It belongs to a class of drugs known as stimulants.
    Selegiline is used to treat Parkinson's disease-induced movement disorders. This combination drug is used for the treatment of ADHD, and attention deficit hyperactivity disorder.
    Some of the common side effects of Selegiline are:
    • -Dizziness
    • -Lightheadedness
    • -Fainting
    • -Dry mouth
    • -Nausea
    Some of the common side effects of Selegiline are:
    • -Palpitations
    • -Tachycardia
    • -Euphoria
    • -Blurred vision
    • -Dryness of mouth

    Frequently Asked Questions:

    Selegiline is used in people taking the combination of levodopa and carbidopa to help control the symptoms of Parkinson's disease (A nervous system condition that causes problems with coordination, muscle control, and balance).
    Selegiline, rasagiline, and safinamide are particular inhibitors of MAO, meaning that dietary changes or restrictions are not necessary. Dopamine agonists act by activating the brain's dopamine receptors directly.
    As its potential for abuse has been reported to be very low, Selegiline can be an interesting alternative to the more classical stimulants. Special note must be made of the fact that this compound is often considered a basic monoamine oxidase B inhibitor rather than an amphetamine precursor.
    Selegiline is used to better treat Parkinson's disease symptoms by increasing the amount of dopamine in the brain. In people with Parkinson's, dopamine is a naturally occurring substance that is required to regulate movement and its levels are decreased.
    Selegiline is the only canine cognitive disorder medication approved by the FDA. Although the onset of action can be variable (between four and 12 weeks), after one month of treatment, most dogs display some improvement and there may be a continued improvement over time.


  • Selegiline,
  • Pharmacology of selegiline,