Selegiline is a medication commonly used to treat symptoms of Parkinsons disease and major depressive disorder. It works by helping to increase levels of certain natural substances in the brain that affect mood and movement.
Selegiline belongs to a class of drugs called monoamine oxidase inhibitors (MAOIs), specifically MAO-B inhibitors. It may be prescribed alone or with other medications. Available in tablet and patch forms, it is essential to use Selegiline under medical supervision due to possible side effects and interactions.
What Is Selegiline?
Selegiline is a monoamine oxidase type B (MAO-B) inhibitor used to manage symptoms of Parkinson's disease. It helps by preventing the breakdown of dopamine in the brain, which is crucial for controlling movement.
Major depressive disorder (in transdermal patch form)
Secondary Uses of Selegiline
Off-label use in Alzheimer's disease (to improve mental function)
Used in some cases for narcolepsy
How Does Selegiline Work?
Selegiline tablet works by blocking the enzyme monoamine oxidase B (MAO-B) in the brain. This enzyme normally breaks down dopamine, a chemical that helps control movement and emotions. By inhibiting MAO-B, selegiline increases dopamine levels, improving mood and movement control. It does not directly affect hormones but influences brain chemistry through the nervous system.
Selegiline Dosage
Typical Dosage Instructions (As Per Doctor's Advice): The dosage of Selegiline varies based on the condition being treated. For Parkinson's disease, the usual oral dose is 5 mg taken twice a day, preferably during breakfast and lunch. For depression (transdermal patch), your doctor will recommend the right patch strength and how often it'should be changed. Always follow your doctor's prescription strictly.
What Should I Do If I Miss a Dose?
If you miss a dose of Selegiline, take it as soon as you remember. However, if it's close to your next dose, skip the missed one and continue with your regular schedule. Do not double the dose to make up for the missed one.
What Happens If an Overdose?
An overdose of Selegiline may cause serious symptoms such as severe headache, dizziness, irregular heartbeat, high blood pressure, confusion, or even fainting. In case of suspected overdose, seek immediate medical attention or contact a poison control centre.
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When you take a Selegiline tablet, it changes the levels of certain brain chemicals like dopamine. While this helps with conditions like Parkinson's disease or depression, it may also affect other systems in your body. These changes can sometimes cause unwanted side effects, especially if taken with certain foods, alcohol, or other medications.
Note: Always consult your doctor if any side effects worsen or feel unusual.
Precautions and Warnings
Who Should Avoid This Medicine?
Pregnant or breastfeeding women, unless advised by a doctor
Children, unless specifically prescribed
People with a known allergy to Selegiline or similar drugs
Conditions Where Caution Is Needed
Liver disease
Kidney problems
Heart conditions or high blood pressure
Mental health issues like schizophrenia or bipolar disorder
Thyroid disorders
Are There Any Age Restrictions for Using Selegiline?
Generally not recommended for children under 18 years
Elderly patients may require lower doses and close monitoring
Possible Interactions with Other Medications (Drug Interactions)
Selegiline may interact with antidepressants (especially SSRIs, SNRIs, and tricyclics), opioids, and certain cough medications. These interactions can increase the risk of serious side effects such as serotonin syndrome or high blood pressure crises.
Possible Impact When Combined with Supplements or Herbal Products
Combining Selegiline with herbal supplements like St.John's Wort or ginseng may increase the risk of nervous system stimulation or serotonin-related side effects. Always consult your doctor before taking any herbal remedies while on Selegiline.
How Should Selegiline Be Stored?
Recommended Storage Temperature for Selegiline: Store Selegiline at room temperature, typically between 20°C and 25°C (68°F and 77°F), away from heat, moisture, and direct sunlight.
What Happens If Selegiline Is Not Stored Properly?
Improper storage can reduce the drugs effectiveness. Exposure to extreme heat, cold, or humidity may compromise the effectiveness of the medicine, leading to reduced symptom control or therapeutic failure.
Selegiline is used in people taking the combination of levodopa and carbidopa to help control the symptoms of Parkinson's disease.
No, selegiline is not a dopamine agonist. It is a selective monoamine oxidase B (MAO-B) inhibitor.
No, selegiline is not considered a stimulant. Its potential for abuse is very low.
Selegiline is prescribed for Parkinson's disease to increase dopamine levels in the brain, which helps to better control movement and other symptoms.
The onset of action of selegiline can vary, typically showing improvement in Parkinson's symptoms within several weeks to months of starting treatment
Disclaimer: The information provided is accurate and up-to-date to the best of our knowledge. However, it should not be considered a substitute for medical advice or consultation. We do not guarantee its completeness or accuracy. The absence of specific warnings does not mean a medicine is safe for all users. We are not responsible for any outcomes based on this information and strongly recommend consulting a doctor for any medical concerns or questions.
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