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By Medicover Hospitals / 10 March 2021
Home | Medicine | Savella

What is Savella?

  • Savella is a prescription medicine used to treat fibromyalgia. For the treatment of fibromyalgia, Savella (milnacipran) is the first-choice medication. You can take Savella (milnacipran) with or without food. You must take it according to a strict schedule, which can be perplexing in the first month.
    1. Savella Uses
    2. Savella Side effects
    3. Precautions
    4. Interactions
    5. Dosage
    6. Storage
    7. Savella vs Cymbalta
    8. Frequently Asked Questions
    9. Citations

    Savella Uses

  • It is used to treat pain caused by a condition called fibromyalgia that affects muscles, tendons, ligaments, and tissue support. This medicine is a serotonin-norepinephrine reuptake inhibitor (SNRI) that works by helping to restore the balance of certain natural substances in the brain (neurotransmitters).
  • How to use savella

  • Read your pharmacist's Medication Guide before you start using milnacipran and every time you get a refill. Consult your doctor.
  • Take this medicine orally with or without food, usually 2 times a day or as directed by your doctor. If you have nausea, it may help you to take this medicine with your food.
  • The dosage is based on your health condition, medical history, and response to your treatment.
  • Your doctor may prescribe you a low dose to reduce your risk of side effects and gradually will increase your dose.
  • If you suddenly stop using this medicine, you might have symptoms of withdrawal (such as mood swings, headache, tiredness, sleep changes, brief feelings similar to electric shock). Your doctor might lower your dosages slowly to help prevent withdrawal. Withdrawal is more likely if you have been using milnacipran for a long time or at high doses.
  • Savella Side Effects:

    • Nausea
    • Headache
    • Constipation
    • Drowsiness
    • Tiredness
    • Weakness
    • Dizziness
    • Trouble sleeping
    • Hot flush
    • Increased sweating
    • Vomiting
    • Irregular heartbeat (palpitations)
    • Heart rate increased
    • Dry mouth
    • High blood pressure
    • Hypertension
    • Irritation
    • Rashes
    • Vomit
    • Lightheadedness


  • Tell your doctor if you are allergic to savella (milnacipran), or to levomilnacipran, or if you have any other allergies before taking milnacipran. This product might have some inactive ingredients or substances that might cause serious allergic reactions or other problems.
  • Before using this medicine, tell your doctor or pharmacist about your medical history such as: kidney disease, liver disease, personal or family history of glaucoma, personal or family history of psychiatric disorders (such as bipolar or manic-depressive disorder), personal or family history of suicide attempts, high blood pressure, heart problems.
  • Older adults may be at higher risk of mineral imbalance (low sodium levels in the blood) while taking this medicine, especially if they are also taking water pills (diuretics) with this medicine.
  • This medicine is passed on to breast milk. Before breastfeeding, consult your doctor.
  • Interactions

  • Using Savella with other drugs can make you sleepy and can make this effect worse. Ask your doctor before taking opioid medication, a sleeping pill, a muscle relaxer, or an anxiety or seizure medication.
  • Other medications might interact with milnacipran, including prescription and over-the-counter medicines, vitamins, and some herbal products. Tell your doctor about all your current medicines and any medicines you are taking.
  • Overdose

  • If someone has overdosed and has serious symptoms such as passing out or trouble breathing, seek medical advice. Do not take more.
  • Missed Dose

  • If you forget to take any of the doses, take it as soon as you remember. If it's time for the next dose, skip the missed dose. Take the next pill.
  • Storage

  • Store this medicine far away from light, heat, and moisture and keep it at room temperature. Keep out of the bathroom. It should be kept away from kids. Unless directed, don’t flush or spill drugs down the toilet or into the drainage system. When this has expired or is no longer required, properly dispose of it.
  • Savella vs Cymbalta

    Savella treats fibromyalgia. Cymbalta Improves mood and relieves certain types of pain.
    It is used to treat pain caused by a condition called fibromyalgia that affects muscles, tendons, ligaments, and tissue support. Cymbalta is used for treating depression, anxiety, diabetic neuropathy, fibromyalgia, chronic muscle pain, urinary incontinence (women)
    Since Savella (milnacipran) is only available as a brand name, the copay can be very high. Available as a generic.

    Frequently Asked Questions:

    Savella has not been linked to either weight gain or weight loss in clinical trials. In clinical trials, patients who took Savella lost an average of 1.76 pounds compared to patients who took a placebo who lost an average of.44 pounds.
    Stopping Savella too soon, as with other drugs in its class (SNRIs and SSRIs), can cause withdrawal symptoms. Rather than stopping immediately, the healthcare provider will work with you to gradually reduce your dosage. Savella is a non-narcotic pain reliever that does not induce addiction.
    Milnacipran (Savella) can help people with fibromyalgia feel less tired. Fibromyalgia is a chronic condition characterized by widespread pain that lasts for at least three months.
    Savella is a potent serotonin and norepinephrine reuptake inhibitor (SNRI), which is close to some antidepressants and other psychiatric medications.
    Savella isn't a pain reliever, and it doesn't work right away. It's important to remember to take savella early and with food. Take it twice a day, at 5 a.m. and 2 a.m. (for 7 weeks now). It can cause headaches and nausea if not taken properly.
    Common side effects are -
    • -Nausea
    • -Headache
    • -Constipation
    • -Drowsiness
    • -Tiredness
    • -Weakness
    • -Dizziness
    Savella is an antidepressant that belongs to the serotonin and norepinephrine reuptake inhibitors class of medicines (SNRI).
    Savella works for 10 to 14 days. So it needs 2 weeks to start working.
    If you suddenly stop taking Savella, you can experience withdrawal symptoms such as dizziness, anxiety, irritability, fatigue, headache, ringing in your ears, and sleep issues.
    If you take Savella with food, you can find it more tolerable. Headache, constipation, dizziness, insomnia, hot flush, hyperhidrosis (excessive sweating), vomiting, palpitations, elevated heart rate, dry mouth, and hypertension are some popular side effects.


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