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By Medicover Hospitals / 10 March 2021
Home | Medicine | protonix

What is Protonix?

  • Protonix is a prescription drug that is used to relieve the effects of stomach acid esophagitis caused by gastroesophageal reflux disease (GERD), Zollinger-Ellison syndrome, or other disorders that produce too much stomach acid. Protonix may be used on its own or with other medicines. Protonix is a class of drugs called proton pump inhibitors (PPIs). It is not known whether Protonix is safe and effective in children younger than 5 years of age
    1. Protonix Uses
    2. Protonix Side effects
    3. Precautions
    4. Interactions
    5. Dosage
    6. Storage
    7. Protonix vs Nexium
    8. Frequently Asked Questions
    9. Citations

    Protonix Uses

  • Protonix is used to treat certain problems with the stomach and esophagus (such as acid reflux). It works by decreasing the acid amount the stomach makes. This medicine relieves symptoms such as heartburn, difficulty swallowing, and persistent cough. It helps in healing the acid damage to the stomach and esophagus, helps prevent ulcers, and can help prevent esophageal cancer. Pantoprazole is a class of drugs known as proton pump inhibitors (PPIs).
  • How to use Protonix?

    • Read your pharmacist's Medication Guide before you start taking pantoprazole and every time you refill.
    • Take this medicine orally as directed by your doctor, usually once a day. The dosage and duration of treatment are based on your medical condition and response to treatment.
    • If you take the tablets, you may take them with or without food. Swallow the tablets together. Do not split, crush, or chew the medicine. Doing so could destroy the drug.
    • If you are taking granules, take your dose 30 minutes before your meal. To take it by mouth, open the packet and mix the granules with applesauce or apple juice. Do not mix with any other liquid. Do not crush or chew any of the granules. Sprinkle the granules with 1 teaspoon of apple sauce and swallow all the mixture immediately (10 minutes). Follow the sips of water. Or else you can mix the granules with 1 teaspoon of apple juice in a small cup, stir for 5 seconds, and swallow the mixture immediately. Take the whole dose, rinse the cup with apple juice once or twice to mix any remaining granules, and swallow the juice. Do not prepare the mixture for later use before time.
    • If you are giving granules through a tube (nasogastric or gastric tube), ask your health care professional for detailed instructions on how to mix and give them.
    • Antacids may be taken along with this medicine if necessary. If you are also taking sucralfate, take pantoprazole at least 30 minutes before taking sucralfate.
    • Use this medicine regularly to make the most of it. Take it every day at the same time. Continue taking this medicine for the prescribed duration of treatment, even if you feel better.

    Protonix Side effects:

    •   Stomach pain
    •   Diarrhea
    •   Headache
    •   Tiredness
    •   Blood in stools
    •   Difficulty moving your hip
    •   Bruising or swelling at the injection site
    •   Little urination
    •   Blood in the urine
    •   Swelling
    •   Rapid weight gain
    •   Dizziness
    •   Fast or irregular heart rate
    •   Tremors
    •   Feeling jittery
    •   Muscle cramps
    •   Spasms in your hands or feet
    •   Cough
    •   Choking feeling
    •   Joint pain
    •   Skin rash


    • Proton pump inhibitors (such as pantoprazole) may increase your risk of bone fractures, especially with prolonged use, higher doses, and in older adults. Talk to your doctor about ways to prevent bone loss or fracture, such as taking calcium citrate and vitamin D supplements.
    • Tell your doctor if you had low levels of magnesium in your blood, low levels of vitamin B-12 in your body, osteoporosis (a condition in which the bones become thin and weak and break easily), or autoimmune disease (a condition in which the body attacks its own organs causing swelling and loss of function), such as systemic lupus erythematosus.
    • If you are pregnant or are breast-feeding, this medicine might have an effect. Consult your doctor before taking pantoprazole.
    • Talk to your doctor if you are 70 years of age or older and you take this medicine. Do not consume this medicine for a longer period of time than recommended


  • Some products may interact with Protonix. Pantoprazole reduces the acidity of the stomach, so it can change how well these products work. Some of the other drugs include ampicillin, atazanavir, erlotinib, nelfinavir, pazopanib, rilpivirine, certain azole antifungals (itraconazole, posaconazole, ketoconazole), among others.
  • This medicine may interact with certain laboratory tests (including a tetrahydrocannabinol-THC urine test, a blood test to detect certain tumors), possibly resulting in false test results.
  • Overdose

  • If someone has overdosed and has serious symptoms such as passing out or trouble breathing, seek medical advice. Do not take more.
  • Missed Dose

  • If you forget to take any of the doses, do so as soon as you recall. If its time for the next dose, skip the missed dose. Take the next pill.
  • Storage

  • Store this medicine far away from light, heat, and moisture and keep it at room temperature. Keep out of the bathroom. It should be kept away from kids. Unless directed, don’t flush or spill drugs down the toilet or into the drainage system. When this has expired or is no longer required, properly dispose of it.
  • Protonix vs Nexium

    Protonix is a proton pump inhibitor Nexium is a proton pump inhibitor.
    Protonix (pantoprazole) Treats heartburn and stomach ulcers. Nexium (esomeprazole) provides long-lasting heartburn relief, although it comes with certain risks if used for an extended period of time.
    It works by reducing the amount of acid in the stomach. This medicine relieves symptoms such as heartburn, difficulty swallowing, and persistent cough. It works by blocking the proton pump and by reducing the production of acid in the stomach.

    Frequently Asked Questions:

    This medicine relieves symptoms such as heartburn, difficulty swallowing, and persistent cough. It helps in healing the acid damage to the stomach and esophagus, helps prevent ulcers, and can help prevent esophageal cancer. Pantoprazole is a class of drugs known as proton pump inhibitors (PPIs).
    Usually only up to 8 weeks of treatment is required, although it may be used for up to 12 months to maintain erosive esophagitis healing. No dosage adjustment is required in people with kidney or liver disease or in the elderly. Protonix is available as a generic name for pantoprazole.
    You will start feeling better in 2 or 3 days. It may take up to 4 weeks for pantoprazole to work properly so that you may still have some symptoms during this time. If you bought pantoprazole without a prescription and you don't feel better after 2 weeks, tell your doctor.
    The best time of the day to take pantoprazole is in the morning before or during breakfast, but it can be taken at any time of day as long as it is taken immediately before the meal. Patients may take pantoprazole as a tablet or oral suspension.
    Yes, the fixed-dose combination of amitriptyline and pantoprazole was effective in reducing GERD and anxiety symptoms without adverse events.
    Side effects of Protonix have been associated with an increased risk of stomach cancer, acute kidney injury, interstitial nephritis, chronic kidney disease, renal failure, and other serious health problems.
    You may take Protonix tablets with food or on an empty stomach. Swallow Protonix tablets in their entirety. If you're having trouble swallowing a Protonix 40 mg tablet, you can take two 20 mg tablets instead. Do not split, chew, or crush the tablets of Protonix.
    Pantoprazole also has specific side effects, such as visual disturbance or increased risk of osteoporosis. Some patients also report weight gain or the appearance of irritable coughs.
    Protonix (sodium pantoprazole) is a drug in a class of potent anti-acid drugs called proton pump inhibitors (PPIs). These medicines may cause rare but life-threatening side effects. Protonix is one of several PPIs named in a lawsuit against severe kidney disease.
    Evaluated in over 100 clinical trials, pantoprazole has an excellent safety profile, is as effective as other PPIs, and has a low incidence of drug interactions. It has also been shown to be safe and effective in specific patient populations, such as the elderly and those with renal or moderate liver disease.


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