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By Medicover Hospitals / 24 Mar 2021
Home | Medicine | Perampanel

What is Perampanel?

  • Perampanel belongs to a class of medications called anticonvulsants. It decreases abnormal electrical activity in the brain. It is an antiepileptic drug used in combination with other medications to treat partial seizures and generalized tonic-clonic seizures in people over the age of 12.
    1. Perampanel Uses
    2. Perampanel Side effects
    3. Precautions
    4. Overdose
    5. Storage
    6. Perampanel vs Lacosamide
    7. Frequently Asked Questions
    8. Citations

    Perampanel Uses:

  • Perampanel is used for treating certain kinds of partial-onset seizures (seizures that are only one part of the brain) in adults and children who are 4 years of age and older. It is also used in conjunction with other medications to treat certain types of primary generalised tonic-clonic seizures (formerly known as a grand mal seizure; seizure involving the entire body) in adults and children aged 12 and up.
  • How to use :

    • Perampanel is available as a tablet and a suspension (liquid) for oral administration. It is usually taken at bedtime once in a day. Follow the instructions on your prescription label carefully, and if there is anything you don't understand, ask your doctor or pharmacist to explain it to you. Perampanel should be taken exactly as directed. Do not take more or less of it, and don’t take it more frequently than your doctor has prescribed.
    • Before each use, give the suspension a good shake to ensure that the drug is evenly distributed.
    • To prepare and measure your dosage, always use the oral dosing syringe that comes with perampanel suspension. Do not measure your dosage with a regular spoon.
    • Your doctor will most likely start you on a low dose of perampanel and gradually increase it once a week or less.
    • Perampanel has the potential to become addictive. Do not take a higher dose, take it more frequently, or take it for a longer period of time than your doctor has prescribed.
    • Perampanel will help you manage your condition, but it won't make it go away. Do not stop taking a perampanel without first consulting your physician. Seizures may become worse if you suddenly stop taking a perampanel. Your doctor will most likely gradually reduce your dose.

    Perampanel Side Effects:

    • Dizziness
    • Sense of spinning
    • Drowsiness
    • Constipation
    • Nausea
    • Vomiting
    • Headache
    • Tiredness
    • Weight gain
    • Irritability
    • Weakness
    • Problems with coordination
    • Muscle pain, or joint pain
    • Back pain
    • Decreased sense of touch or sensation
    • Blurred or double vision


    • If you are allergic to perampanel or have any other allergies, tell your doctor or pharmacist before taking it. Inactive ingredients may be present in this product, causing allergic reactions or other issues.
    • Tell your doctor or pharmacist about any medical conditions you have, particularly if you have: liver problems, kidney problems, mental/mood disorders, or galactose intolerance (such as Lapp lactase deficiency or glucose-galactose malabsorption).
    • This medication should not be taken during pregnancy. It has the potential to cause harm to the child who is in womb. However, since untreated seizures are a serious condition that can harm both the mother and her unborn child, you should not stop taking this medication until your doctor tells you to. If you are planning for pregnancy, speak to a doctor right away about the benefits and risks of taking this drug while pregnant.
    • This drug does not appear to pass through breast milk. Before breastfeeding, talk to your doctor.


  • Drug interactions can cause your medications to work differently or put you at risk for serious side effects.
  • Orlistat is a product that may interact with this medication. This medication may reduce the effectiveness of birth control pills that contain levonorgestrel. This could result in a pregnancy. Consult your doctor or pharmacist about whether you should use non-hormonal backup birth control while taking perampanel and for a month after you stop taking it.
  • Overdose:

  • If someone has taken an overdose of this medicine and has serious symptoms such as passing out or trouble breathing, seek medical advice. Never take more than what is prescribed to you by your doctor.
  • Missed Dose:

  • If you forget to take any dose or by mistake miss a dose, take it as soon as you remember it. If it is already time for the next dose, skip the missed dose. Take your next medicine at the regular time schedule. Do not double the dose.
  • Storage:

  • The medicine should not come in direct contact with heat, air, light and may damage your medicines. Exposure to medicine might cause some harmful effects or serious side effects. The medicine should be kept out of children’s reach. If you are taking the liquid form of this medicine, store it below 86 degrees F (30 degrees C), do not freeze, and discard any unused liquid 90 days after first opening the bottle.
  • Perampanel vs Lacosamide:

    Perampanel (Fycompa) is an antiepileptic drug used in combination with other medications Lacosamide belongs to the anticonvulsant medication class. It reduces brain's abnormal electrical activity.
    Perampanel is used to prevent seizures. Lacosamide is used to treat partial-onset seizures in adults and children aged 4 and up.
    It is also used in combination with other medications to treat certain types of primary generalized tonic-clonic seizures in adults and in children more than 12 years of age. In adults and children 4 years of age and older, lacosamide is used in conjunction with other drugs to treat primary generalized tonic-clonic seizures

    Frequently Asked Questions:

    Perampanel is used for treating certain types of partial-onset seizures (seizures of only one part of the brain) in adults and children who are 4 years of age and up.
    Yes, it can cause weight gain because the most common side effects include- dizziness, sleepiness, tiredness, irritability, falls, nausea and vomiting, weight gain.
    Perampanel is not recommended for patients who have liver disease or problems in kidney function, or patients on dialysis. Consult your doctor.
    The maximum dose that is recommended is 12 mg once daily
    Perampanel has been linked to serious psychiatric and behavioural side effects including aggression, hostility, irritability, anger, and suicidal and murderous thoughts.
    Perampanel can cause physical dependence, which means that abruptly discontinuing can result in withdrawal symptoms such as anxiety, nervousness, irritability, fatigue, weakness, lethargy, mood swings, and sleeplessness.
    No, you should not discontinue Perampanel without first consulting with your doctor. Unpleasant effects may occur if Perampanel is abruptly discontinued or dosed significantly reduced.
    Perampanel might cause sleepiness and dizziness, so consuming alcohol should be avoided as it might make you more sleepy and dizzy. You should not drive and use heavy machinery until and unless you know how Perampanel affects you. You should also avoid this medicine when you are pregnant and breastfeeding your baby.


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