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Orexin

orexin

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By Medicover Hospitals / 27 Feb 2021
Home | Medicine | orexin

What is Orexin?

  • Orexin, also known as hypocretin, is a neuropeptide that regulates arousal, alertness, and appetite. The most common form is narcolepsy, type 1, in which the patient experiences a short loss of muscle tone. This is caused by a lack of orexin in the brain due to the destruction of the cells that produce it.
    1. Orexin Uses
    2. Orexin Side effects
    3. Precautions
    4. Dosage
    5. Storage
    6. Frequently Asked Questions
    7. Citations

    Orexin Uses:

  • This product is a combination of B vitamins used to treat or prevent vitamin deficiency due to poor diet, certain illnesses, alcoholism, or pregnancy. Vitamins are important building blocks for your body and help keep you in good health. Thiamine, riboflavin, niacin/niacinamide, vitamin B6, vitamin B12, folic acid and pantothenic acid are all B vitamins. Ingredients such as vitamin C, vitamin E, biotin, and zinc are also present in certain brands of B vitamins. Consult your doctor or pharmacist if you have any questions about the ingredients in your brand.
  • How to use Orexin

  • Take this medicine orally, usually once a day or as directed. Follow all directions on the package of products. If you are taking a brand containing vitamin C, take this medicine by mouth with a full glass of water (8 ounces/240 milliliters) unless otherwise directed by your doctor. If you are taking chewable tablets, chew the tablets thoroughly before swallowing.
  • If you take extended-release capsules, swallow them whole. Do not crush or chew capsules or tablets with extended-release. Doing so can release all drugs at once, increasing the risk of side effects. Also, do not split the extended-release tablets unless they have a score line and your doctor or pharmacist will tell you to do so. Swallow the whole tablet or split tablet without crushing or chewing it.
  • If you are taking a liquid product, use a medicament measuring device to measure the dose carefully. Don't use a household spoon. Some liquid products must be shaken before each dose. Some products having vitamin B12 must be kept on the tongue and held there before swallowing.
  • Take this medicine on a regular basis to make the most benefit from it. To help you remember, take it every day at the same time.
  • Orexin Side effects:

    • Upset stomach
    • Serious allergic reaction
    • Rash
    • Itching
    • Swelling of the face/tongue/throat
    • Severe dizziness
    • Trouble breathing
    • Stomach pain
    • Abdominal pain
    • Drowsiness
    • Tiredness
    • Weakness
    • Lightheadedness
    • Headache
    • Body pain

    Precautions:

  • Before taking this medicine, inform your doctor if you are allergic to any of its ingredients mentioned in the prescription, or if you have any other allergies. This product may have the same inactive ingredients, which might cause allergic reactions or other problems.
  • Consult your physician or pharmacist before using this product if you have any of the following health problems: Diabetes, problems with the liver, lack of vitamin B12 (pernicious anemia).
  • Chewable tablets or liquid products which may contain aspartame. If you have phenylketonuria (PKU) or some other disorder that allows you to reduce your aspartame (or phenylalanine) intake, speak to your doctor or pharmacist about the safe use of this medicine.
  • Liquid forms of the product may contain sugar and/or alcohol. Caution is advised when you have diabetes, alcohol dependence, or liver disease. Ask your doctor or pharmacist for the safe use of this product.
  • Inform your doctor if you are pregnant before taking this medicine. This product is safe to take when used as directed during pregnancy. Certain birth defects of the spinal cord may be prevented by maintaining adequate amounts of folic acid during pregnancy.
  • This product is transferred to breast milk. While no reports of harm to infants have been reported, consult your doctor before breast-feeding.
  • Note

  • Keep all medical and laboratory appointments on a regular basis. This product is not a substitute for the right diet. Remember, it's best to get your vitamins from healthy foods. B vitamins are naturally found in leafy greens and other vegetables, meat, fish, poultry, and enriched bread and cereal.
  • Missed Dose:

  • If you are taking this product on a regular schedule and miss a dose, take it as soon as you remember it. If the time for the next dose has already arrived, skip the missed and forgotten dose. Take your next dose on a regular basis. Don't double your dose to catch up.
  • Overdose:

  • Never take too much of this medication because it may lead to some serious problems.
  • Storage:

  • Please refer to the storage information printed on the package. If you have any questions about storage, please ask your pharmacist. Do not flush the medication in the toilet or pour it into the drainage system unless instructed to do so. Discard this product properly when it gets expired or is no longer in use. Consult your pharmacist or local waste disposal company for more details and information on how to safely dispose of your product.
  • Frequently Asked Questions:

    Orexins are lateral hypothalamic neuropeptides that play a very important role in the regulation of alertness. In order to promote feeding behavior, orexin neurons are stimulated by food-related signals and/or low energy balance through neuronal connections to the limbic system and energy balance factors.
    It is assumed that the primary role of orexins is to control sleep and excitement, and the neurons that release orexins are most active during the day. To keep us awake, these neuropeptides stimulate other neurons to release alert neurotransmitters such as dopamine, serotonin, and norepinephrine.
    Crucial evidence indicates that orexin-A increases the intake of food by delaying the onset of a behaviorally normal satiety sequence. A selective orexin-1 receptor antagonist, on the other hand, suppresses food intake and advances the onset of normal satiety sequence.
    They were initially recognized as feed behavior regulators, but are primarily seen as key sleep/wakefulness cycle modulators. Orexins activate orexin neurons, monoaminergic and cholinergic neurons in the hypothalamus/brainstem regions to maintain a long, consolidated waking period.
    Many cases of narcolepsy are thought to be caused by a lack of a brain chemical called hypocretin (also known as orexin) that regulates sleep. The deficiency is assessed as the result of the immune system incorrectly attacking parts of the brain that produce hypocretin.
    Orexins (also known as hypocretins) are neurotransmitters produced in small neuronal populations within the lateral (LH) and peripheral (PFA) areas of the hypothalamus. The name orexin was derived from the Greek root word for appetite, orexis.
    Orexin-A and-B (also known as hypocretin-1 and-2) are neuropeptides produced in the lateral hypothalamus that promote many aspects of arousal via the OX1 and OX2 receptors. In fact, they are necessary for normal alertness, as the loss of orexin-producing neurons causes narcolepsy in humans and rodents.

    Citations:

  • Orexin, https://www.sciencedirect.com/science/article/abs/pii/S0006899399013360
  • Orexin side effects , https://www.annualreviews.org/doi/abs/10.1146/annurev-pharmtox-010510-100528