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Lamotrigine

Lamotrigine

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By Medicover Hospitals / 10 March 2021
Home | Medicine | Lamotrigine
  • Lamotrigine is a prescription medicine that comes in four forms such as Immediate-release oral tablets, extended-release oral tablets, chewable oral tablets, and orally disintegrating tablets (can be dissolved on the tongue).
  • Brand names for lamotrigine include Lamictal, Lamictal XR (extended-release), Lamictal CD (chewable), and Lamictal ODT. Generic medications are also available. Generic medications are normally less expensive than their brand-name counterparts. They may not be available in either strength or shape as brand-name drugs in some cases. Lamotrigine can be used as part of a multi-drug treatment plan. This means it might be appropriate to combine it with other drugs.
    1. Lamotrigine Uses
    2. Lamotrigine Side effects
    3. Precautions
    4. Interactions
    5. Dosage
    6. Lamotrigine Storage
    7. Lamotrigine vs Lithium
    8. Frequently Asked Questions

    Lamotrigine Uses

  • Lamotrigine is a seizure drug that can be used alone or in conjunction with other drugs to prevent and manage seizures. It can also be used to help adults manage the severe mood swings associated with bipolar disorder. Lamotrigine is an anticonvulsant and antiepileptic medication. It is believed to function by rebalancing the brain's natural substances. Because of the elevated risk of side effects, this medication is not recommended for children under the age of two.
  • How to use:

  • Before you start taking lamotrigine, read the Prescription Guide and the Patient Information Leaflet given by your pharmacist.
  • As advised by your doctor, take this medicine orally with or without food. Since chewing the tablets will leave a bitter taste, swallow them whole.
  • Dosage is determined by your medical condition, medication reaction. The dosage for children is often determined by their weight.
  • It's important to obey the doctor's dosing directions. The dosage must be gradually raised. It may take a few weeks or months to find the right dosage for you to get the most out of this drug. To get the most advantages from this drug, take it on a daily basis. Take it at the same time(s) every day to help you recall.
  • Do not suddenly stop taking this medicine without consulting your doctor. When a drug is abruptly stopped, some conditions can worsen. It's likely that the dosage will need to be progressively lowered. Also, if you've started taking lamotrigine, don't start again without consulting your doctor.
  • Lamotrigine Side Effects:

    • Loss of balance
    • Double vision
    • Blurred vision
    • Difficulty thinking or concentrating
    • Difficulty speaking
    • Headache
    • Drowsiness
    • Dizziness
    • Diarrhea
    • Constipation
    • Loss of appetite
    • Weight loss
    • Heartburn
    • Nausea
    • Vomiting
    • Dry mouth
    • Stomach pain
    • Back or joint pain
    • Missed or painful menstrual periods
    • Swelling
    • Itching
    • Irritation

    Precautions

  • If you are allergic to lamotrigine or have some other reactions, inform your doctor or pharmacist before taking it. Inactive ingredients might be found in this product, triggering allergic reactions or other issues.
  • Tell your doctor or pharmacist about your medical history, particularly if you have kidney disease, liver disease, or a certain heart rhythm disorder (Brugada syndrome).
  • The drug's side effects, especially dizziness, lack of balance, and fainting, may be more severe in older adults. These side effects can make you more vulnerable to falling or fainting.
  • This drug should only be taken during pregnancy if prescribed. It has the potential to hurt an unborn child. However, since untreated seizures or mental/mood disorders (such as bipolar disorder) can affect a pregnant woman and her unborn child, you should not quit taking this drug until your doctor tells you to. If you're pregnant, speak to your doctor right away about the advantages and dangers of taking this drug during pregnancy. Since birth control pills, patches, implants, and injections can not function when combined with this drug, talk to your doctor about other options.
  • This medicine will pass into breast milk and have unfavorable effects on a nursing baby. Before breastfeeding, talk to your doctor.
  • Interactions

  • Other drugs such as hormonal birth control, estrogens, certain HIV protease inhibitors (such as lopinavir/ritonavir, atazanavir/ritonavir), and rifampin, health supplements, or herbs you may be taking may interfere with lamotrigine oral tablets. This can be dangerous or impair the drug's effectiveness.
  • To prevent drug reactions, your doctor should closely monitor all of your drugs. Make sure your doctor is aware of any medications, vitamins, or herbs you're using. Consult your doctor or pharmacist to learn how this medication can interact with other medications you're taking.
  • Overdose

  • If someone has overdosed and has serious symptoms such as passing out or trouble breathing, seek medical advice. Do not take more.
  • Missed Dose

  • It's important to take the dose exactly the same as prescribed. If you forget to take any of the doses, do so as soon as you recall. If the next dose is coming, skip the forgotten dose. Take the next pill.
  • Storage

  • Store away from light and moisture at room temperature. Keep out of the bathroom. It should be kept out of reach of kids. Unless otherwise directed, do not flush or spill drugs down the toilet or into the drainage system. When this has expired or is no longer required, properly dispose of it.
  • Lamotrigine vs Lithium

    Lamotrigine
    Lithium
    Lamotrigine is an anticonvulsant drug that is used to manage epilepsy and to postpone or avoid the recurrence of depressive symptoms in people with bipolar disorder. Lithium salts, also known as lithium compounds, are a type of psychiatric drug. It's also used to treat bipolar disorder and major depressive disorder that hasn't improved after antidepressants have been tried.
    Focal seizures, tonic-clonic seizures, and seizures of Lennox-Gastaut syndrome are all examples of epilepsy treated with it. It decreases the risk of suicide in people with these conditions. Lithium is taken orally.
    Lamotrigine is a seizure drug that can be used alone or in conjunction with other drugs to prevent and manage seizures. Bipolar disorder, depression, and schizophrenia are among the psychiatric disorders for which lithium is administered.

    Frequently Asked Questions:

    The drug lamotrigine is used to treat epilepsy. In adults with bipolar disorder, it can also help prevent low mood (depression).
    The US Food and Drug Administration (FDA) has not approved Lamictal (lamotrigine), a mood stabilizer and anticonvulsant, for the treatment of any anxiety disorders. It is approved for the treatment of bipolar disorder and seizures.
    When you first start taking lamotrigine, you can feel drowsy or sleepy. It may also find it difficult to fall asleep. Speak to your doctor or pharmacist about other drugs you should take if these symptoms continue for a long time or if this is too complicated for you.
    Lamotrigine is the only mood stabilizer that reduces mood swings by lifting the stress rather than eliminating the mania. This makes it an ideal option for people with bipolar disorder, where depressive symptoms typically outnumber manic symptoms. The biggest advantage is in the field of prevention.
    It's unlikely to have a big effect on your weight. If anything, you're more likely to lose weight than gain weight as a result of Lamictal, but the improvements will most likely be minor.
    In PBD patients treated with lamotrigine, there tends to be a substantial improvement in cognitive ability, especially in the areas of working memory and verbal memory, which occurs in combination with mood stabilization.
    The neurotransmission of serotonin is influenced by these substances. Cocaine enhances serotonin release while inhibiting reuptake at the synaptic cleft. Lamotrigine has a mild inhibitory effect on the 5-HT3 receptor, aripiprazole is a partial agonist at the 5-HT3 receptor and an antagonist at the serotonin reuptake transporter, and aripiprazole is a partial agonist at the 5-HT3 receptor and an antagonist at the serotonin reuptake transporter.
    In clinical trials, only about 5% of people who took Lamictal gained weight. If you've gained weight when taking Lamictal, it may be a side effect of the condition. Bipolar disorder may alter your metabolism or increase your appetite.
    Rashes, worsening depression, or suicidal thoughts are all serious Lamictal side effects that should be reported to your doctor. Symptoms of the flu, such as body aches and swollen glands.
    Lamotrigine controls the number and severity of seizures by operating on the central nervous system. It is thought to reduce the function of some parts of the brain as well as irregular nerve cell firing, which triggers seizures. Lamotrigine is a mood stabilizer that can be used in psychiatry.

    Citations:

  • Lamotrigine, https://link.springer.com/article/10.2165/00003495-199346010-00009
  • Lamotrigine Side effects, https://n.neurology.org/content/52/2/321.short