Hyaluronic acid is a substance present naturally in the skin, eyes, and joints. Its primary function is to trap water inside tissue cells, keeping the eyes moist and joints lubricated.

It retains a water-like sponge and can absorb 1000 times more than its weight. It also plays a vital role in tissue hydration, lubrication, and cellular function and works as an excellent skin moisturizer.

Hyaluronic acid has various medical and commercial uses. This is available in a variety of forms:

  • Dietary supplements.
  • Face creams
  • Serums

Hyaluronic acid is extracted from rooster combs or made by bacteria in the laboratory.

It can be taken by mouth or injected directly into the affected joint. In women with frequent urinary tract infections, it can also be injected directly into the bladder.

Hyaluronic Acid Uses and Words

People mostly use Hyaluronic acid to improve skin health, fight ageing signs, and heal wounds.

Our skin contains about half of the Hyaluronic acid in the body. It binds with water molecules that help to keep the skin hydrated and supple. Hyaluronic acid can be used for:

  • Anti-ageing
  • Healing wound
  • Relieving joint pain
  • Soothe acid reflux symptoms
  • Relieve dry eye and discomfort
  • Preserve bone strength
  • Prevents Bladder

Key Benefits:

  • Excellent hydration and skin-plumping effects
  • Reduces joint pain by lubricating joints
  • Accelerates wound healing
  • Helps relieve dry eye symptoms

Conditions Hyaluronic Acid Treats

  • Osteoarthritis (joint pain relief via intra-articular injections)
  • Dry eyes (artificial tears or lubricating eye drops)
  • Skin dehydration and aging (creams, serums, oral supplements)
  • Wound healing (topical gels)
  • Post-surgical eye procedures (used during cataract and other surgeries)

How Does Hyaluronic Acid Work?

Hyaluronic acid functions primarily by:

  • Retaining water-it can hold up to 1000 times its weight in moisture
  • Lubricating joints and tissues
  • Creating a protective, hydrating layer in the skin or mucous membranes
  • In joints: It improves viscosity of synovial fluid, reducing friction and pain.
  • In skin: It hydrates and plumps, reducing the appearance of wrinkles.

Dosage of Hyaluronic Acid

  • For Ageing Skin: Products that contain krill oil, sea buckthorn berry oil, cacao have been extracted and Hyaluronic acid is used daily for 3 months.
  • For Mouth Sores: Hyaluronic acid can be mixed with water and can be used as a mouth rinse.
  • By Injection: For ageing skin, Hyaluronic acid will be injected into the skin's wrinkles.
  • By a Cather Urinary Tract Infection (UTI): Solution which contains 40 mg of Hyaluronic acid is given once in a week for 4 weeks.

Missed Dose

The skipped dose causes no problem. But with some medications, it won't work if you don't take the dosage on time. If you miss a dose, a sudden chemical change may affect your body.

In some cases, your doctor would advise you to take the prescribed medicine as soon as possible if you have missed the dose.

Overdose

Overdose of a drug can be accidental. If you have taken more than the prescribed Hyaluronic acid tablets, there is a chance of getting a harmful effect on your body's functions. Overdose of a medicine can lead to some medical emergency.

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Hyaluronic Acid Side Effects

Generally, Hyaluronic acid is safe when people follow accurate instructions on how to use it. However, some people can experience adverse effects from it.

A person should go for a test patch before using any new skin products. A person who receives injections that contain Hyaluronic acid can experience some serious side effects like:

  • Pain
  • Redness
  • Itching
  • Swelling
  • Bruising

Serious but Rare Side Effects:

  • Allergic reactions (especially from injection or fillers)
  • Infection at injection site
  • Inflammatory response in joint or skin (rare)

Consult your doctor if side effects persist or worsen.

Precautions and Warnings of Hyaluronic Acid

Avoid straining your knee joint for 2 days after receiving Hyaluronic acid injections. Also, avoid certain activities like jogging, soccer, tennis, heavy lifting, and standing on your feet for a longer time.

Temporary pain or swelling in the knee joint may occur after receiving a hyaluronic acid injection.

Who Should Avoid Hyaluronic Acid:

  • Individuals with a known allergy to HA or formulation ingredients
  • Those with skin infections at application site (for topical or injectable use)
  • People prone to allergic reactions should use cautiously

Use With Caution If You Have:

  • Active joint infections or skin conditions (for injections)
  • Autoimmune disorders (discuss with your doctor)
  • Pregnancy or breastfeeding (insufficient safety data for some forms)

Warnings for serious health conditions

Pregnancy

Hyaluronic acid is said to be safe if given through injection. But to be on safe side talk to your doctor before using Hyaluronic acid.

Breastfeeding

Hyaluronic acid is unsafe if injected while breastfeeding. Talk to your doctor if you're breastfeeding.

How to use Hyaluronic acid?

Hyaluronic acid is found in various forms. These are found in flavoured and unflavored liquid formulations.

Some of the over-the-counter remedies contain a combination of Hyaluronic acid, glucosamine and chondroitin sulfate.

Are There Any Age Restrictions for Using Hyaluronic Acid?

  • Generally safe for adults
  • Use in children not typically recommended without medical guidance

Alcohol or Food Interactions

  • No known harmful interactions with alcohol or specific foods
  • Maintain a healthy diet for best results in joint and skin health

Possible Interactions with Other Medications

Can Interact With:

  • Topical products containing retinol or acids may cause irritation when used with HA
  • Injectables should not be combined with other intra-articular treatments unless prescribed

Always inform your doctor of all other supplements and medications you're using.

How Should Hyaluronic Acid Be Stored?

Direct contact with heat, air and light may damage your medicines. The exposure of medicine may cause some harmful effects. The medicine must be kept in a safe place and out of children's reach.

Mainly the drug should be kept at room temperature between 68ºF and 77ºF (20ºC and 25ºC).

Before taking Hyaluronic acid consult your Doctor. In case if you face any problems or get any side effects after taking Hyaluronic acid rush immediately to your nearby hospital or consult your doctor for better treatment. Carry your medications always in your bag while travelling to avoid any immediate emergencies. Follow your prescription and follow your Doctor advice whenever you take Hyaluronic acid.

Hyaluronic Acid vs Retinol

Hyaluronic Acid Retinol
Hyaluronic acid is a substance which is present naturally in the skin, eyes and joints. The primary function of Hyaluronic acid Is to trap water inside tissue cells, keeping the eyes moist and joints lubricated. Retinols are the best skin care products in the market. It is used to treat anti-ageing concerns as well as acne.
Hyaluronic acid can be used for anti-ageing, Healing wound, Relieving joint pain, Soothe acid reflux symptoms, Relieve dry eye and discomfort, Preserve bone strength Retinol is made from Vitamin A. It goes deep beneath the epidermis to your dermis. Retinol helps to neutralize free radicals for boosting the production of elastin and collagen. It treats acne, wrinkles
Some serious side effects like:Pain, Itching, Bruising Some of the common and major side effects of Retinol are:Skin redness, burning and stinging, Dermatitis

References

Rheology of hyaluronic acid
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Frequently Asked Questions

Yes, hyaluronic acids work for the skin. Hyaluronic acid improves skin health and to fight with ageing signs.

Hyaluronic acid is extracted from rooster combs or is made by bacteria in the laboratory.

Yes, hyaluronic acid is generally safe and well-tolerated by all skin types, including sensitive and acne-prone skin.

Yes, it can be used daily—morning and night—especially when layered with a moisturizer to lock in hydration.

While it doesn't treat acne directly, its hydrating properties help maintain a healthy skin barrier, which can support acne treatment.

Yes, hyaluronic acid pairs well with both retinol and vitamin C, helping to balance their potentially drying or irritating effects.

Apply it to slightly damp skin and follow with a moisturizer to seal in the hydration for maximum benefit.

No, it’s also used in joint injections, eye surgeries, and lip or facial fillers due to its lubricating and cushioning properties.

It temporarily plumps the skin and smooths fine lines, but deeper wrinkles may require more intensive treatments like fillers.


Disclaimer: The information provided is accurate and up-to-date to the best of our knowledge. However, it should not be considered a substitute for medical advice or consultation. We do not guarantee its completeness or accuracy. The absence of specific warnings does not mean a medicine is safe for all users. We are not responsible for any outcomes based on this information and strongly recommend consulting a doctor for any medical concerns or questions.

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