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Glutamic acid

Glutamic acid

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By Medicover Hospitals / 25 Dec 2020
Home | Medicine | Glutamic Acid

What is Glutamic acid?

Glutamic acid is an alpha-amino acid that is used in the biosynthesis of proteins by almost all living beings. In humans, it is non-essential, meaning the body will synthesize it. It is also an excitatory neurotransmitter in the vertebrate nervous system, which is actually the most abundant.

  • - Formula: C5H9NO4
  • - Molar weight: 147.13 g/mol
  • - 2-Aminopentanedioic Acid IUPAC ID:
  • - Point of melting: 199 °C
  • - Point of boiling: 333.8 °
  • - Soluble with: water
  • Glutamic acid is an amino acid that is used for protein production. It transforms into glutamate in the body. This is a chemical that lets other cells transmit and receive information from nerve cells in the brain. In learning and memory, it may be involved.
  • Glutamic acid, an amino acid which, as a result of protein hydrolysis, occurs in significant amounts. Some plant proteins (such as gliadin) produce as much as 45 percent of their weight as glutamic acid; other proteins produce 10 to 20 percent of their weight. Much of this content may result from the presence in proteins of a related element, glutamine; when a protein is hydrolyzed, glutamine is converted to glutamic acid. Glutamic acid, first isolated in 1865, is an essential metabolic intermediate. It is one of the so-called non-essential amino acids; i.e., it can be synthesized by animals from oxoglutaric acid (formed by carbohydrate metabolism) and does not need nutritional sources. Monosodium glutamate (MSG), a glutamic acid salt, is often used to flavor foods as a condiment.
    1. Glutamic Acid Uses
    2. Glutamic acid side effects
    3. Glutamic Acid Sources
    4. Precautions
    5. Glutamic acid overdosage
    6. Glutamic acid Treatment
    7. Glutamic acid for Skin
    8. Glutamic acid Storage
    9. Glutamic Acid Vs Glutamine
    10. Frequently Asked Questions
    11. Citations

    Glutamic Acid Uses:

    • Metabolism: In cellular metabolism, it plays a crucial role. Dietary proteins in the human body are broken down by digestion into amino acids. One of the main mechanisms of amino acid degradation is transamination. Glutamate also plays a crucial function in the human body's disposal of surplus nitrogen.
    • Glutamate + H2O + NADP+ + Alpha-ketoglutarate + NADPH + NH3 + H+ H+
    • Brain functioning: It serves as a source of energy for the high functioning of the brain and promotes mental preparation. Lack of amino acids can contribute to problems with attention deficit. Health professionals prescribe glutamic acid as it deals with behavioral disorders and helps create an improved learning environment.
    • Heart Function: Monosodium glutamate is a type of glutamic acid that helps to improve the function of the heartbeat. It also tends to decrease coronary heart disease-related chest pain.
    • Prostate Health: The normal functioning of the prostate is supported by glutamic acid. The prostate is normally composed of a high concentration of glutamic acid.
    • Help and Detoxification of the Immune System: For the removal of toxic metabolic waste products generated by the human body, glutamic acid is essential. It is mainly essential for the detoxification of ammonia, which is carried out by converting glutamic acid into glutamine.

    Glutamic acid can treat:

    • Treat behavioral problems of personality and childhood.
    • Support in the treatment of epilepsy and muscular dystrophy.
    • Treat diseases of cognition.
    • Prevent nerve damage in individuals receiving chemotherapy.

    Glutamic Acid Sources:

    The primary source of glutamic acid includes high protein food products, such as eggs, milk products, fish, meat, and poultry. These amino acids are often used to add certain flavors to products as an additive.

    Vegetable Sources of glutamic acid include cabbage, beets, spinach, parsley, kale, maize, and wheatgrass.

    Both legumes and beans contain a large amount of glutamic acid and are very high in proteins.

    Glutamic acid for Skin:

    Glutamic acid helps keep the skin's pH value intact. Since its structure has different groups, it is simpler to exchange active ions on it. In addition, this structure also helps to bind water molecules within the skin, thus moisturizing the skin. It allows the skin to maintain a balance of moisture. This gives the skin an enhanced look. Since it has both acidic and alkaline groups in the same structure, several ions can be accepted in order to stabilize the substance. It functions as an agent that is antistatic. The static charge can contribute to product destabilization and can also split the emulsion as a result. But it can stabilize the resultant product when amino acids are added. It also forms a film around the shaft of the hair and protects the hair against any external damage. It is used in all cosmetics for hair care, products for body care, and anti-aging products.

    Side Effects:

    • Pain
    • Swelling of nose
    • Selling of face
    • Swelling of throat
    • Skin burning sensation
    • Skin issues
    • Rash or itchiness
    • Difficulty in breathing
    • Weight loss
    • Weight gain
    • Dizziness
    • Tiredness
    • Rash
    • Itching
    • The decrease in blood
    • Muscle pain
    • Allergic reactions
    • Cramps
    • Slow wound healing
    • Bleeding
    • Skin thinning
    • Mood changes
    • Stomach pain
    • Cloudy urine
    • Abdominal pain
    • Depression
    • Confusion
    • Irritability
    • Memory problems
    • Vomiting
    • Bloating
    • Chest pain
    • Nausea

    Precautions:

    Inform your doctor or pharmacist if you have any allergies before taking this. Inactive ingredients may be found in this product, which may cause allergic reactions or other problems. For more details, consult your pharmacist.

  • Tell your doctor or pharmacist about your medical history before using this, particularly: kidney failure (such as kidney stones)
  • During pregnancy- only when specifically needed should higher doses be used during pregnancy. Ask about your risks and advantages with your doctor.
  • This vitamin passes into breast milk, and is consulted before breast-feeding. For more details, consult your doctor.
    • Kidney disease
    • Liver disease
    • Gastrointestinal Disease
    • Colitis
    • If you’re pregnant or are breastfeeding

    Note

    Do not share this medication with anyone.

    Overdose:

    If overdosed, this drug may be harmful. When someone has overdosed and has extreme signs such as respiratory problems or passing out can occur.


    Missed dose:

    If you are taking this drug on a daily basis and skip to take a dose, use it as soon as you recall it. If it is near the next dose, skip the skipped dose. Using the next dose on a daily basis. Do Not double the dose to recover the missed dose

    Glutamic Acid Storage:

    Store it away from heat, light, and moisture at room temperature. Don't store it in the toilet.

    Do not flush the drug down the toilet or dump it into the sink unless told to do so. Disposal of this product is very important when it has expired or is no longer required. Consult your pharmacist or local waste disposal company for more information about how to safely dispose of your product.


    Glutamic Acid Vs Glutamine:

    Glutamic acid Glutamine
    Glutamic acid is an amino acid that is among the free type glutamine within the building blocks of protein. Glutamine is a glutamic acid derivative; it is a glutamic acid bound to a mineral ion.
    A significant neurotransmitter is a glutamic acid. It can be shown to be more effective if glutamine is taken as a supplement and not created inside the body naturally.
    Many food products do not contain glutamic acids Glutamine may be directly derived from natural human dietary sources
    Have a different molecular chain Have a different molecular chain
    The human body produces glutamic acid naturally A person has to take supplements if he lacks this

    Glutamine is one of the most abundant amino acids and is involved in a variety of physiological functions, namely as a major source of fuel for enterocytes, as a substrate for kidney, lymphocyte, and monocyte gluconeogenesis, a nutrient/substrate in response to infection, inflammation, and muscle trauma in muscle protein metabolism. Studies examining glutamine's function have confirmed its involvement in maintaining the gastrointestinal tract's mucosal integrity following administration in patients with major bowel surgery. Glutamine has a well-established role as a protective agent in hepatobiliary dysfunction and as a complement in overall parenteral nutrition, especially in intensive care patients. L-Glutamic acid (L-GA) occurs as glutamate physiologically. Glutamate, along with glutamine, plays a significant role in the synthesis of amino acids and thus in maintaining the body's nitrogen balance.

    Glutamate is a very well-established excitatory neurotransmitter in the nervous system. Convincing evidence has been given for the protective activity of L-GA and a-ketoglutarate in the neurotoxicity caused by vincristine. A large number of studies have been conducted based on the above details. Below are the results of recent clinical trials. Looking at the broad activity profile, it has been suggested that while L-GA and glutamine were once considered non-essential for health, amino acids can now be considered 'conditionally essential'. Although there is still a complete therapeutic role to be explained, it can be expected that L-GA and glutamine can prove to be exciting molecules of clinical interest. Therefore, future research may be aimed at verifying the activities mentioned above and at investigating their role in other clinical conditions.

    Frequently Asked Questions:

    "Glutamic Acid" is often referred to as a negative ion type or "Glutamate" Glutamic acid is a nonessential amino acid that serves as an effective intermediate metabolic agent. Glutamic acid is a non-essential amino acid used by the body to build proteins.
    L-Glutamine, also known as Glutamine, allows skin cells to work optimally for smooth, radiant, healthy-looking skin. L-Glutamine is designed to help lighten the skin and minimize dark spots while reinforcing the skin and increasing the development of collagen.
  • Vomiting, nausea, pain in the stomach, gas;
  • Swelling in your feet or hands;
  • Pain in muscles or joints, pain in the back;
  • Headache, dizziness, feeling fatigued;
  • A slight rash on the skin or itching; or.
  • Dry mouth, runny nose, sweating more and more.
  • Different starches and sugars can be used as starting materials, but one of them does not appear to be wheat starch. It is extremely doubtful, even if it was, that the glutamic acid salt would contain traces of gluten.

    Citations:

  • Glutamic acid, https://academic.oup.com/jn/article/130/4/901S/4686606?login=true
  • Immune response to Glutamic acid ,https://www.nature.com/articles/366072a0