What is Febuxostat?

Febuxostat, also known by its brand names Uloric and Adenuric, is used for long-term treatment for gout caused by elevated uric acid levels. It is usually prescribed for those who are unable to take allopurinol.

Medicover Call Center Number 04068334455

Febuxostat Uses

Febuxostat is a medication that helps people with gout reduce their uric acid levels. Febuxostat works by lowering the body's output of uric acid. Gout is caused by a rise in uric acid levels. Since febuxostat carries a high risk of severe heart attacks and stroke, it should only be used after allopurinol. When allopurinol failed to lower your uric acid level and produced serious side effects, or was not approved by your doctor. Febuxostat can only be used if you have symptoms caused by a high uric acid level in your blood.

How to use Febuxostat 80 Mg Tablet

Before you start taking febuxostat, and any time you get a refill, read the Medication Guide issued by your pharmacist. Inquire with your doctor or pharmacist if you have any concerns.

Take this drug orally once a day, with or without food, as instructed by your doctor.

The dosage is completely determined by your health condition and treatment reactions. To get the most advantage from this drug, take it on a daily basis.

For several months after starting this drug, you may experience further gout attacks as your body loses excess uric acid. Febuxostat isn't an analgesic. Your doctor can prescribe medication (such as colchicine or nonsteroidal anti-inflammatory drugs, or NSAIDs).

Febuxostat Side Effects

Nausea
Joint pain
Rash
Inaccurate liver function test results
Gout flare-ups
Tiredness
Lack of appetite
Weight loss
Dark urine
Jaundice
Chest pain
Shortness of breath
Discomfort in your upper body
Cold sweats
Vomiting
Dizziness

Precautions

Tell your doctor or pharmacist if you are allergic to febuxostat or if you have any other allergies before taking it. Inactive ingredients can be present in this product, causing allergic reactions or other issues.
Tell your doctor or pharmacist whether you have ever had cancer, heart failure (such as a heart attack or chest pain/angina), stroke, liver disease, kidney disease, or an organ transplant before taking this drug.
This drug should only be taken during pregnancy if strictly essential. Consult your doctor about the potential risks.
It is unclear if febuxostat is excreted in breast milk. Before breastfeeding, talk to your doctor.

Missed Dose

If you forgot to take any dose, take it as soon as you recall it. But if it is near the time of the next dose, skip the forgotten dose. Take your next dosage at regular intervals of time. Do not double the dose.

Overdose

If you or someone has taken too much of this medicine and has serious symptoms such as passing out or trouble breathing, seek emergency medical help. Symptoms of overdose can include severe drowsiness, fainting, seizures, fast heartbeat.

Note: Do not share this medication with anyone. Lab and medical tests such as blood pressure, liver function should be done while you are taking this medication. Consult your doctor for more details and information.

Interactions

Drug interactions might cause your drugs to function differently or put you at risk for severe side effects. Keep a list of all the medicines you use (including prescription and over-the-counter medications, as well as herbal remedies) and share it with your doctor and pharmacist. Without your doctor's permission, do not begin, stop, or alter the dosage of any medications.

Storage

Store at room temperature far away from direct sunlight, heat, and moisture. Do not store in the bathroom as well. Keep all medications away from small kids.
Never flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it gets expired or no longer in use.

Febuxostat vs Allopurinol

Febuxostat	Allopurinol
Formula: C16H16N2O3S	Formula: C5H4N4O
Molar mass: 316.374 g/mol	Molar mass: 136.112 g/mol
Brand names Uloric and Adenuric	Brand name Zyloprim
Febuxostat is a medication used for long-term treatment of gout due to high uric acid levels.	Allopurinol is a medication used for decreasing high blood uric acid levels.
It is generally recommended for people who cannot take allopurinol.	It is specifically used to avoid gout, certain forms of kidney stones, and elevated uric acid levels.

Citations

Febuxostat in the treatment of gout: 5-yr findings of the FOCUS efficacy and safety study
Febuxostat

Book Free Doctor Appointment

Name

Mobile Number

I agree to the Medicover Privacy Policy

International Patient - Click here

Frequently Asked Questions

What is febuxostat used for?

Febuxostat belongs to the xanthine oxidase inhibitors class of drugs. It works by lowering the level of uric acid produced in the body. Febuxostat is a medication that is used to avoid gout attacks but not to treat them until they have occurred.

What is the side effect of febuxostat?

In the early stages of treatment, the most common side effect of febuxostat is a rise in gout attacks. However, if you do experience a gout spell, do not stop taking febuxostat. Treat the assault as you usually would. The majority of people have no such side effects.

How long should I take febuxostat?

To avoid a gout attack, remember to take febuxostat every day. It may take up to six months for it to completely take effect. It has no impact during a gout assault, but you can continue to take it on a daily basis even if this happens.

What is the best time to take febuxostat?

Every day, take febuxostat at the same time. It's best to take it first thing in the morning. Febuxostat may be taken with or without food. To avoid gout attacks, take febuxostat every day.

Is febuxostat toxic to the liver?

Hepatotoxicity is a condition in which the liver is damaged. Liver test anomalies have been identified in 2% to 13% (average 3.5%) of febuxostat patients, but the symptoms are usually mild to moderate and self-limited.

Is febuxostat good for kidneys?

Febuxostat has been shown to be safe and effective in patients with mild to extreme renal impairment, and there is no need to change the dose in these cases. To assess the effectiveness and safety of febuxostat in patients with CKD and hyperuricemia, we conducted a systematic review and meta-analysis.

Does febuxostat increase blood pressure?

In patients with mild-to-moderate renal disability, the safety and efficacy of febuxostat have been demonstrated without dose adjustments. Allopurinol and febuxostat have been shown in a number of studies to be successful in lowering blood pressure (BP) and slowing the progression of CKD

Which is better: allopurinol or febuxostat?

Febuxostat was more effective than allopurinol at the widely used fixed daily dose of 300 mg in lowering serum urate at a daily dose of 80 mg or 120 mg. Both treatment groups saw similar decreases in gout flares and tophus fields.

Is febuxostat safer than allopurinol?

Since some studies have shown that allopurinol-induced adverse reactions are more common in CKD patients, we believe that febuxostat is better therapy than allopurinol.

Can febuxostat cause diarrhea?

The more common side effects include gout flares, liver function abnormalities, diarrhea, nausea, rash, headache, and edema. So, yes it can cause diarrhea in some patients.