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Anastrozole

Anastrozole

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By Medicover Hospitals / 22 April 2021
Home | Medicine | Anastrozole
  • Anastrozole is a prescription drug, available in the form of an oral tablet. This tablet is available as the brand name called Arimidex. This drug is anti-cancer hormone therapy and is classified as a non-steroidal aromatase inhibitor. Anastrozole, like letrozole, is a non-steroidal aromatase inhibitor (AI) used to lower circulating oestrogen levels in postmenopausal women with estrogen-responsive breast cancer. It is similar to exemestane, a steroidal AI, but its non-steroidal nature offers significant benefits, such as the absence of steroid-related side effects like weight gain and acne.
    1. Anastrozole Uses
    2. Anastrozole Side effects
    3. Precautions
    4. Interactions
    5. Dosage
    6. Storage
    7. Anastrozole vs Letrozole
    8. Frequently Asked Questions
    9. Citations

    Anastrozole Uses:

  • Anastrozole is used in conjunction with other therapies, such as surgery or radiation for the treatment of early breast cancer in postmenopausal women. This drug is also used as first-line therapy for breast cancer that has spread beyond the breast or to other parts of the body in women that have gone through menopause. The drug belongs to the class of drugs called nonsteroidal aromatase inhibitors. This works by reducing the amount of estrogen the body makes. The medication can slow or stop the growth of various types of breast cancer cells which need estrogen to grow.
  • Side Effects

  • Most common side effects of Anastrozole are:
    • Weakness
    • Weakness
    • Hot flashes
    • Sweating
    • Stomach pain
    • Nausea
    • Vomiting
    • Loss of appetitev
    • Constipation
    • Diarrhea
    • Heartburn
    • Weight gain
    • Muscle pain
    • Dizziness
    • Dry mouth
  • Some of the serious side effects of Anastrozole are:
    • Chest pain
    • Swelling and redness in the arm
    • Rash
    • Hives
    • Itching
    • Shortness of breath
    • Difficulty while swallowing or breathing
  • Anastrozole can cause some serious side effects and can lead to some serious health problems. Talk with your doctor if you are having any serious problems.
  • Precautions:

  • Before taking Anastrozole talk with your doctor if you are allergic to it or any other medication-related to it. The drug may contain some inactive ingredients which will cause serious allergic reactions or some other serious problems. Before using the drug talk with your doctor if you are having any medical history such as: Kidney disease, liver disease, heart disease, osteoporosis, high blood pressure and blood clots. The drug is primarily prescribed to women during menopause. This drug should not be used during pregnancy if you have not yet reached menopause. When taking this drug and for at least 3 weeks after stopping it, talk to your doctor about using a safe method of birth control (such as latex condoms).
  • How to use Anastrozole?:

  • Anastrozole should be taken orally and is usually taken once a day with or without food. Take the drug at around the same time every day. For getting benefited from this drug, take it on a daily basis. Take it at the same time every day to help you remember. Avoid increasing your dosage or try take this medication more often or for longer than recommended.
  • Dosage for breast cancer

  • Generic: Anastrozole
    • Form: oral tablet
    • Strengths: 1 mg
  • Brand: Arimidex
    • Form: oral tablet
    • Strengths: 1 mg
  • Adult dosage (ages 18 years and older): 1 mg tablet should be taken orally.
  • Missed Dose:

  • If you forget to take your dose, try to do so as soon as possible. If you only have a few hours until the next dose, only take one dose at that time. Never try to make up for missed doses by taking two at once. This could have dangerous consequences.
  • Overdose

  • If you take too much of this medication then it can cause some serious side effects like severe bleeding, death of tissues and gastritis. Talk with your doctor immediately if you are getting any adverse effects due to an overdose of these medications.
  • Interactions

  • Other drugs, vitamins, or herbs you may be taking may interact with an anastrozole oral tablet. When a substance alters the way a drug functions, this is known as interactions. This can be dangerous or impair the drug's effectiveness. To prevent drug reactions, your doctor should closely monitor all of your drugs. Make sure your doctor is aware of any medications, vitamins, or herbs you're using. Consult your doctor or pharmacist to learn how this medication can interact with other medications you're taking. The medications that interact with anastrozole are tamoxifen and estrogens.
  • Warnings for Serious Health Conditions

  • For people with osteoporosis: Anastrozole reduces oestrogen levels in the body, which can lead to brittle or thin bones. This could aggravate your osteoporosis and boost your risk of fractures even further. Before and during treatment with this medication, your doctor will check your bone mineral density.
  • For people with high cholesterol: This medicine has the potential to raise your cholesterol levels. This can improve the odds of having serious heart problems. When you're on anastrozole, the doctor will monitor your cholesterol levels.
  • For people with Heart Disease: The drug can cause low blood flow to your heart if you have a history of heart artery blockage. Discuss the dangers and benefits of taking this drug to treat your breast cancer with your doctor.
  • For pregnant women: Anastrozole is a pregnancy drug classified as category X. Drugs in the range X can never be used during pregnancy. If you're pregnant or about to become pregnant, tell your doctor. If you become pregnant while taking anastrozole, you should stop taking it immediately and contact your doctor.
  • Breastfeeding: Anastrozole does not tend to move by breast milk. If it does, it could have significant consequences for an infant who is breastfeeding. It's up to you and your doctor to determine whether you'll take the medication or breastfeed your infant.
  • Storage

  • Direct contact with heat, air and light may damage your medicines. Exposure to medicine may cause some harmful effects. The medicine must be kept in a safe place and out of children’s reach.
  • Mainly the drug should be kept at room temperature between 68ºF and 77ºF (20ºC and 25ºC).
  • Anastrozole vs Letrozole

    Anastrozole
    Letrozole
    Anastrozole is a prescription drug, available in the form of an oral tablet. This tablet is available as the brand name called Arimidex. Letrozole is an aromatase inhibitor that is used after surgery for the treatment of hormonally responsive breast cancer.
    Anastrozole is used in conjunction with other therapies, such as surgery or radiation for the treatment of early breast cancer in postmenopausal women. This medication is used to treat certain types of breast cancer in women after menopause (such as hormone-receptor-positive breast cancer). It is also used to help prevent cancer recurrence.
    Most common side effects of Anastrozole are:
    • Weakness
    • Headache
    • Hot flashes
    • Sweating
    Some of the common side effects of Letrozole are:
    • Nausea
    • Vomiting
    • Fatigue
    • Headache
    • Muscle aches

    Frequently Asked Questions:

    The drug belongs to the class of drugs called nonsteroidal aromatase inhibitors. This works by reducing the amount of estrogen the body makes. The medication can slow or stop the growth of various types of breast cancer cells.
    Most common side effects of Anastrozole are:
    • Weakness
    • Headache
    • Hot flashes
    • Sweating
    Arimidex reduces oestrogen levels rapidly, and certain side effects appear within 24 hours of beginning Arimidex. Hot flashes, nausea, vomiting, headaches, and pain are some of the more common side effects. After a few days or weeks, many of these will change.
    The drug is a chemotherapy regimen for the early stage of breast cancer.
    Anastrozole's estrogen-lowering effects may cause hair thinning or Grade 1 alopecia, although it is unlikely to cause total hair loss. Hair thinning caused by anastrozole typically improves after the first year, but some women may endure it for the rest of their care.
    Anastrozole is normally taken for five to ten years, depending on the specific circumstances. After years of taking the hormone therapy drug tamoxifen, some people begin taking anastrozole.

    Citations:

  • Anastrozole, https://link.springer.com/article/10.2165/00002512-199813040-00008
  • Combination Anastrozole and Fulvestrant in Metastatic Breast Cancer, https://www.nejm.org/doi/full/10.1056/nejmoa1201622