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Amiodarone

amiodarone

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By Medicover Hospitals / 11 Mar 2021
Home | Medicine | Amiodarone

What is Amiodarone?

  • Amiodarone is an antiarrhythmic medication that is used for treating and preventing irregular heartbeats. This includes ventricular tachycardia, ventricular fibrillation, wide complex tachycardia, atrial fibrillation, and paroxysmal supraventricular tachycardia.
    1. Amiodarone Uses
    2. Amiodarone Side effects
    3. Precautions
    4. Overdose
    5. Storage
    6. Amiodarone vs Metoprolol
    7. Frequently Asked Questions
    8. Citations

    Amiodarone Uses:

  • This medication is used for treating serious irregular heartbeats (such as persistent ventricular fibrillation or tachycardia). It is used to reestablish normal heart rhythm and keep the heartbeat regular and steady. It treats irregular heartbeats. It works by inhibiting certain electrical signals in the heart that cause irregular heartbeats.
  • How to use Amiodarone?

    • Before you begin using this, and each time you get a refill, read the Medication Guide provided by your pharmacist.
    • Take this medication orally once or twice daily, or as prescribed by your doctor. You may take this medication with or without food, but it is critical that you choose one method and use it consistently.
    • Unless otherwise directed by your doctor, avoid eating grapefruit or drinking grapefruit juice while taking this medication. Grapefruit has the potential to increase the concentration of this medication in your bloodstream.
    • The dosage is determined by your health condition as well as your response to therapy. Your doctor may advise you to begin taking this medication at a higher dose and start reducing it. Pay very close attention to your doctor's instructions. Do not discontinue or change the dosage of this medication without first talking to your doctor.

    Amiodarone Side Effects:

    • Nausea
    • Vomiting
    • Fatigue
    • Tremor
    • Lack of coordination
    • Constipation
    • Insomnia
    • Headache
    • Stomach pain
    • Uncontrollable or unusual movements of the body
    • Rash
    • Weight loss or gain
    • Restlessness
    • Weakness
    • Nervousness

    Precautions:

    • Tell your doctor or pharmacist if you are allergic to amiodarone, iodine, or if you have any other allergies before taking it. Inactive ingredients present in this product may cause some serious allergic reactions or some other problems.
    • Before taking this medication, inform your doctor or pharmacist about your medical history, particularly if you have: liver disease, lung disease, or thyroid problems.
    • Amiodarone has been linked to heart rhythm disorder (QT prolongation). QT prolongation may cause some serious (rarely fatal) fast/irregular heartbeat and other symptoms (such as severe dizziness and fainting) that require immediate medical attention.
    • Low potassium and magnesium levels in the blood may also increase your risk of QT prolongation. This risk may increase if you use certain medications (such as diuretics/water pills) or have conditions such as excessive sweating, diarrhea, or vomiting. Consult your doctor about how to use amiodarone safely.
    • Older adults may be more responsive to drug's side effects, particularly QT prolongation and thyroid problems.
    • Pregnant women should not take this drug unless it’s necessary. Before taking this drug, ask your doctor about all the complications and benefits. Based on your health condition, your doctor can recommend alternative medicine
    • This drug can pass into the breastmilk and can cause some serious problems to the newborn infant. Before taking the drugs, talk with your doctor if you are breastfeeding.

    Missed Dose:

  • If you forget to take one of the dosages, take it as soon as you remember. Skip the missed dose and proceed with your daily schedule. To cope up with a missed dose, do not take a double dose.
  • Overdose:

  • Overdose of a drug can be accidental. If you have taken more than the prescribed tablets there is a chance of getting a harmful effect on your body’s functions.
  • Storage:

  • Exposure of medicine to heat, air, and light may cause some harmful effects. The medicine must be kept in a safe place and out of children’s reach.
  • Amiodarone vs Metoprolol:

    Amiodarone
    Metoprolol
    Amiodarone is an antiarrhythmic medication that is used for treating and preventing a variety of irregular heartbeats Metoprolol belongs to the beta-blocker class of medications. The brand name is Lopressor; it is a selective 1 receptor blocker.
    It is used to treat and prevent certain types of severe, potentially fatal ventricular arrhythmias. It is used to treat high blood pressure, chest pain caused by poor blood flow to the heart, and a variety of conditions characterized by an abnormally fast heart rate
    Amiodarone mainly works by inhibiting potassium rectifier currents, which lead to heart repolarization during phase 3 of the cardiac action potential. It improves blood flow and lowers blood pressure by relaxing blood vessels and slowing heart rate.

    Frequently Asked Questions:

    It is used to treat and prevent certain types of serious, life-threatening ventricular arrhythmias (a type of abnormal heart rhythm) when other medications have failed to help or have been tolerated. Amiodarone belongs to the antiarrhythmic medication class.
    It causes blood vessels to dilate (enlarge). Blood pressure may fall as a result of this effect. As a result of this effect, it may also be beneficial in patients with congestive heart failure.
    This medication must be taken on a consistent basis for one to three weeks before a response is seen, and for several months before the full effect is felt. Because of the drug's long half-life, it can stay in your system for up to two months
    It should be used only if you have a potentially fatal arrhythmia or irregular heart rate. This medication may cause serious side effects. These include serious lung issues, liver issues, and a worsening of your irregular heart rate.
    It has been linked to a number of systemic side effects, including bradycardia, hypothyroidism or hyperthyroidism, pulmonary toxicity, ocular deposits, and liver function abnormalities.
    It can interact with statins such as simvastatin, atorvastatin, and lovastatin, increasing the risk of severe muscle breakdown, kidney failure, or liver disease.
    If you are allergic to this medicine or iodine, or if you have any kind of serious heart condition called AV block (2nd or 3rd degree), unless you have a pacemaker; a history of fainting, or if your heart cannot pump blood properly, you should not use this medicine.
    Due to the health risks of untreated arrhythmias, patients should not discontinue amiodarone, a heart medication, without doctor supervision.
    The treatment is associated with an increased risk of stroke in patients with AF, particularly in those who had a low risk of stroke at the start. Antiplatelet drugs and warfarin may reduce the risk of stroke in amiodarone-treated patients.

    Citations:

  • Amiodarone, https://www.nejm.org/doi/pdf/10.1056/NEJM198702193160807
  • Amiodarone for Thyroid, https://www.sciencedirect.com/science/article/abs/pii/S0002934305002196