By Medicover Hospitals / 16 Feb 2021
What is Amikacin?
Amikacin is an antibiotic used for many types of bacterial infections. These include joint infections, intra-abdominal infections, meningitis, pneumonia, sepsis, and urinary tract infections. It is also used in the treatment of multidrug-resistant tuberculosis.
- Amikacin Uses
- Amikacin Side effects
- Amikacin Interactions
- Amikacin Overdose
- Amikacin Storage
- Amikacin vs Gentamicin
- Frequently Asked Questions
This medicine is used to prevent or treat a wide range of bacterial infections. Amikacin is a class of drugs known as aminoglycoside antibiotics. It works by stopping the growth of bacteria.
How to use Amikacin sulfate vial
This medication is given through injection into the veins or muscles. It's usually given every 8 hours or as directed by your doctor. The dosage is based on your medical condition, weight, and response to your treatment. Laboratory tests (such as kidney function, blood drug levels) may be performed to help you find the best dose for your condition.
If you give this medicine to yourself at home, learn all the instructions for preparation and use from your health care professional. Check this product package visually for any particles or discoloration before usage. Do not use this liquid if either is there. Know how to store and dispose of medical supplies safely.
Use this antibiotic at evenly spaced intervals of time for the best result. Remember to use this medication at the same time every day.
Continue to use this medicine until the prescribed amount is complete, even if the symptoms disappear after a few days. Stopping the medication early before the dosage is completed may allow bacteria to continue to grow, which may lead to a recurrence of the infection.
Amikacin Side Effects:
- Black, tarry stools
- Bloody or cloudy urine
- Bluish lips or skin
- Blurred vision
- Pins and needles
- Tingling feelings
- Chest pain
- The decrease in the amount of urine
- Decreased urine output
- Difficulty with breathing
- Difficulty with moving
- Faintness or lightheadedness
- Dry mouth
- The feeling of fullness in the ears
- Hearing loss
- Loss of balance
- Loss or change in hearing
- Muscle pain or stiffness
- Muscle twitching
- Not breathing
- Pain in the joints
- Pain in the lower back or side
- Painful or difficult urination
- Pale skin
- Rapid weight gain
- Ringing or buzzing in the ears
- Shortness of breath
- Sore throat
- White spots on the mouth
- Swelling of the face, ankles, or hands
- Swollen glands
- Trembling or shaking of the hands
- Trouble with hearing
- Troubled breathing with exertion
- Unusual bleeding or bruising
- Unusual tiredness or weakness
Inform your doctor if you are allergic to amikacin, or to other aminoglycoside antibiotics (such as tobramycin or gentamicin); or if you have any other allergies. This product may contain inactive ingredients (such as sulfites) that may cause allergic reactions or other problems.
Before using this medicine, tell your doctor or pharmacist your medical history, in particular: cystic fibrosis, hearing problems (including hearing loss), kidney problems, low blood minerals (including potassium, magnesium, calcium), myasthenia gravis, Parkinson's disease.
Amikacin may cause live bacterial vaccines (such as the typhoid vaccine) to fail to work as well. Do not have any immunizations/vaccinations while using this medicine unless your doctor tells you to do so.
Older adults may be more sensitive to the effects of this drug, particularly kidney damage.This medicine is not recommended for use during pregnancy. Although there have been reports of harm in infants born to women using similar drugs, there have been no reports of harm in infants born to women using amikacin. Discuss the risks and benefits.
This drug is passed into small amounts of breast milk. However, many doctors consider breastfeeding safe while taking this medicine. Consult your doctor before you breast-feed.
Drug interactions might change the way your drugs work or increase the risks of serious side effects. Keep a list record of all the products you use and share them with your doctor and pharmacist. Do not suddenly start, stop or change the dosage of any medicine without your doctor's approval.
Other drugs that may affect the kidneys or the hearing may increase the risk of kidney damage or hearing loss if taken with amikacin.
Do not take extra doses of this medicine. It might cause you something serious, immediately contact a doctor.
If you forget to take any dose, take it at the time remember but never take two doses at once.
Please refer to the product instructions and your pharmacist for storage details. Keep all drugs away from pets and children. Do not flush the medication down the toilet or pour it into the sink unless instructed to do so. Discard this product properly when it has expired or is no longer needed. Consult your pharmacist about the local waste disposal company.
Amikacin vs Gentamicin:
|Amikacin is an antibiotic medication
||Gentamicin is an antibiotic medication
|Molecular Formula: C22H43N5O13
|Molar mass: 585.6 g/mol
||Molecular Formula: C21H43N5O7
|This medicine is used to prevent or treat a wide range of bacterial infections.
||Gentamicin used to treat several types of bacterial infections
|Amikacin injection is from the class of medications called aminoglycoside antibiotics.
||Drug Class: Aminoglycoside antibiotic
Frequently Asked Questions:
Staphylococcus and Nocardia are the only Gram-positive bacteria that are strongly affected by amikacin. Amikacin may also be used to treat non-tuberculous mycobacterial infections and tuberculosis (if caused by sensitive strains) when first-line drugs fail to control the infection.
Amikacin therapy is administered once a day to outpatients and it may be a feasible treatment option for mild to moderate urinary tract infections caused by ESBL-EC, in cases of adverse drug reactions to carbapenem, or in places with limited resources, provided that patients are closely monitored for renal function.
Amikacin injection is used for the treatment of certain serious infections caused by bacteria such as meningitis (membrane-surrounding infection of the spinal cord and brain) and infections of the blood, abdomen (stomach area), bones, lungs, joints, skin, and urinary tract.
Amikacin sulfate injection is given intravenously or intramuscularly. Amikacin should not be physically premixed with any other medicinal drugs but should be administered separately based on the recommended dose and route. The patient's pretreatment body weight should be obtained for the correct dosage calculation.
Amikacin is a highly effective amino-glycoside, highly effective against extended-spectrum beta-lactamase (ESBL) bacteria. Older patients suffer from more urinary tract infections (UTIs) and have a higher frequency of infections with resistant bacteria, especially among frail nursing home residents.
Once-daily amikacin was shown to kill more than 8 h higher than all other drugs administered as monotherapy for both strains tested (P < 0.01). Regrowth by 24 h was greatest for the amikacin regimen (P < 0.01) but was evident for all monotherapy regimens against both strains.
The plasma elimination half-life of amikacin in adults with normal renal function is usually 2-3 hours. 94-98 percent of a single IM or IV amikacin dose is excreted unchanged by glomerular filtration within 24 hours.
To minimize the risk of nephrotoxicity, select the loading and maintenance of aminoglycoside doses based on the estimated creatinine clearance. Also, monitor peak and trough serum aminoglycoside levels, restore volume, and correct potassium and magnesium abnormalities
Amikacin is commonly used as an antibacterial drug that can cause significant nephrotoxic effects in humans and experimental animals. One mechanism of the toxic effects of aminoglycoside antibiotics has been reported to be the result of oxidative reactions.
The usual duration of treatment is between 7 and 10 days. It is desirable to limit the duration of treatment to the short term, whenever possible. The total daily dose for all routes of administration should not exceed 15 mg/kg/day.