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By Dr.Rajesh Bollapragada
Consultant Physician
What is a Globulin Test? Why do I need a globulin test? What happens during a globulin test? What do the results mean? Faqs

Globulin Test

What is a Globulin Test?

Globulins are proteins found in the blood. The immune system creates them in the liver. Globulins are crucial for liver function, blood clotting, and infection resistance.

Total protein test:

This test determines globulin and albumin protein in the blood. Low protein levels may indicate liver or kidney disease.

Serum protein electrophoresis:

This blood test determines the concentration of each type of protein in the blood, including Gamma globulins. The levels of specific globulins indicate how well the immune system works. As a result, this test can be used to diagnose multiple myeloma, and various other conditions.

What is the globulin test used for?

Globulin testing can help with the diagnosis of various diseases, including:

Why do I need a globulin test?

The doctor may prescribe globulin tests in the following conditions:

  • As part of the routine examination
  • To keep track of any liver or kidney issues.
  • When you experience specific symptoms that are globulin test related.

A comprehensive metabolic panel, which is often a component of a standard examination, may include a total protein test. If you exhibit kidney or liver disease signs, the doctor might recommend the test.


A total protein test may be performed together with other tests to evaluate how well the liver is functioning if the doctor suspects a liver problem. They are known as liver function tests. The doctor may prescribe these tests if you have any of the following symptoms or are at risk for liver disease:


A serum protein electrophoresis test determines the concentrations of several globulin subtypes and other proteins in the blood. This test may be prescribed by the doctor to identify problems with the immune system, such as:

What happens during a globulin test?

Globulin testing is similar to blood tests. A blood test involves a healthcare provider taking blood from a vein in the arm with a small needle. After the insertion of the needle, a small amount of blood will be collected in a test tube or vial. One may feel a slight sting when the needle goes in or out. This normally takes under five minutes.

How to prepare for the globulin test?

A globulin blood test does not require any extra preparation. However, if the doctor has requested further tests on the blood sample, people may need to fast for hours before the test.

Are there any risks involved in the test?

A blood test poses no risk. Some people may experience pain or bruises where the needle was inserted, but most of these symptoms will go away shortly.

What do the results mean?

Low globulin levels may indicate liver or renal illness, as well as malnutrition. High globulin levels may indicate:

  • Inflammatory disease
  • Infection
  • Immune disorders
  • Certain cancers, such as malignant lymphoma, multiple myeloma, or Hodgkin lymphoma

Certain medications, dehydration, or other conditions can also cause abnormal readings.

Frequently Asked Questions

1. What is the normal globulin level?

The normal value of globulin levels: Serum globulin: 20-35 grams per liter (g/L)or 2.0 to 3.5 grams per deciliter (g/dL)

2. What does it mean if the globulin is low?

If globulin levels fall below this normal range, it can indicate a number of serious health problems. Low globulin levels can be caused by renal disease, hepatic dysfunction, celiac disease, inflammatory bowel disease (IBD), and acute hemolytic anemia.

3. Why is the globulin test important?

Protein levels in the blood are measured by globulin blood tests. High levels could indicate an autoimmune condition, infection, or malignancy. A low globulin level could indicate liver or kidney illness.

4. Can low globulin be treated?

Eating lean protein, such as fish, can help raise total protein levels and treat low globulin. It may also be beneficial to boost the consumption of foods that aid liver and kidney detoxification.

5. What are the other names for the globulin test?

Serum electrophoresis is the name given to the globulin test. It is a blood test that determines the concentrations of four different types of globulins.

6. Does stress increase globulin?

Gamma-globulin levels declined after the first stress exposure but it increases after subsequent exposures.

7. Does high globulin mean diabetes?

Diabetes risk has also been linked to elevated globulin levels.

8. Can dehydration cause high globulins?

Yes, dehydration can have an impact on globulin levels. When people are dehydrated, their globulin levels rise.

9. Does pregnancy affect globulin levels?

Yes, globulin levels are higher in pregnant women. Total protein levels rise during pregnancy and then return to normal after childbirth. This variation is normal and usually not cause for concern.

10. What is the cost of the globulin test?

The cost of the globulin test is approximately Rs. 160- Rs. 300.