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By Medicover Hospitals / 15 Feb 2021
Home | Medicine | serrapeptase

What is Serrapeptase

  • Serrapeptase is an enzyme isolated from bacteria present in silkworms. It has been used for years in Japan and Europe to reduce inflammation and pain due to surgery, trauma, and other inflammatory conditions. Serrapeptase is now widely available as a dietary supplement and has many purported health benefits.
  • Serrapeptase—also known as serratiopeptidase—is a proteolytic enzyme that breaks down proteins into smaller components called amino acids. It is produced by bacteria in the digestive tract of silkworms and allows the emerging moth to digest and dissolve its cocoon. The use of proteolytic enzymes such as trypsin, chymotrypsin, and bromelain was put into practice in the United States in the 1950s after anti-inflammatory effects were observed. The same observation was made with serrapeptase in Japan at the end of the 1960s when researchers initially isolated the enzyme from the silkworm. In fact, researchers in Europe and Japan have suggested that serrapeptase should be the
    1. Serrapeptase Uses
    2. Benefits
    3. Serrapeptase Side effects
    4. Precautions
    5. Dosage
    6. Frequently Asked Questions
    7. Citations

    Serrapeptase Uses:

    • Bony and pain in the joints (osteoarthritis, rheumatoid arthritis, osteoporosis, fibromyalgia)
    • Headaches (migraine, tension headache)
    • Inflammation of the sinuses, pharynxes and sinuses
    • Infections of the ear (otitis media)
    • Blood clots
    • Postoperative injury or traumatic swelling
    • Syndrome of Carpal Tunnel
    • Following dental extraction
    • Chronic diseases of the airway (bronchitis)
    • Ulcer and inflammation of the colon (ulcerative colitis)
    • Blood clots (thrombophlebitis)
    • Mammary Fibrocystic Disease


    Reduces inflammation

  • Serrapeptase is most commonly used to reduce inflammation—the response of your body to injury. In dentistry, the enzyme was used following minor surgical procedures—such as tooth removal—to reduce pain, lockjaw (jaw muscle spasm) and facial swelling. Serrapeptase is thought to decrease inflammatory cells in the affected site. One review of five studies aimed at identifying and confirming the anti-inflammatory effects of serrapeptase compared to other drugs following the surgical removal of wisdom teeth. Researchers concluded that serrapeptase was more effective in improving lockjaw than ibuprofen and corticosteroids, potent drugs that tame inflammation. What's more, although corticosteroids were found to outperform serrapeptase by reducing facial swelling on the day after surgery, the differences between the two later were insignificant. However, due to a lack of eligible studies, no pain analysis could be performed. In the same study, researchers also concluded that serrapeptase has a better safety profile than other drugs used in the analysis—suggesting that it could serve as an alternative in cases of intolerance or adverse side effects to other drugs.
  • Reduces infections

  • Serrapeptase may reduce your risk of bacterial infections. In a so-called biofilm, bacteria can unite to form a protective barrier around their group. This biofilm acts as a shield against antibiotics, enabling bacteria to grow rapidly and cause infection. Serrapeptase inhibits the formation of biofilms, increasing the efficacy of antibiotics. Research has suggested that serrapeptase improves the efficacy of antibiotics in the treatment of Staphylococcus aureus (S. aureus), the leading cause of health-related infections. In fact, test tubes and animal studies have shown that antibiotics are more effective when combined with serrapeptase in the treatment of S. Aureus than antibiotic therapy alone. Furthermore, the combination of serrapeptase and antibiotics was also effective in the treatment of infections that had become resistant to the effects of antibiotics. Several other studies and reviews have suggested that serrapeptase in combination with antibiotics may be a good strategy for reducing or stopping the progression of infection—especially from antibiotic-resistant bacteria.
  • Dissolves blod clot

  • Serrapeptase may be beneficial in the treatment of atherosclerosis, a condition where plaque builds up inside your arteries. It is thought to act by breaking down dead or damaged tissue and fibrin—a tough protein formed in blood clots. This may allow serrapeptase to dissolve plaque in your arteries or dissolve blood clots that may lead to stroke or heart attack. Much of the information on its ability to dissolve blood clots, however, is based on personal stories rather than facts. More research is therefore needed to determine the role—if any—of serrapeptase in the treatment of blood clots.
  • Serrapeptase Side effects

    • Allergic reactions
    • Rash
    • Fever
    • Stomach ache
    • Bleeding in patients of bleeding disorders
    • Nausea
    • Weakness
    • Dizziness
    • Drowsiness
    • Itchiness


  • Surgery: Serrapeptase may interfere with blood clotting. There is concern that bleeding may increase during and after surgery. Stop using serrapeptase at least 2 weeks before surgery is scheduled.
  • Pregnancy and breast-feeding: There is not enough information about the use of serrapeptase during pregnancy and breast-feeding. Stay on the safe side and avoid using it.
  • Bleeding disorders: Serrapeptase may interfere with blood clotting, so some researchers are concerned that it may make bleeding disorders worse. If you have a bleeding disorder, check with your health care provider before taking serrapeptase.
  • Dosage

  • When taken orally, serrapeptase is easily destroyed and deactivated by stomach acid before it has a chance of getting absorbed into your intestines.
  • For this reason, dietary supplements containing serrapeptase should be energetic-coated, preventing them from dissolving in the stomach and allowing for intestinal release.
  • Doses typically used in studies range from 10 mg to 60 mg daily.
  • Serrapeptase enzymatic activity is measured in units of 10 mg equal to 20,000 units of enzyme activity.
  • You should take it on an empty stomach or at least two hours before you eat. In addition, after taking serrapeptase, you should avoid eating for about half an hour.
  • Frequently Asked Questions:

    Serratiopeptidase is a proteolytic enzyme used to reduce inflammation and has anti-epidemic, analgesic, fibrinolytic and caesinolytic properties.
    Serrapeptase enzymatic activity is measured in units of 10 mg equal to 20,000 units of enzyme activity. You should take it on an empty stomach or at least two hours before you eat. In addition, after taking serrapeptase, avoid eating for about half an hour.
    Two different classes of drugs, serratiopeptidase, an anti-inflammatory proteolytic enzyme, and dexamethasone, a long-acting corticosteroid with a minimum or zero mineralocorticoid activity having a maximum anti-inflammatory effect, were evaluated for its efficacy and compared to each other for its ability to act.
    Serrapeptase appears to be safe for adults when taken by mouth, in the short term (up to 4 weeks). The long-term safety of serrapeptase is unknown.
    I still have very little lung build-up today. Serrapeptase is a blood cleaner so it may help to reduce BP slightly, but it is not a blood thinner. After 8/9 months the side benefit is that many of my capillary varicose veins in my legs are gone because of the serra.
    Serratiopeptidase reduces pain and swelling without inhibiting prostaglandin and has no adverse gastrointestinal effects. It also works by enhancing blood circulation due to proteolytic effects, removing damaged and denatured proteins and cell debris, and modulating inflammatory cytokines.
    The usual adult dose of serrapeptase is 10 mg 3 times daily (range 15 to 60 mg/day) 2 hours after meals. Serrapeptase has been used as an anti-inflammatory agent for 1 to 2 weeks and as a mucolytic agent for up to 4 weeks.
    Elimination of excessive inflammation with potent (serratiopeptidase-containing) systemic enzyme formulations may reduce the size of fibroids by limiting the vascularization of fibroids and by enzymatic fibroid myolysis.
    No matter the cause or location (even the blood brain barrier), Serrapeptase works to stop the inflammation. If this is not enough, it has the ability to dissolve any dead or non-living tissue that may be gumming, particularly mucus and pain-related inflammation.


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