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Hydrochlorothiazide is a prescription drug which comes in the form of tablet and capsules. The most widely prescribed thiazide diuretic is hydrochlorothiazide. It is suggested that edema and hypertension should be treated. Hydrochlorothiazide and angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers are present in several combination products.

Hydrochlorothiazide Uses

Hydrochlorothiazide is used to treat heart failure, cirrhosis, chronic kidney failure, corticosteroid drugs, and nephrotic syndrome caused by excessive fluid accumulation and swelling (edema) in the body. It is also used to treat elevated blood pressure alone or in combination with other blood pressure reducing drugs. Hydrochlorothiazide can be used to treat kidney stones containing calcium because it reduces the amount of calcium excreted in the urine by the kidneys and thereby reduces the amount of stone-forming calcium in the urine.

For the management of high blood pressure, this drug is used. Lowering high blood pressure helps to avoid strokes, kidney complications, and heart attacks. Hydrochlorothiazide belongs to a class of drugs known as water pills/diuretics. It works by causing more urine to be made. This helps get rid of excess salt and water from your body.

Hydrochlorothiazide Side effects

Some of the common side effects of Hydrochlorothiazide are:

  • Blood pressure
  • Dizziness
  • Headache
  • Weakness
  • Erectile Dysfunction
  • Tingling in the hands, legs and feet

Some of the serious side effects of Hydrochlorothiazide are:

  • Painful skin rash
  • Skin peeling and blisters
  • Fever
  • Mouth sores
  • Weakness
  • Abnormal heart rate
  • Eye pain

If you have any of these serious symptoms immediately contact your doctor for further assistance. In any case, due to Hydrochlorothiazide if you get any kind of reactions in your body try avoiding it.

Precautions

Before taking Hydrochlorothiazide talk with your doctor if you are allergic to it or any other medications. The product may contain some inactive ingredients which can cause some serious allergic reactions or some other serious problems. Before taking Hydrochlorothiazide talk with your doctor if you are having any medical history such as: Diabetes, Gout, Kidney disease, Liver disease, Lupus and skin cancer.

Dosage

Hydrochlorothiazide Dosage, Forms and strengths

Generic: Hydrochlorothiazide

Form: oral tablet (12.5 mg, 25 mg, and 50 mg)

Adult dosage (ages 18 to 64 years)

Typical starting dosage: 25 mg taken orally once a day.

Dosage for Edema

Adult dosage (ages 18 to 64 years)

Typical dosage: 25 to 100 mg taken orally every day

Missed Dose

If a dose is missing, take it as soon as you recall it. If the time for the next dose is close, skip the skipped dose. At your normal time, take your next dose. To catch up, do not double the dose.

Overdose

Overdose of a drug can be accidental. If you have taken more than the prescribed Hydrochlorothiazide tablets there is a chance of getting a harmful effect on your body’s functions. Overdose of a medicine can lead to some medical emergency.

Warnings for Some Serious Health Conditions

For People with Kidney Problems

If you have impaired kidney function, use caution when taking hydrochlorothiazide. Your kidneys clean this substance from your body. This drug can build up in your body and cause more side effects if your kidneys don't work as well. Your doctor could stop your treatment with this drug if your kidney function gets worse.

For people with liver problems

When you have a low liver function or progressive liver disease, use this medicine with caution. Hydrochlorothiazide can cause an imbalance of electrolytes and fluids. This will exacerbate your liver function.

For women who are Pregnan

If you're pregnant or planning to become pregnant, speak to your doctor. Animal experiments do not always predict how human beings will react. Therefore, if specifically needed, this medication should only be used in pregnancy.

For women who are Breastfeeding

In a child who is breast-feeding, hydrochlorothiazide can transfer into breast milk and can cause side effects. If you're breastfeeding your infant, speak to your doctor.

Storage

  • Store hydrochlorothiazide at a temperature of 20 °C to 25 °C (68 °F to 77 °F).
  • Keep hydrochlorothiazide away from the sunlight.
  • Do not store this drug in places, such as toilets, that are cold or damp.

Hydrochlorothiazide Vs Chlorthalidone

Hydrochlorothiazide

Chlorthalidone
Hydrochlorothiazide is a prescription drug which comes in the form of tablet and capsules. The most widely prescribed thiazide diuretic is hydrochlorothiazide. Chlorthalidone is a medicine that is used to treat high blood pressure (hypertension). High blood pressure reduction helps prevent strokes, heart attacks and problems with the kidneys.
Hydrochlorothiazide is used to treat heart failure, cirrhosis, chronic kidney failure, corticosteroid drugs, and nephrotic syndrome caused by excessive fluid accumulation and swelling (edema) in the body Chlorthalidone, a 'water pill,' is used to treat various conditions, including heart disease, that cause high blood pressure and fluid retention.
Some of the common side effects of Hydrochlorothiazide are:
  • Blood pressure
  • Dizziness
  • Headache
  • Weakness
 Some of the common side effects of Folic acid are:
  • Diarrhea
  • Loss of appetite
  • Hives
  • Rash
  • Itching

Citations

Hydrochlorothiazide, https://link.springer.com/article/10.1007/BF00607430
Effects of Hydrochlorothiazide, https://www.nejm.org/doi/full/10.1056/NEJM198909283211305

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Frequently Asked Questions

What is hydrochlorothiazide used for?

Hydrochlorothiazide is used to treat edema caused by various medical conditions, including heart, kidney, and liver disease (fluid retention; excess fluid retained in body tissues), and to treat edema caused by the use of some drugs, including estrogen and corticosteroids.

Does hydrochlorothiazide make you lose weight?

Hydrochlorothiazide (Microzide) acts in the body to get rid of excess fluid. It can cause weight loss by getting rid of this fluid. Bear in mind that this is not fat loss, but water weight.

What is the best time of day to take hydrochlorothiazide?

Take this medicine by mouth as prescribed by your doctor, usually once a day with or without food in the morning. You will need to get up to urinate if you are taking this medication too close to bedtime. At least 4 hours before bedtime, it is best to take this drug.

Who should not take hydrochlorothiazide?

Tell your doctor whether you have liver failure, kidney disease, glaucoma, asthma or allergies, gout, diabetes, or whether you are allergic to sulfa medications or penicillin before using hydrochlorothiazide.

What are the most common side effects of hydrochlorothiazide?

Some of the common side effects of Hydrochlorothiazide are:

  • Reduce in the number of white blood cells
  • Bruising and bleeding
  • Anaemia (low number of red blood cells)
  • Feeling sick
  • Loss of appetite
  • Effects the kidneys
  • Changes in hearing.

Disclaimer: The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not be treated as a replacement for physical medical consultation or advice. We do not guarantee the accuracy and the completeness of the information so provided. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company. We do not take any responsibility for the consequences arising out of the aforementioned information and strongly recommend you for a physical consultation in case of any queries or doubts.