Dexedrine is a central nervous system stimulant primarily used to manage Attention Deficit Hyperactivity Disorder (ADHD) and narcolepsy. It helps improve focus and attention while reducing impulsiveness and hyperactivity in individuals with ADHD

What is Dexedrine?

Dexedrine Tablet is the brand name for a drug that consists entirely of dextroamphetamine. Available in tablet form and as Dexedrine Spansule capsules, it is a central nervous system stimulant used to treat Attention Deficit Hyperactivity Disorder (ADHD).

In patients with ADHD, it may help increase attention while decreasing impulsiveness and hyperactivity.

What Are the Uses of Dexedrine?

Dexedrine is primarily used to treat ADHD and narcolepsy, offering benefits such as improved attention and wakefulness.

Conditions Dexedrine Treats

  • ADHD: Dexedrine helps individuals with ADHD by improving their ability to pay attention, focus, and manage behavioral issues.
  • Narcolepsy: For those with sleeping disorders like narcolepsy, Dexedrine helps them stay awake during the day. It is not recommended for general tiredness.

Secondary Uses of Dexedrine

While primarily for ADHD and narcolepsy, dextroamphetamine, the active ingredient in Dexedrine, has also been studied for other uses, though these are less common or off-label.

How Do Dexedrine Tablets Work?

Dexedrine works as a central nervous system stimulant by affecting certain natural substances in the brain.

The mechanism of action of amphetamines like dextroamphetamine involves increasing the release and blocking the reuptake of neurotransmitters such as dopamine and norepinephrine in the brain.

This action helps to improve communication between brain cells, leading to increased attention and decreased impulsivity and hyperactivity.

How to Use

Dexedrine comes in liquid, tablet, and extended-release capsule forms:

  • Dexedrine Tablets: Usually taken twice daily, with or without food.
  • Dexedrine capsules (extended-release): Typically taken once daily, with or without food.
  • Liquid: Typically consumed once or twice daily, with or without food.

Administration Tips

  • Take the first dose in the morning and space subsequent doses 4 to 6 hours apart.
  • Avoid taking it in the evening to prevent sleep disturbances.
  • Start with a low dose and gradually increase as prescribed by your doctor.

Dexedrine Dosage

Dexedrine Tablet dosage varies based on individual needs and medical conditions. Always follow a doctor's guidance for safe use.

Typical Dosage Instructions:

Age Group / Condition Initial Dose Titration / Max Dose Notes
Adults - ADHD (IR) 5mg once or twice daily Increase by 5mg/week; rarely exceed 40mg/day Doses 4 -6hrs apart; avoid late dosing
Adults - ADHD (ER/Spansule) 5mg once daily (morning) Increase by 5mg/week; max ~40mg/day (may reach 60mg in select cases) Oncedaily extended release
Adults - Narcolepsy 10mg once daily (morning) Increase by 10mg/week; usual range 5 -60mg/day in divided doses Divide 1 -3 doses/day; avoid evening dose
Children 3 -5yrs - ADHD 2.5mg once daily (IR) Increase by 2.5mg/week; seldom exceed 40mg/day Limited efficacy/safety data in this group
Children ≥6yrs - ADHD (IR) 5mg once or twice daily Increase by 5mg/week; max ~40mg/day Divide doses 4 -6hrs apart
Children ≥6yrs - ADHD (ER/Spansule) 5mg once daily (morning) Increase by 5mg/week; max ~40mg/day (up to 60mg if >50kg) Oncedaily extended release
Children 6 -11yrs - Narcolepsy 5mg once daily Increase by 5mg/week; up to ~60mg/day Use IR or ER; avoid evening dosing
Adolescents ≥12yrs - Narcolepsy 10mg once daily Increase by 10mg/week; up to ~60mg/day Divide into 1 -3 doses/day
Geriatric - Narcolepsy 5mg once daily Increase by 5mg/week; max ~60mg/day Start low and go slow; monitor closely

What Should I Do If I Miss a Dose?

If you miss a dose of Dexedrine, take it as soon as you remember. Skip it if it's close to your next dose, and never double the dose to make up for a missed one.

What Happens If I Overdose?

An overdose of Dexedrine can be dangerous and harm bodily functions. Seek immediate medical attention if you suspect an overdose.

Symptoms of Overdose

  • Restlessness
  • Rapid breathing
  • Confusion
  • Tremors
  • Fever

What to Avoid

  • Avoid taking Dexedrine in the evening to prevent sleep disturbances.
  • Do not consume alcohol, as it may worsen Dexedrine side effects.

Key Dosage Tip: Follow your doctor's instructions carefully. Proper timing and dosage prevent complications.

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What Are the Side Effects of Dexedrine?

Dexedrine, like any medication, may cause side effects, ranging from mild to severe. Most people tolerate it well, but awareness is key.

Common Side Effects

  • Headache
  • Dry mouth
  • Unpleasant taste
  • Constipation
  • Weight loss
  • Excessive tiredness

Serious side effects include:

  • Slow or difficult speech
  • Dizziness
  • Weakness
  • Numbness of an arm or leg
  • Seizures
  • Mood changes
  • Hallucinations
  • Vision changes
  • Hives
  • Paleness

Precautions and Warnings

Specific individuals should exercise caution or avoid Dexedrine due to potential health risks or interactions.

Who Should Avoid Dexedrine

  • People with heart problems or high blood pressure.
  • Those with a history of substance abuse.

Conditions Where Caution Is Needed

  • Anxiety or mental health disorders.
  • Thyroid issues or glaucoma.
  • Pregnancy: Not recommended; can cause complications for the baby.
  • Breastfeeding: Not advised as the drug can pass into breast milk.

Are There Any Age Restrictions for Using Dexedrine?

  • Children: May experience weight loss or growth suppression; regular monitoring is needed.
  • Older Adults: More prone to severe Dexedrine side effects, like heart issues.

Alcohol or Food Interactions:

  • Avoid alcohol, as it can increase side effects.
  • No specific food restrictions, but take with or without food as advised.

Key Precaution: Dexedrine isn't safe for everyone. Discuss your medical history with your doctor.

Possible Interactions with Other Medications (Drug Interactions)

Dexedrine can interact with other medications or supplements, potentially causing adverse effects. Always inform your doctor about all products you use.

  • Medications to Avoid: MAO inhibitors can cause serious, potentially life-threatening interactions.
  • Other Interactions: Cough-and-cold products or diet aids may increase risks.
  • Supplements and Herbal Products: Some herbal products, like St. John's Wort, may affect Dexedrine's effectiveness.

Key Interaction Note: Share your medication list with your doctor. This prevents harmful drug interactions.

How Should Dexedrine Be Stored?

Proper storage ensures Dexedrine remains effective and safe. Keep it in a secure, controlled environment.

Recommended Storage Temperature for Dexedrine

  • Store at room temperature, between 68°F and 77°F (20°C to 25°C).
  • Keep Dexedrine capsules, tablets, or liquid away from heat, moisture, and direct sunlight.

What Happens If Dexedrine Is Not Stored Properly?

Improper storage may reduce the medication's effectiveness or make it unsafe to use.

Keep Away from Children, Sunlight, or Moisture

  • Store in a locked cabinet, out of children's reach.
  • Avoid bathrooms or areas with high humidity.

Dexedrine vs Adderall

Dexedrine Adderall
Contains only dextroamphetamine. Contains a combination of amphetamine and dextroamphetamine.
Used to treat ADHD, improve focus, and manage behavioral issues. Treats hyperactivity and controls impulses.
Modifies concentrations of natural substances in the brain. Enhances the effects of neurotransmitters like dopamine and norepinephrine.

References

BENZEDRINE and DEXEDRINE in the Treatment of Children's Behavior Disorders | Pediatrics
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Frequently Asked Questions

Yes, Dexedrine is a Schedule II controlled substance due to its high potential for abuse, which can lead to tolerance, psychological dependence, and severe social disability.

Dexedrine increases dopamine and norepinephrine activity in the brain, stimulating areas that control attention and movement to alleviate ADHD and narcolepsy symptoms.

Yes, Dexedrine is a central nervous system stimulant approved for treating ADHD and narcolepsy, a condition causing severe daytime drowsiness.

Dexedrine contains only the most potent form of amphetamine, while Adderall combines two active forms. Responses vary, but most people with ADHD react similarly to both.

Dexedrine boosts dopamine and norepinephrine, enhancing focus and potentially causing pleasurable feelings due to its effect on the brain's reward system.

As a stimulant, Dexedrine typically starts working within 30 minutes to an hour. Its short-acting tablets have a half-life of four to six hours.

Yes, Dexedrine can cause weight loss by reducing appetite and increasing calorie burning. It is sometimes used to treat binge eating or aid weight loss.

A 5mg Dexedrine pill contains dextroamphetamine, a stimulant used to treat ADHD (attention deficit hyperactivity disorder) and narcolepsy. It helps improve focus, attention, and alertness by increasing certain brain chemicals like dopamine.

In India, Dexedrine (dextroamphetamine) is not commonly available under the same brand name. It is a controlled substance and is not widely marketed due to strict regulations around stimulant medications. If prescribed, doctors may use alternatives like methylphenidate (available as Concerta, Addwize, or Intuniv) for ADHD.


Disclaimer: The information provided is accurate and up-to-date to the best of our knowledge. However, it should not be considered a substitute for medical advice or consultation. We do not guarantee its completeness or accuracy. The absence of specific warnings does not mean a medicine is safe for all users. We are not responsible for any outcomes based on this information and strongly recommend consulting a doctor for any medical concerns or questions.

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