Dexedrine Tablet: How It Works, Uses, and Side Effects.
Written by Medicover Team and Medically Reviewed by Dr Pavan Kumar Rudrabhatla, Neurology
Dexedrine is a central nervous system stimulant primarily used to manage Attention Deficit Hyperactivity Disorder (ADHD) and narcolepsy. It helps improve focus and attention while reducing impulsiveness and hyperactivity in individuals with ADHD
Dexedrine Tablet is the brand name for a drug that consists entirely of dextroamphetamine. Available in tablet form and as Dexedrine Spansule capsules, it is a central nervous system stimulant used to treat Attention Deficit Hyperactivity Disorder (ADHD).
In patients with ADHD, it may help increase attention while decreasing impulsiveness and hyperactivity.
Dexedrine is primarily used to treat ADHD and narcolepsy, offering benefits such as improved attention and wakefulness.
While primarily for ADHD and narcolepsy, dextroamphetamine, the active ingredient in Dexedrine, has also been studied for other uses, though these are less common or off-label.
Dexedrine works as a central nervous system stimulant by affecting certain natural substances in the brain.
The mechanism of action of amphetamines like dextroamphetamine involves increasing the release and blocking the reuptake of neurotransmitters such as dopamine and norepinephrine in the brain.
This action helps to improve communication between brain cells, leading to increased attention and decreased impulsivity and hyperactivity.
Dexedrine comes in liquid, tablet, and extended-release capsule forms:
Dexedrine Tablet dosage varies based on individual needs and medical conditions. Always follow a doctor's guidance for safe use.
| Age Group / Condition | Initial Dose | Titration / Max Dose | Notes |
|---|---|---|---|
| Adults - ADHD (IR) | 5mg once or twice daily | Increase by 5mg/week; rarely exceed 40mg/day | Doses 4 -6hrs apart; avoid late dosing |
| Adults - ADHD (ER/Spansule) | 5mg once daily (morning) | Increase by 5mg/week; max ~40mg/day (may reach 60mg in select cases) | Oncedaily extended release |
| Adults - Narcolepsy | 10mg once daily (morning) | Increase by 10mg/week; usual range 5 -60mg/day in divided doses | Divide 1 -3 doses/day; avoid evening dose |
| Children 3 -5yrs - ADHD | 2.5mg once daily (IR) | Increase by 2.5mg/week; seldom exceed 40mg/day | Limited efficacy/safety data in this group |
| Children ≥6yrs - ADHD (IR) | 5mg once or twice daily | Increase by 5mg/week; max ~40mg/day | Divide doses 4 -6hrs apart |
| Children ≥6yrs - ADHD (ER/Spansule) | 5mg once daily (morning) | Increase by 5mg/week; max ~40mg/day (up to 60mg if >50kg) | Oncedaily extended release |
| Children 6 -11yrs - Narcolepsy | 5mg once daily | Increase by 5mg/week; up to ~60mg/day | Use IR or ER; avoid evening dosing |
| Adolescents ≥12yrs - Narcolepsy | 10mg once daily | Increase by 10mg/week; up to ~60mg/day | Divide into 1 -3 doses/day |
| Geriatric - Narcolepsy | 5mg once daily | Increase by 5mg/week; max ~60mg/day | Start low and go slow; monitor closely |
If you miss a dose of Dexedrine, take it as soon as you remember. Skip it if it's close to your next dose, and never double the dose to make up for a missed one.
An overdose of Dexedrine can be dangerous and harm bodily functions. Seek immediate medical attention if you suspect an overdose.
Key Dosage Tip: Follow your doctor's instructions carefully. Proper timing and dosage prevent complications.
Get a second opinion from trusted experts and makeconfident, informed decisions.
Get Second OpinionDexedrine, like any medication, may cause side effects, ranging from mild to severe. Most people tolerate it well, but awareness is key.
Specific individuals should exercise caution or avoid Dexedrine due to potential health risks or interactions.
Alcohol or Food Interactions:
Key Precaution: Dexedrine isn't safe for everyone. Discuss your medical history with your doctor.
Dexedrine can interact with other medications or supplements, potentially causing adverse effects. Always inform your doctor about all products you use.
Key Interaction Note: Share your medication list with your doctor. This prevents harmful drug interactions.
Proper storage ensures Dexedrine remains effective and safe. Keep it in a secure, controlled environment.
Improper storage may reduce the medication's effectiveness or make it unsafe to use.
| Dexedrine | Adderall |
|---|---|
| Contains only dextroamphetamine. | Contains a combination of amphetamine and dextroamphetamine. |
| Used to treat ADHD, improve focus, and manage behavioral issues. | Treats hyperactivity and controls impulses. |
| Modifies concentrations of natural substances in the brain. | Enhances the effects of neurotransmitters like dopamine and norepinephrine. |

Still have questions? Speak with our experts now!
040-68334455Yes, Dexedrine is a Schedule II controlled substance due to its high potential for abuse, which can lead to tolerance, psychological dependence, and severe social disability.
Dexedrine increases dopamine and norepinephrine activity in the brain, stimulating areas that control attention and movement to alleviate ADHD and narcolepsy symptoms.
Yes, Dexedrine is a central nervous system stimulant approved for treating ADHD and narcolepsy, a condition causing severe daytime drowsiness.
Dexedrine contains only the most potent form of amphetamine, while Adderall combines two active forms. Responses vary, but most people with ADHD react similarly to both.
Dexedrine boosts dopamine and norepinephrine, enhancing focus and potentially causing pleasurable feelings due to its effect on the brain's reward system.
As a stimulant, Dexedrine typically starts working within 30 minutes to an hour. Its short-acting tablets have a half-life of four to six hours.
Yes, Dexedrine can cause weight loss by reducing appetite and increasing calorie burning. It is sometimes used to treat binge eating or aid weight loss.
A 5mg Dexedrine pill contains dextroamphetamine, a stimulant used to treat ADHD (attention deficit hyperactivity disorder) and narcolepsy. It helps improve focus, attention, and alertness by increasing certain brain chemicals like dopamine.
In India, Dexedrine (dextroamphetamine) is not commonly available under the same brand name. It is a controlled substance and is not widely marketed due to strict regulations around stimulant medications. If prescribed, doctors may use alternatives like methylphenidate (available as Concerta, Addwize, or Intuniv) for ADHD.
Disclaimer: The information provided is accurate and up-to-date to the best of our knowledge. However, it should not be considered a substitute for medical advice or consultation. We do not guarantee its completeness or accuracy. The absence of specific warnings does not mean a medicine is safe for all users. We are not responsible for any outcomes based on this information and strongly recommend consulting a doctor for any medical concerns or questions.