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Desipramine

desipramine

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By Medicover Hospitals / 21 April 2021
Home | Medicine | Desipramine
  • Desipramine is in a class of drugs known as tricyclic antidepressants, it is a prescription medication. It comes in the form of a tablet that you take orally. Norpramin is a brand name for this medicine. It is a generic form of medication. It may be used in conjunction with other medications.
    1. Desipramine Uses
    2. Desipramine Side effects
    3. Precautions
    4. Interactions
    5. Dosage
    6. Storage
    7. Desipramine vs Amitriptyline
    8. Frequently Asked Questions
    9. Citations

    Desipramine Uses:

  • It is a medication used to treat depression. This medication may improve your mood, sleep, appetite, and energy level, as well as help you regain interest in your daily activities. This medication belongs to the class of drugs known as tricyclic antidepressants. It works by restoring the balance of a natural substance in the brain (norepinephrine).
  • How to use Desipramine HCL?

  • Examine the Medication Guide, which is available from your pharmacist.
  • Take this medication orally, with or without food, as directed by your doctor, 1 to 3 times per day. The dosage depends on your medical health condition as well as your response to treatment. Your doctor may begin with a low dose and gradually increase it. This medication may cause you to be sleepy or awake. As a result, depending on how this medication affects you, your doctor may advise you to take the entire dose once daily, either in the morning or before bed.
  • Pay close attention to your doctor's instructions. Do not take more or less medication than prescribed, or take it more frequently. Your condition will not improve faster, and your chances of experiencing side effects will increase. To get the most out of this medication, take it on a regular basis. Use it at the same time every day to help you remember.
  • This medication does not take effect immediately. When this medication is used to treat depression, it may take 2 to 3 weeks before you feel the full effects.
  • Side Effects

  • The more common side effects of bisoprolol oral tablet are,
    • Drowsiness
    • Dizziness
    • Dry mouth
    • Blurry vision
    • Trouble urinating
    • Constipation
    • Vomiting
    • Loss of appetite
    • Sexual problems
    • Dry or burning eyes
    • Fast heart rate
    • High Blood Pressure

    Precautions

  • Inform your doctor if you are allergic to it, or to other tricyclic antidepressants (such as imipramine or amitriptyline), or if you have any other kind of allergies. Some inactive ingredients present in this product may lead to complications or other problems.
  • Tell your doctor about the medical history, especially if you have: breathing problems, a personal or family history of glaucoma, diabetes, eating disorders, heart problems, liver problems, kidney problems, a personal or family history of other mood conditions, seizures, an overactive thyroid, trouble urinating, any condition that may increase your risk of seizures, or certain types of tumors.
  • It has been linked to a heart rhythm disorder (QT prolongation). QT prolongation can cause serious irregular heartbeat and other symptoms that require immediate medical attention.
  • If you have certain medical conditions or are taking other drugs that may cause QT prolongation, your risk of QT prolongation may be increased. Before taking this, inform your doctor or pharmacist about all the medications you are taking, as well as if you have any of the following conditions: specific heart problems, a family history of specific heart problems.
  • Low potassium and magnesium levels in the blood may also increase your risk of QT prolongation. If you use certain drugs or have conditions like severe sweating, diarrhea, or vomiting, your risk of developing this condition may increase. Consult your doctor about how to use it safely.
  • Get up slowly when rising from a seated or lying position to reduce dizziness and lightheadedness.
  • If you are a diabetic patient, this medication might make it more difficult to control your blood sugar. If you experience symptoms such as increased thirst or urination, contact your doctor right away. Your diabetes medication and exercise program may need to be adjusted by your doctor.
  • Older adults may be more sensitive to the drug's side effects, particularly dizziness, drowsiness, constipation, difficulty urinating, mental/emotional changes, and heart effects such as QT prolongation. Dizziness, drowsiness, and confusion can all increase the likelihood of a fall.
  • When administering this medication to children, use caution.
  • During pregnancy, this medication should not be used. Infants born to mothers who took similar medications during pregnancy may experience symptoms such as difficulty urinating, excessive sleepiness, shaking, and seizures.
  • This medication might pass in breast milk and may have unfavorable effects on a nursing infant. Before breastfeeding, talk to your doctor.
  • Interactions

  • Drug interactions can transform the way your medications function or put you at risk for serious side effects. Disopyramide, anticholinergics (including atropine, belladonna alkaloids, and scopolamine), certain blood pressure medications (such as clonidine, guanadrel, and guanethidine), digoxin, thyroid supplements, and valproic acid are examples of products that may interact with this medication.
  • Using MAO inhibitors in conjunction with this medication may result in a serious (possibly fatal) drug interaction. Avoid taking MAO inhibitors. Most MAO inhibitors should also be avoided for two weeks prior to and following treatment with this medication. Consult your doctor about when to begin or stop taking this medication.
  • Missed Dose

  • If you forget to take one of the dosages, take it as soon as you remember. Skip the missed dose and proceed with your daily schedule. To cope up with a missed dose, do not take a double dose.
  • Overdose

  • Overdose of a drug can be accidental. If you have taken more than the prescribed tablets there is a chance of getting a harmful effect on your body’s functions.
  • Storage

  • Exposure of medicine to heat, air, and light may cause some harmful effects. The medicine must be kept in a safe place and out of children’s reach.
  • Desipramine vs Amitriptyline

    Desipramine
    Amitriptyline
    It is a prescription medication. It comes in the form of a tablet that you take orally. It comes under the brand name Norpramin. Amitriptyline, also known as Elavil, is a tricyclic antidepressant that is primarily used to treat major depressive disorder
    It is a medication used to treat depression. This medication may improve your mood, sleep, appetite, and energy level, as well as help you regain interest in your daily activities. It is used for treating depression symptoms and kinds of pain syndromes ranging from neuropathic pain to fibromyalgia to migraine and tension headaches.
    It works by restoring the balance of a natural substance in the brain (norepinephrine). It works by increasing the levels of certain natural substances in the brain that are required for mental balance.

    Frequently Asked Questions:

    It is a medication used to treat depression. This medication may improve your mood, sleep, appetite, and energy level, as well as help you regain interest in your daily activities. This medication is in a class of drugs known as tricyclic antidepressants.
    It might take 2 to 3 weeks for you to get the benefits from this medication. Even if you feel fine, keep taking it. Do not discontinue this without first consulting your doctor.
    The half-life of this medicine, a tricyclic antidepressant, ranges from 12 to 54 hours. It is imipramine's pharmacologically active metabolite. Both substances bind to plasma proteins up to 95% of the time.
    This medication may cause significant increases in pulse rate, reclining systolic and diastolic blood pressures, and orthostatic hypotension. These effects were immediately apparent during the first week of treatment and remained relatively consistent for the next five weeks.
    Imipramine and desipramine have been linked to insomnia and increased sleep disruption. TCAs that cause sedation include doxepin, amitriptyline, and trimipramine.
    This medication helps in improving your sleep, mood, appetite, and energy level.
    It could be used in patients with constipation for abdominal pain while simultaneously treating constipation with other agents.
    This medication has the potential to cause constipation. Attempt to have a bowel movement every 2 to 3 days. If you haven't had a bowel movement in three days, contact your doctor or a healthcare professional.
    Yes, it may cause hair loss because the side effects can lead to loss of hair.
    This medicine is a tricyclic antidepressant that is used for treating neuropathic pain.

    Citations:

  • Desipramine, https://ascpt.onlinelibrary.wiley.com/doi/abs/10.1038/clpt.1990.33
  • Desipramine Side Effects, https://www.nejm.org/doi/full/10.1056/NEJM199205073261904