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By Medicover Hospitals / 06 March 2021
Home | Medicine | Combiflam
  • Combiflam Tablet combines two medicines that work as painkillers. They're working together to reduce pain, fever, and inflammation. It is used to treat many conditions such as headache, muscle pain, period pain, toothache, and joint pain.
  • Combiflam Tablet is best taken with food to minimize side effects. The doctor will decide on the dose and how often you need it. You should take it on a regular basis as advised by your doctor. It is intended for short-term use only. Consult your doctor if symptoms persist or worsen, or if the medicine is needed to use beyond 3 days.
  • Combiflam medicine is widely prescribed and considered safe, but may not be suitable for everyone. Before taking it, tell your doctor if you drink a lot of alcohol, use blood-thinning medicines, or have asthma or any problems with your liver or kidneys. The dose or suitability of this medicine may be affected. Pregnant or breast-feeding women should also consult their doctor before using it. Let your doctor know about all the other medicines you are taking because they may affect this medicine. It is best to avoid drinking alcohol while taking this medicine.
    1. Combiflam Uses
    2. Combiflam Side effects
    3. Precautions
    4. Dosage
    5. Storage
    6. Combiflam vs Flexon
    7. Frequently Asked Questions

    Combiflam Uses:

    • Combiflam Tablet contains two medicines: Paracetamol and ibuprofen, both widely used as painkillers. They work in a variety of ways to reduce pain, swelling, and inflammation. This medicine is very effective in treating mild to moderate migraine-related pain, headache, back pain, menstrual pain, dental pain, and rheumatic and muscular pain. The anti-inflammatory component makes this medicine more effective in the treatment of strains, sprains, and muscle pain.
    • Fever: Combiflam tablet provides temporary relief from pain and fever but does not treat the underlying cause. The doctor should therefore be consulted in order to diagnose the cause.
    • Pain (mild to moderate): Combiflam tablets are used to treat pain that may be associated with a toothache, body pain, etc. The pain may vary from mild to moderate.
    • Menstrual cramps: Combiflam medicine is found to be effective in women's menstrual cramps and associated abdominal conditions.
    • Osteoarthritis: Combiflam Tablet is used to treat symptoms of osteoarthritis, including tender and swollen joints.
    • Rheumatoid Arthritis: Combiflam is used to treat symptoms of rheumatoid arthritis, including pain, stiffness, and swelling of the joints.
    • Gout: Combiflam Tablet helps to relieve gout-related swelling and pain.
  • The Combiflam Tablet only helps to relieve symptoms and not the underlying cause. The doctor should therefore be consulted and the proper course of treatment should be taken in accordance with the clinical condition.
  • How to use:

    • Take this medicine at the dose and duration recommended by your doctor. Swallow it down as a whole. Do not chew, crush or break it down. Combiflam Tablet should be taken with food.
    • Combiflam should be taken with a meal.
    • The Combiflam dose should be kept strictly to the doctor's prescription.
    • Alcohol should be avoided while using Combiflam.
    • Before using the medicine, check for ingredients to avoid any kind of complications.
    • Ongoing drugs should be discussed with a physician beforehand in order to avoid the risk of interaction.

    How does it work

  • Combiflam Tablet works by blocking the Cyclooxygenase Synthesis (or COX2). It is an enzyme responsible for the stimulation of prostaglandins in the body. The release of prostaglandins results in inflammation, swelling, and joint pain.
  • By blocking the production of cyclooxygenase (COX2), prostaglandin synthesis is also inhibited. This medicine is used to relieve conditions such as migraine, osteoarthritis, joint swelling, rheumatoid arthritis, inflammation, menstrual pain, postoperative pain, and fever.
  • The drug blocks the production of all enzymes or components that stimulate the inflammation process, such as free radicals, proteolytic enzymes, cyclooxygenase, histamine, and prostaglandin. It also helps to relieve acute pain due to menstrual cramping, stiff neck, and osteoarthritis. Combiflam Tablet works at brain centers responsible for maintaining body temperature and reducing the temperature of the body.
  • The effect of Combiflam can be seen in half an hour to one hour. It lasts for an average duration of 4-6 hours.
  • Side Effects:

    • Diarrhea
    • Decreased urine output
    • Abdominal pain
    • Drowsiness
    • Constipation
    • Blood in vomit
    • Stomach pain
    • Headache
    • Epigastric pain
    • Buzzing in the ears
    • Heartburn
    • Fluctuations in blood count
    • Nausea
    • Fatigue
    • Vomiting
    • Yellow-colored skin or eyes
    • Swelling
    • Cloudy or bloody urine
    • Rash
    • Edema
    • Itching
    • Breathlessness
    • Liver damage
    • Steven-Johnson syndrome
    • Kidney damage
    • Anaphylactic reaction
    • Anemia
    • Mouth ulcer
    • Appetite loss


  • One should not take this medicine when,
    • If an individual is allergic to a Combiflam tablet or any of its ingredients.
    • If an individual is allergic to non-steroidal anti-inflammatory drugs (NSAIDs) such as Diclofenac, Aspirin, etc.
    • If there was an asthma attack, swelling of the face, itchy red bumps on the skin, bleeding in the stomach, or irritation of the nose.
    • If there is a history of stomach bleeding or stomach/intestinal ulcers.
    • If a person has a liver or kidney disease.
    • If an individual has had heart failure, heart disease, or stroke.
    • If an individual has any blood disorder or porphyria.
    • If the individual has any breathing problems.

    Missed Dose

  • If you miss a dose some sudden chemical change may affect your body. In some cases, your doctor would advise you to take the prescribed medicine as soon as possible if you have missed the dose.
  • Overdose

  • Overdose of a drug can be accidental. If you have taken more than the prescribed Combiflam tablets there is a chance of getting a harmful effect on your body’s functions. Overdose of a medicine can lead to some medical emergency.
  • Storage

  • Direct contact with heat, air, and light may damage your medicines. Exposure to medicine may cause some harmful effects. The medicine must be kept in a safe place and out of children’s reach. Mainly the drug should be kept at room temperature between 68ºF and 77ºF (20ºC and 25ºC).
  • Combiflam vs Flexon

  • Sanofi India Ltd
  • Aristo Pharmaceuticals Pvt Ltd
  • Ibuprofen (400mg) + Paracetamol (325mg)
  • Ibuprofen (400mg) + Paracetamol (325mg)
  • It is used for the treatment of many conditions such as headache, muscle pain, pain during periods, toothache, and joint pain. It is used for the treatment of many conditions such as headache, muscle pain, pain during periods, toothache, and joint pain.

    Frequently Asked Questions:

    Adults: 1 tablet 3 times a day, or as directed by your doctor.
  • Adults with a bodyweight of 40 kg or more (who are 12 years of age and above) - initial dose, 1 tablet of Combiflam. Additional doses of Combiflam tablets may be taken if necessary.
  • Combiflam can make lung problems worse for people with respiratory disorders such as asthma. As a non-steroidal anti-inflammatory drug (NSAID), it can cause problems if it is overused. It may lead to prolonged problems such as high blood pressure, prostate problems, thyroid disease, or heart disease.
    The total dose of 3 Combiflam tablets should not be exceeded in any 24-hour period. Only for short-term use. If Combiflam tablets are required in adults for more than 3 days in the case of fever or for more than 4 days in the treatment of pain, or if symptoms worsen, the patient is advised to consult a physician.
    Combiflam Tablet contains two medicines for analgesics. They're working together to reduce pain, fever, and inflammation. It is used to treat many conditions such as headache, muscle pain, period pain, toothache, and joint pain.
    Common pain killer medicines also called non-steroidal anti-inflammatory drugs such as bruf, combiflam, and voveran are known to cause kidney damage when taken regularly. Such medications are not likely to pose a significant risk if the kidneys are relatively healthy and used only in emergency situations.
    Combiflam Plus may be used for symptomatic relief from mild to moderate pain in conditions such as headache, migraine, muscle pain and back pain, tooth pain and other musculoskeletal pain (body pain).
    Side effects of Combiflam Tablets are-
    • Stomach pain
    • Diarrhea
    • Vomiting
    • Dizziness
    • Bloating
    • Constipation
    • Headache
    • Excessive sweating
    Overdose of any medicine may cause life-threatening conditions, such as liver damage, which is the most serious side effect, and Combiflam Plus is no different. Early symptoms may include nausea, vomiting, severe sweating, and general tiredness.
    Combiflam Gel can be used for pain in the joints, neck and shoulder, muscles and back. The gel has dual Icy and Hot action, which reduces swelling and repairs muscles.


  • Combiflam,
  • Combiflam Mixtures,