Combiflam is a widely prescribed medication that combines two powerful painkillers, paracetamol and ibuprofen, to provide effective relief from pain, fever, and inflammation. It is commonly used to manage conditions such as headaches, muscle pain, period pain, toothaches, and joint pain.
Known for its quick action and effectiveness, Combiflam is a go-to choice for short-term symptom relief, but it'should always be used under medical guidance to ensure safety.
What is Combiflam?
Combiflam is a combination medication containing Paracetamol (325 mg) and Ibuprofen (400 mg) per tablet, known as the Combiflam composition. Paracetamol acts as an analgesic (pain reliever) and antipyretic (fever reducer), while Ibuprofen, a non-steroidal anti-inflammatory drug (NSAID), reduces pain and inflammation.
This dual-action formula makes Combiflam effective for a wide range of symptoms. It is available in tablet form for adults and as Combiflam Syrup for children aged 6 months and above, ensuring accessibility for different age groups.
What Are the Uses of Combiflam Tablet?
Combiflam offers relief for various conditions, making it a versatile medication.
Its Primary Benefits and Uses Include
Fever Reduction: Combiflam provides temporary relief from fever but does not address the underlying cause, so consulting a doctor for a proper diagnosis is essential.
Pain Relief: It effectively manages mild to moderate pain, including:
Inflammation Management: Combiflam helps reduce inflammation in conditions such as:
Osteoarthritis (tender and swollen joints)
Rheumatoid arthritis (pain, stiffness, and swelling in joints)
Gout (swelling and pain due to uric acid buildup)
Secondary Uses
While primarily used for the conditions listed above, Combiflam may also be prescribed for other pain-related issues as determined by a healthcare provider. For children, Combiflam Syrup is used to relieve fever, toothache, headache, and muscle pain, making it a suitable option for pediatric care under medical supervision.
How Does Combiflam Work?
Combiflam's effectiveness comes from the combined action of its two active ingredients:
Paracetamol: Works in the brain's hypothalamus to reduce fever and inhibits prostaglandin synthesis in the central nervous system, which helps alleviate pain.
Ibuprofen: Blocks the production of prostaglandins throughout the body, chemicals responsible for pain, fever, and inflammation, thus reducing swelling and discomfort.
This dual mechanism allows Combiflam to provide comprehensive relief, typically within 30 minutes of administration, with effects lasting around 6 hours.
Dosage Strengths of Combiflam
Combiflam is available in multiple strength combinations of Paracetamol and Ibuprofen, designed to offer flexibility in treating varying degrees of pain, inflammation, and fever.
Combiflam Tablets are commonly available in the following strengths:
500 mg + 200 mg (Paracetamol + Ibuprofen)
325 mg + 400 mg
325 mg + 9.75 mg
Combiflam Suspension is available for pediatric or liquid dosing needs:
100 ml + 162.5 ml formulation
These dosage strengths are prescribed based on the severity of symptoms, patient age, and medical history. Always follow your doctor's instructions to ensure safe usage.
Dosage Forms of Combiflam
Combiflam comes in two primary dosage forms to suit patient preferences and clinical needs:
Oral Tablets: These are the most commonly prescribed form, used for general pain relief and fever in adults. Available in fixed-dose combinations of Paracetamol and Ibuprofen.
Oral Suspension: Designed especially for children or patients who have difficulty swallowing tablets. The liquid form ensures accurate dosing based on weight or age and provides ease of administration.
Each form of Combiflam is formulated to deliver effective relief while maintaining safety across different age groups and health conditions.
Combiflam Dosage
Combiflam should always be taken as prescribed by a healthcare provider to ensure safety and effectiveness. General guidelines include:
Adults: Typically, one tablet every 4 to 6 hours as needed, not exceeding 4 tablets in 24 hours.
Children (6 months and above): Combiflam Syrup dosage depends on the child's age and weight, and a pediatrician's guidance is crucial.
Patient Group
Condition/Parameter
Dosage Adjustment Guidance
Kidney Patients
Creatinine Clearance (CrCl) < 10 mL/min
Paracetamol: Administer at minimum 8-hour intervals; avoid chronic use.
Glomerular Filtration Rate (GFR) 30-60 mL/min
Avoid Ibuprofen use during intercurrent illness due to increased AKI risk.
GFR < 30 mL/min
Avoid Ibuprofen use entirely.
Advanced renal disease
Avoid Ibuprofen unless benefits outweigh risks; monitor renal function closely.
Hepatic Impairment Patients
Hepatic dysfunction
Use Paracetamol with caution.
Chronic hepatic disease
Use the smallest effective Paracetamol dose for the shortest duration.
Ibuprofen dosage guidelines
Not well established; use with caution.
Pediatric Patients
Paracetamol metabolism
Primarily excreted as sulfate conjugate due to immature glucuronide pathways; adult-like metabolism achieved by age 12.
Ibuprofen pharmacokinetics
Half-life 0.9-2.3 hours; higher volume of distribution in children <2.5 years; adolescent kinetics similar to adults.
Key Instructions:
Take Combiflam with food to reduce the risk of stomach upset.
Follow the prescribed dose and duration strictly.
Avoid alcohol, as it increases the risk of stomach bleeding and liver damage.
What Should I Do If I Miss a Dose of Combiflam?
If you miss a dose, take it as soon as you remember. However, if itand's nearly time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to compensate.
What Happens If I Overdose?
An overdose of Combiflam can be dangerous, potentially causing:
Symptoms: Nausea, vomiting, abdominal pain, drowsiness, and in severe cases, liver failure (from Paracetamol) or gastrointestinal bleeding and kidney damage (from Ibuprofen).
Action: Seek immediate medical attention if an overdose is suspected.
What to Avoid:
Alcohol consumption heightens the risk of serious side effects.
Other medications containing Paracetamol or NSAIDs should be used without consulting a doctor.
Taking Combiflam for stomach pain, as it may indicate an underlying issue like a stomach ulcer.
In case of overdose or severe symptoms, visit our Hospital for proper care.
Get a second opinion from trusted experts and makeconfident, informed decisions.
Advice: If you experience severe or persistent side effects, stop taking Combiflam and consult your doctor immediately. Persistent nausea, vomiting, or signs of dehydration (e.g., dark urine or reduced urination) require urgent medical attention.
Methotrexate: Increased risk of methotrexate toxicity.
Depression Medications: May interact, so inform your doctor.
Supplements and Herbal Products
Some herbal products or supplements may interact with Combiflam, so always inform your doctor about all medications and supplements you are taking to avoid complications.
Store at room temperature between 68°F and 77°F (20°C and 25°C).
Keep away from heat, moisture, and direct sunlight.
Store out of reach of children and pets.
Avoid storing in bathrooms or near kitchen sinks.
Discard unused medication after the expiration date or as advised by a pharmacist.
What Happens If Combiflam Is Not Stored Properly?
Improper storage can degrade the active ingredients, reducing effectiveness or making the medicine unsafe. Exposure to heat, moisture, or light may cause chemical changes.
Combiflam vs Flexon
Combiflam
Flexon
Manufacturer: Sanofi India Ltd Salt Composition: Ibuprofen (400mg) + Paracetamol (325mg) Uses:
Combiflam is used to relieve pain, reduce inflammation, and lower fever. It combines ibuprofen and paracetamol, making it effective for headaches, toothaches, menstrual pain, and joint or muscle pain.
Paracetamol is a single-ingredient medicine for pain and fever, while Combiflam combines paracetamol with ibuprofen to provide both pain relief and anti-inflammatory effects.
Yes, long-term or excessive use of Combiflam can cause gastrointestinal problems, kidney issues, or allergic reactions. It should always be taken as directed by a healthcare provider.
Combiflam may affect kidney function, especially with prolonged use or in people with existing kidney conditions. Use with caution and under medical advice.
Combiflam is not commonly associated with drowsiness, but individual reactions can vary. If you feel sleepy after taking it, consult your doctor.
Yes, Combiflam can help ease throat pain due to its anti-inflammatory and pain-relieving properties, but it should not replace targeted treatment for infections.
Combiflam may be given to children only in child-appropriate formulations and dosages, and strictly under a doctor’s supervision.
Crocin (paracetamol) is ideal for reducing fever and mild pain, while Combiflam is better when inflammation is also present. The right choice depends on the condition and doctor’s recommendation.
Combiflam may provide temporary relief for mild nerve pain, but it is not specifically formulated for neuropathic pain. Consult a doctor for suitable alternatives.
The usual duration is 5 to 7 days, but it may extend to 10 to 14 days for more severe infections or as directed by your doctor.
Disclaimer: The information provided is accurate and up-to-date to the best of our knowledge. However, it should not be considered a substitute for medical advice or consultation. We do not guarantee its completeness or accuracy. The absence of specific warnings does not mean a medicine is safe for all users. We are not responsible for any outcomes based on this information and strongly recommend consulting a doctor for any medical concerns or questions.
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