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Cefoperazone

Cefoperazone

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By Medicover Hospitals / 29 Nov 2020
Home | Medicine | Cefoperazone

What is Cefoperazone?

Cefoperazone is a semisynthetic broad-spectrum cephalosporin. It’s effective against pseudomonas infections. These are third-generation antibiotic agent which works in the treatment of various bacterial infections that are caused by the susceptible organisms in the body. The bacterial infections include respiratory tract infections, skin infections, endometritis and bacterial septicemia.

  1. Cefoperazone Uses
  2. Cefoperazone Side Effects
  3. Dosage
  4. Precautions
  5. Cefoperazone warnings
  6. Frequently Asked Questions
  7. Citations

Cefoperazone Uses:

Cefoperazone is used for various treatments:

  • Bone disease
  • Escherichia coli infections
  • Genital disease
  • Haemophilus infections
  • Pneumonia
  • Bacterial infections
  • Proteus infections
  • Pseudomonas infection
  • Skin diseases
  • Soft tissues
  • Urinary tract infections

For further use of Cefoperazone tablets consult with your doctor.

Cefoperazone Side Effects:

Common Cefoperazone Side effects

  • Anemia
  • GI bleeding
  • Hemolytic anemia
  • Leukopenia
  • Bone marrow
  • Depression
  • Bleeding
  • Dizziness
  • Anorexia
  • Dyspnea
  • Abdominal pain
  • Skin Rashes

Serious Cefoperazone Side Effects:

  • Hypersensitivity
  • Hematology
  • Hepatic
  • Gastrointestinal
  • Blood and lymphatic system disorders
  • Immune system disorders
  • Hepatobiliary disorders
  • Skin tissue disorders
  • Vascular Disorders

Precautions:

If Cefoperazone is suggested to a patient without any proven bacterial infection then there is very less chance of getting any benefit from Cefoperazone tablets. In fact, it will show some adverse effects on the body. Patients who are taking Cefoperazone should avoid alcohols for 72hours.

Avoid using Cefoperazone if you have faced these problems:

  • If you ever got allergic
  • Inform your doctor if you have these problems:
    • Liver Disease
    • Kidney Disease
    • Myasthenia Gravis
    • Heartbeat disorder
    • Low levels of potassium in the blood

Cefoperazone Dosage:

Adult dose for Endometritis
1 to 2 g IV in every 12 hours to continue until 48 hours till the clinical improvement has been seen.
Adult dose for Febrile Neutropenia
1 to 2 g IV in every 12 hours. This therapy should be continued for 14 days.
Adult dose for joint infection
1 to 2 g IV in every 12 hours for 3 to 4 weeks. The longer therapy can be for 6 weeks.
Adult dose for Pelvic inflammatory disease
1 to 2 g IV in every 12 hours until 48 hours till any improvement observed in the patient’s body.
Adult dose for Pneumonia
1 to 2 g IV in every 12 hours for 7 to 21 days which depend on the causative organisms.

Missed Dose:

Missing one or two-dose of Cefoperazone won’t show any effect on your body. The skipped dose causes no problem. But with some medication, it won’t work if you don’t take the dosage on time. If you miss a dose some sudden chemical change may affect your body. In some cases, your doctor would advise you to take the prescribed medicine as soon as possible if you have missed the dose.

Overdose:

Overdose of a drug can be accidental. If you have taken more than the prescribed Cefoperazone tablets there is a chance of getting a harmful effect on your body’s functions. Overdose of a medicine can lead to some medical emergency.

Cefoperazone Warnings:

  • Hypersensitivity reactions
  • Clostridium Difficile-Associated Diarrhea
  • Hemorrhage

People with serious health conditions:

Pregnant women

Cefoperazone is not evaluated for pregnant women. If a woman is using the drug during her pregnancy there is no such high risk of pregnancy loss, birth defects or any other problems. But to be on safe side consult your doctor before taking the medicine.

Breastfeeding

Cefoperazone pass into the breast milk. It can cause some side effects to child’s who are breastfed. These can include diarrhea, vomiting and rash. Before taking Cefoperazone while breastfeeding consult your doctor.

Storage:

Direct contact with heat, air and light may damage your medicines. The exposure of medicine may cause some harmful effects. The medicine must be kept in a safe place and out of children reach. Mainly the drug should be kept at room temperature between 68ºF and 77ºF (20ºC and 25ºC).

Before taking Cefoperazone consult your Doctor. In case if you face any problems or get any side effects after taking Cefoperazone rush immediately to your nearby hospital or consult your doctor for better treatment. Carry your medications always in your bag while travelling to avoid any immediate emergencies. Follow your prescription and follow your Doctor advice whenever you take Cefoperazone

Cefoperazone Ceftriaxone
It is a semisynthetic broad-spectrum cephalosporin. It’s a cephalosporin antibiotic.
Side effects are vomiting, nausea, haematology, hepatic and gastrointestinal Side effects are sore throats, fever, cough, breathlessness, unusual bleeding and weakness
1 to 2 g IV in every 12 hours to continue until 48 hours till the clinical improvement has been seen. Adult dose for bacteremia IS 1 to 2 g IV or IM once in a day. The duration of therapy should be 4-14 days

Frequently Asked Questions:

Cefoperazone is a semisynthetic broad-spectrum cephalosporin. It’s effective against pseudomonas infections. These are third-generation antibiotic agent which works in the treatment of various bacterial infections that are caused by the susceptible organisms in the body.
These are not very useful for the treatment of meningitis as this doesn’t penetrate the blood-brain barrier.
Cefoperazone is not evaluated for pregnant women. If a woman is using the drug during her pregnancy there is no such high risk of pregnancy loss, birth defects or any other problems. But to be on safe side consult your doctor before taking the medicine.
These are third-generation antibiotic agent which works in the treatment of various bacterial infections that are caused by the susceptible organisms in the body.

Citations:

  • Pharmacokinetics of Cefoperazone: A Review, https://link.springer.com/article/10.2165/00003495-198100221-00010
  • Multiple-dose pharmacokinetics and toleration of intravenously administered cefoperazone and sulbactam when given as single agents or in combination, https://aac.asm.org/content/32/1/42.short