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Cabergoline

cabergoline
By Medicover Hospitals / 2 Feb 2021
Home | Medicine | Cabergoline

What is Cabergoline ?

  • Cabergoline is used to treat various forms of medical conditions caused by the development of too much of the hormone prolactin. It can be used to treat some menstrual issues, male and female fertility problems, and pituitary prolactinoma (tumors of the pituitary gland).
  • It functions by preventing the pituitary gland from producing and releasing the prolactin hormone from the brain. When prolactin levels are usual for 6 months, the use of cabergoline is normally stopped. When signs of too much prolactin arise again, it may be given again. This medication is available in tablet form for dosage.
    1. Cabergoline Uses
    2. Cabergoline Side effects
    3. Precautions
    4. Overdose
    5. Cabergoline Storage
    6. Cabergoline vs Bromocriptine
    7. Frequently Asked Questions
    8. Citations

    Cabergoline Uses:

  • This drug is used to treat the body with elevated levels of the hormone prolactin. Symptoms such as unwanted breast milk and missed periods can be caused by elevated levels of prolactin in women and can cause difficulties becoming pregnant. Symptoms such as enlarged breasts and diminished sexual ability/desire can be triggered by elevated levels of prolactin in men. Cabergoline is an ergot drug that functions by blocking the release of prolactin from the pituitary gland.
  • Cabergoline is also used to treat Parkinson's disease in some cases (a disorder of the nervous system that causes difficulties with movement, muscle control, and balance). Speak to your doctor about the complications of your condition using this drug.
  • How to use

    • Take this drug orally, with or without food, usually twice a week, or as prescribed by your doctor.
    • The dose is dependent on your medical condition and your treatment reaction (prolactin levels). In order to help minimize side effects, your doctor will start you at a low dose and slowly raise your dose over several months. Strictly follow the directions given by your doctor.
    • To get the most benefits from it, take this drug daily. Mark the days on the calendar that you need to take your medicine, to help you recall.

    Cabergoline Side Effects:

    • Nausea
    • Vomiting
    • Heartburn
    • Constipation
    • Tiredness
    • Dizziness
    • Breast pain
    • Painful menstrual periods
    • Burning sensation
    • Numbness feeling
    • Tingling sensation
    • Shortness of breath
    • Difficulty breathing when lying down
    • Cough
    • Chest pain
    • Swelling of the hands
    • Swelling of feet or ankles, or lower legs
    • Decrease in urination
    • Pain in the back, side, or groin
    • Lumps or pain in the stomach area
    • Abnormal vision

    Precautions:

    • If you are allergic to cabergoline, tell your doctor and pharmacist if you are allergic to ergot medications such as bromocriptine (Parlodel), dihydroergotamine (D.H.E. 45, Migranal), ergoloid mesylates (Hydergine), ergotamine (Cafergot, Ergomar), methylergonovine (Methergine), methysergide (Sansert), and pergolide (Permax), any other medications, or any of the ingredients in the tablets containing cabergoline. For a list of the ingredients, ask your pharmacist.
    • Keep in mind any of the following drugs: antihistamines; ergot medicines such as dihydroergotamine (D.H.E. 45, Migranal), ergotamine (Cafergot, Ergomar) and methylergonovine (Methergine); haloperidol (Haldol); levodopa (Parcopa, Sinemet, and Stalevo); high blood pressure, psychiatric disease, or nausea medicines; metoclopramide (Reglan); or thiothixene (Navane). Your doctor may need to adjust your prescription dosage or monitor your side effects carefully.
    • Tell your doctor whether you are using or have ever used street medications and whether you have or have ever had high blood pressure or any disease in your lungs, heart, or abdomen that causes thickening or scarring. And, whether you have or have ever had heart valve disease, notify your doctor. In order to see if your heart valves are safe, your doctor will assess you and order tests. If you have symptoms of heart valve disease or any of these conditions, your doctor may advise you not to take Cabergoline.
    • If you have liver-related health issues or have ever had a liver condition, tell your doctor.
    • If you are in your pregnancy period or planning to become pregnant, tell your doctor. Give your doctor a call if you get pregnant while taking Cabergoline.
    • If you are breast-feeding, tell your doctor or ask a doctor before doing. Cabergoline can delay or stop breast-milk development.
    • You should know that when you get up too rapidly from a lying position, cabergoline can cause dizziness, lightheadedness, and fainting. When you first start using cabergoline, this is more popular. Get out of bed slowly to avoid this problem, resting your feet on the floor for a few minutes before standing up.

    Interactions:

  • Antipsychotic drugs (such as chlorpromazine, haloperidol, thiothixene), lorcaserin, metoclopramide, prochlorperazine are some of the products that may interfere with this drug.Other drugs can have an effect on the body's removal of cabergoline, which can influence how cabergoline functions. Some azole antifungal agents (such as itraconazole, ketoconazole, posaconazole), cobicistat, and HIV protease inhibitors (such as ritonavir, saquinavir), among others, are instances.
  • Overdose:

  • Call a poison control center immediately if someone has overdosed and has severe signs such as passing out or difficulty breathing. Extreme dizziness, fainting, mental/mood changes can be signs of overdose (such as hallucinations).
  • Note:

  • Don't share with anyone this drug. In order to monitor your progress or check for side effects, laboratory and/or medical tests (such as prolactin levels, EKG) should be conducted before beginning and while you are taking this drug. For more info, contact your doctor.
  • Missed Dose:

  • If a missed dose is missed, take it as soon as you recall it. If the time for the next dose is close, skip the skipped dose. Take your next dose at a normal time. Do not double doses.
  • Storage:

  • Store it away from sunlight, heat, and moisture at room temperature. Do not store your things in the bathroom. Unless told to do so, do not flush drugs down the toilet or dump them into a drain. When it gets expired or no longer in use or needed, properly discard this product carefully. Consult your pharmacist or local business for waste disposal.
  • Cabergoline vs Bromocriptine:

    Cabergoline
    Bromocriptine
    Formula: C26H37N5O2 Formula: C32H40BrN5O5
    Molecular Weight: 451.6 g/mol Molar mass: 654.595 g/mol
    Elimination half-life: 63–69 hours (estimated) Elimination half-life: 12-14 hours
    Cabergoline is an ergot derivative Bromocriptine is an ergoline derivative
    Cabergoline is used to treat various forms of medical conditions caused by the development of too much of the hormone prolactin. Used in the treatment of pituitary tumors, neuroleptic malignant syndrome, Parkinson's disease, hyperprolactinemia, and, as an adjunct, type 2 diabetes.

    Frequently Asked Questions:

    For the treatment of hyperprolactinemia, cabergoline is used (high levels of prolactin, a natural substance that helps to breastfeed women produce milk but can cause symptoms such as infertility, sexual issues, and bone loss density in women who are not breast-feeding or can happen bone loss in men).
    The advantage of taking cabergoline is that the amount of prolactin in your blood can be decreased and the effects you have encountered can be reduced. It works by raising a chemical called dopamine in the brain, which decreases the amount of prolactin released.
    The impact is prompt and persistent (within 3 hours of administration) and (up to 7-28 days in healthy volunteers and hyperprolactinemic patients, and up to 14-21 days in puerperal women). The dose-dependent prolactin-lowering effect is related to both the degree of effect and the duration of action.
    Absorption: Mean plasma peak levels of 30 to 70 picograms (pg)/mL of Cabergoline were observed within 2 to 3 hours following single oral doses of 0.5 mg to 1.5 mg administered to 12 healthy adult volunteers.
    If you don't take it as recommended, it comes with significant risks. If you unexpectedly stop taking the medication or don't take it at all, the blood levels of prolactin will remain high. High prolactin levels in women can alter ovulation, menstrual cycles, and the development of breast milk.
    Cabergoline, an agonist of the dopamine receptor, has an antidepressant-like property and increases signalling of the brain-derived neurotrophic factor. Psychopharmaceuticals (Berl).
    Cabergoline is used to treat an excess of hormones when too much prolactin is found in the blood (also called hyperprolactinemia). For purposes not specified in this drug guide, Cabergoline can also be included.
    Some research indicates that cabergoline administration can normalize androgen levels and boost menstrual irregularity in PCOS women. They conclude that cabergoline may play a useful role in treating menstrual abnormalities in PCOS patients by reducing prolactin secretion (30-31).

    Citations:

  • Cabergoline, https://link.springer.com/article/10.2165/00003495-199549020-00009
  • Cabergoline in the Treatment,https://academic.oup.com/jcem/article/84/7/2518/2864450?login=true