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Ambroxol

Ambroxol

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By Medicover Hospitals / 29 Dec 2020
Home | Medicine | Ambroxol

What is Ambroxol?

  • Ambroxol is a clinically validated mucolytic agent that is systemically active. The initiation of the action occurs after about 30 minutes when administered orally. The degradation of the fibers of acid mucopolysaccharide makes the sputum thinner and less viscous and therefore easier to extract by coughing. While sputum volume gradually decreases, for as long as care is continued, its viscosity remains low.
  • This syrup is used for acute and chronic respiratory diseases.
  • Ambroxol Hydrochloride

  • Dosage Form: pills, tea, syrup
  • Ingredients: Each tablet contains 30 mg of ambroxol hydrochloride; every 5 ml of syrup contains 15 mg of ambroxol hydrochloride.
  • This is a mucolytic agent that decreases the sputum's thickness. It is used to treat pathological mucus secretion disorders, allowing the patient to breathe deeply and freely. In patients with a confirmed history of gastric ulcers, it should be used with caution.
    1. Ambroxol uses
    2. Ambroxol side effects
    3. Ambroxol Dosage
    4. Ambroxol Precautions
    5. Ambroxol Storage
    6. Ambroxol vs Acetylcysteine
    7. Frequently Asked Questions
    8. Citations

    Ambroxol Uses:

  • Emphysema with Pneumoconiosis Bronchitis
  • By making the sputum thin and less viscous and quick to cough out, this medication is used to relieve the state of shortness of breath, constant cough, and inflammation of the lung airways.
  • Tracheobronchitis, Tracheobronchitis
  • This drug is used for the symptomatic treatment of tracheobronchitis, an infection that induces tracheal (windpipe) and pulmonary airway inflammation. Ambroxol in this case relieves the patient from an excessive cough and thick sputum.
  • Acute Bronchitis Exacerbations
  • In cases of acute exacerbations of bronchitis, this drug should be given with the required antibiotic as it aids in the secretion of mucus, helping to improve cough, trouble with expectoration, and other symptoms.
  • Ambroxol Side Effects:

  • Major & minor side effects of ambroxol are
    • Nausea
    • Vomiting
    • Diarrhea
    • Gastrointestinal side effects
    • Skin rash
    • itching
    • Infections
    • Allergies
    • Upset stomach
    • Dizziness
    • Weakness
    • Dry mouth
    • Indigestion
    • Numbness in throat
    • Numbness in mouth
    • Taste disturbances

    Ambroxol Dosage:

  • Adults: normal dosage from 30 mg (one tablet of Ambroxol) to 120 mg (4 tablets of Ambroxol) taken in 2 to 3 divided doses.
  • Children up to 2 years: half a teaspoonful Ambroxol syrup twice regular
  • Kids 2 to 5 years of age: half a teaspoon of Ambroxol syrup three times a day.
  • Children 5 years and older: one teaspoon of Ambroxol syrup 2-3 times a day.
  • Precautions:

  • If you have any of the following conditions or symptoms, medical advice prior to use should be sought:
  • Symptoms suggestive of pneumonia or other lung infections (e.g. trouble breathing while sleeping, thick yellow or green mucus, blood-stained mucus, high-grade fever above 38 °C, chest pain), low immune system symptoms due to other health conditions (e.g. HIV) or drugs (e.g. chemotherapy, medication of the immune system) or current lung conditions such as COLD (chronic obstruction)
  • If you have serious gastric ulceration, liver or kidney issues, notify your healthcare professionals.
  • If you have a confirmed history of an allergy to ambroxol or bromhexine, or any of the other ingredients mentioned in the medicine, this drug should be avoided. Some ambroxol tablets can contain lactose as an inactive ingredient, so people who have inherited galactose intolerance, lactase deficiency (lactose digestive enzyme) or galactose absorption problems are not advised to take them.
  • It is not recommended to use Ambroxol during the first trimester of pregnancy. It is not recommended to take ambroxol when breastfeeding, as ambroxol is excreted in breast milk.
  • Before taking this drug, please seek the advice of your doctor or pharmacist if you are pregnant or breastfeeding.
  • How it works with ambroxol hydrochloride

  • Gaucher's disease is caused by GBA gene mutations that encode the enzyme glucocerebrosidase. In a specific compartment in the cell called the lysosome, this enzyme usually breaks down a complex lipid molecule called glucocerebroside. The mutation causes the enzyme that is newly synthesized to fold incorrectly. The enzyme is thus aimed at degradation by the cells' quality control mechanism, which prevents it from reaching its goal, the lysosomes.The glucocerebrosidase substrate, also accumulates in the lysosomes, causing symptoms such as swollen liver and spleen, bone pain and fragility, reduced red blood cell counts (anemia) and platelet counts (thrombocytopenia), and neuropathy.
  • Ambroxol hydrochloride is a small molecule which binds to and facilitates the proper folding of the enzyme glucocerebrosidase. It would promote the translocation to the lysosomes of glucocerebrosidase, where it will help in metabolizing glucocerebroside and relieve the disease's symptoms.
  • Warnings:

    • If you have cough from long time, speak to the doctor
    • Don't take if you have asthma or asthma attacks
    • If you have liver issues speak to your doctor about it
    • If you have kidney issues consult
    • If you are having ulcers avoid taking this.
    • Avoid if you are pregnant or planning for a baby
    • Before breastfeeding consult your doctor

    Missed Dose

  • If you miss a dose, use this drug as soon as you find it. Skip the missed dose and restart your dosing schedule if it is close to the time of your next dose. Do not use an additional dose in order to make up for the missing dose. Try setting an alarm or asking a family member to alert you if you are frequently skipping doses. If you have missed too many doses lately, please contact your physician to suggest adjustments in your dosing schedule or a new schedule to make up for missed doses.
  • Overdose

  • Do not take more than the dosage given. Your symptoms will not be changed by taking more medication; they can instead cause poisoning or severe side effects. If you believe that you or someone else might have overdosed on Ambroxol Hydrochloride Syrup, please go to the nearest hospital or nursing home emergency room. Bring with you a medication box, bottle, or mark to support doctors with the details needed.
  • Even if you know they have the same disorder or it seems like they may have similar conditions, do not give your drugs to other people. This can contribute to overdose.
  • For more details, please contact your doctor or pharmacist, or your product box.
  • Ambroxol Storage:

  • Medicines should be kept at room temperature, away from heat and direct light. Unless required by the package insert, do not freeze medicines. Keep medication away from pets and children.
  • Unless told to do so, do not flush drugs down the toilet or spill them into drainage. The atmosphere may be polluted by drugs discarded in this way. For more information on how to safely discard Ambroxol Hydrochloride Syrup, please contact your pharmacist or doctor.
  • Ambroxol Hydrochloride Syrup Expired

  • An adverse condition is unlikely to occur from taking a single dose of expired Ambroxol Hydrochloride Syrup. However, for better advice, please speak with your primary health practitioner or pharmacist or if you feel unwell or sick. In treating your prescription conditions, expired medication can become ineffective. It is necessary to not use expired medications to be on the safe side. If you have a chronic condition that regularly needs medication such as heart failure, strokes, and life-threatening allergies, you are much better to stay in contact with your primary health care provider so that you can have a new supply of drugs that are not expired.
  • Interactions with other drugs

  • If you are taking, have recently taken, or expect to take any medications, dietary supplements, or herbal products, be sure to tell your doctor and/or pharmacist.
  • Extreme interactions where concomitant use should be avoided are not currently known. However, if you are taking any antibiotics, warn your doctor or pharmacist since ambroxol will increase the amount of antibiotic penetration.
  • Ambroxol vs Acetylcysteine

    Ambroxol Acetylcysteine
    Molar mass: 378.1028 g/mol Molar mass: 163.1951 g/mol
    Formula: C13H18Br2N2O Formula: C5H9NO3S
    Other names: Ambroxol hydrochloride Other names: N-acetylcysteine; N-acetyl-L-cysteine; NALC; NAC
    Used to treat the respiratory related diseases associated with viscid Used to treat overdose of paracetamol, and to loosen the thick mucus

    Frequently Asked Questions:

    This drug is used for the symptomatic treatment of tracheobronchitis, an infection that induces tracheal (windpipe) and pulmonary airway inflammation. Ambroxol in this case relieves the patient from an excessive cough and thick sputum.
    Yes, In some patients with acute sore throat, sucking lozenges containing 20 mg or 30 mg of ambroxol hydrochloride has positive results and beneficial pain-relieving effect, superior to that obtained by sucking a placebo lozenge.
    Side effects are Gastrointestinal disorders: nausea, vomiting, diarrhoea, dyspepsia, dry mouth or throat, oral or pharyngeal hypoesthesia, stomach pain, heartburn, dysgeusia.
    The minimum dosage to be taken three times a day is 30 mg (one tablet). YES, these tablets can be taken with or without food.
    Ambroxol hydrochloride Cyathus contains a small volume, less than 100 mg per single dose, of ethanol (alcohol).

    Citations:

  • Ambroxol, https://europepmc.org/article/med/3322865
  • Properties of Ambroxol, https://www.sciencedirect.com/science/article/abs/pii/0891584994901309