What is Adapalene ?

Adapalene is a topical retinoid of the third generation, that is commonly used in the treatment of mild-moderate acne and is also used off-label for the treatment of keratosis pilaris and other skin conditions. It is successful against cases of acne where there are prevailing comedones.

Adapalene Uses

For the treatment of acne, this drug is used. The number and incidence of acne pimples can be decreased and fast healing of pimples that grow can be encouraged. Adapalene is in a family of drugs known as retinoids. It works by controlling the growth of the cell and reducing swelling and inflammation.

How to make usage of Adapalene Gel?

  • Before taking this drug, read and follow all the instructions on the product packaging if you are using the over-the-counter product for self-treatment. Consult your doctor if you have any queries. If this drug has been prescribed by your physician, use it as directed.
  • Use this drug as recommended by your doctor or in a box of drugs, usually once a day at bedtime. Clean the infected skin gently with a mild or soapless cleanser before using, and pat dry.
  • Clean your hands before and after using this drug whether you are using a gel, cream, or lotion. To add a small amount of medicine to a thin sheet, use your fingertips. Unwrap the swab and add a thin layer to the infected region if you are using a medicated swab (s).
  • Using this drug just on your skin. Stop having this drug on your lips or in your eyes. Do not refer to the area of your inner lip or the nose/mouth inside. Flush it with massive quantities of water if this drug gets into your eyes. If eye pain occurs, call your doctor. Do not refer to areas cut, scraped or sunburned, or to eczema-affected skin (a skin condition).
  • Your acne may appear worse within the first few weeks of using adapalene, as the drug works on pimples forming within the skin. It can take 8 to 12 weeks for this drug to produce results.
  • To get the most benefit from it, use this drug occasionally. To help you remember, use it each day at the same time. Do not use or use a greater quantity more often than guided. Your skin won't improve more easily and your risk of side effects (such as redness, peeling, or pain) will increase.
  • This drug is available in various strengths and shapes (such as gel, cream, lotion). The right form of the drug to use depends on the condition of your doctor.
  • Since this drug gets absorbed through the skin it can affect an unborn baby, this medication should not be handled by women who are pregnant or who may become pregnant.

Adapalene Side Effects

  • Right after applying the drug, a brief warmth or stinging sensation may occur. During the first 2-4 weeks of using the drug, skin redness, dryness, scratching, scaling, mild burning, or worsening of acne can occur. With continued use, these effects typically decrease. Inform the doctor or pharmacist immediately if any of these symptoms continue or worsen. Your doctor may want you to reduce the frequency of use of adapalene, adjust its power, or avoid using it.
  • If you have been directed to use this drug by your doctor, note that he or she has found that the advantage is greater than the risk of side effects. There are no side effects for many people who take this drug.
  • If any of these unlikely but severe side effects arise, inform your doctor immediately: very red/irritated skin, an extreme burning feeling, redness and watering of the eyes (conjunctivitis), swelling of the eyelids, discoloration of the skin.
  • It is unusual to experience a very serious allergic reaction to this drug. However, if you experience any signs of any kind of serious allergic reactions, including rashes, itching/swelling (especially of the face/tongue/throat), extreme dizziness, difficulty breathing, get medical assistance immediately.
  • It is not a full list of side effects that may be likely. Contact your pharmacist if you notice other effects that are not listed above.


  • Tell your doctor or pharmacist whether you are allergic to adapalene or to vitamin A-related medicines (other retinoids such as isotretinoin) or if you have any other allergies before using adapalene. There may be some inactive ingredients in this substance that might cause allergic reactions or other problems.
  • Inform your doctor or pharmacist of your medical history, particularly of eczema, before using this drug.
  • You can become more responsive to the sunlight exposure with this drug. In the sun, limit your time. Stop booths and sun lamps for tanning. The skin can also be irritated by weather extremes, such as wind or cold. Use sunscreen every day and, when outside, wear protective clothing. If you get sunburned or you have skin blisters/redness, tell your doctor straight away. Before using adapalene, wait until the skin has fully healed from sunburn.
  • When using this item, avoid electrolysis, waxing, and chemical depilatories for hair removal in the treated areas.
  • If you have recently used sulfur, resorcinol, or salicylic acid-containing products, use adapalene with caution.
  • Since this drug is absorbed through the skin and can affect an unborn baby, this medication should not be handled by women who are pregnant or who may become pregnant.
  • If you are pregnant or want to become pregnant, inform your doctor. When using adapalene, you should not become pregnant. An unborn baby can be affected by Adapalene. Speak to your doctor straight away about the dangers and advantages of this drug if you become pregnant.
  • Whether this medication passes into breast milk is not understood. Before breastfeeding, consult the doctor.

Drug Interactions

  • It can change the way your medicines function or increase the risk of severe side effects. Keep a list and show it to your doctor and pharmacist of all the medications you are using (including prescription/nonprescription medicines and herbal products). Without your doctor's permission, never start taking this on your own, stopping, or adjust the dosage of any medication.
  • Products which contains alpha-hydroxy acids, hair perming solutions, products containing glycolic acid, products containing alcohol/lime/menthol (such as astringents, toners, shaving lotions), medicated or abrasive soaps and cleansers, soaps and cosmetics are some of the products that may interact with this medication


Cosmetics can be used, but before applying the drug, thoroughly clean the skin. Your acne can get worse with some cosmetics and soaps. It is likely that moisturizers are safe to use. Check the label for "non-comedogenic" or "non-acnegenic" when purchasing cosmetics, moisturizers, or other skin care items. These products are unlikely to exacerbate the acne. Ask your doctor or pharmacist which items you can use that are healthy. Mind, dirt does not cause acne. It can irritate your skin and exacerbate acne by washing your skin too much or too vigorously.

Missed Dose

If you are consuming this medication on a daily/regular basis and you forget to take a dose, take it as soon as you recall it. If it is near to the time of the next dose, don’t take the skipped dose. Do Not double the dose to recover/cope with the missed or forgotten dose.

Over Dose

If overdosed, this drug can be harmful. When someone has taken an overdose some extreme signs such as passing out or respiratory problems can happen.


Store it far away from light and moisture at room temperature. Stop being frozen. Various formulations of this drug can have different criteria for storage. Read the label of the box or ask your pharmacist about the criteria for storage of the product you are using. Preparations for gel are flammable. Do not expose them to sources of heat or fire. Do not smoke when using it. Keep all medication away from children. Unless told to do so, do not flush drugs down the toilet or dump them into a drain. When it gets expired or no longer needed, properly discard this product.

Adapalene vs Retinol



Formula: C28H28O3 Formula: C20H30O
Molar mass: 412.52 g/mol Molar mass: 286.45 g/mol
Is a topical retinoid Also known as vitamin A/td>
Used in the treatment of mild-moderate acne Used as a dietary supplement.

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Frequently Asked Questions

What does Adapalene do to your skin?

For the treatment of acne, this drug is used. The number and incidence of acne pimples can be decreased and fast healing of pimples that grow can be encouraged. Adapalene belongs from a family of drugs known as retinoids. It works by controlling the growth of cells and reducing swelling and inflammation.

Does Adapalene remove dark spots?

Adapalene 0.1 percent gel (Differin) is an anti-inflammatory OTC treatment that helps stop the formation of acne comedones. Dermatologists might suggest balancing out the skin complexion of an individual and lightening of the dark spots in addition to preventing breakouts of acne.

What is the Adapalene gel used for?

For the treatment of acne, Adapalene is used. Adapalene is in a family of drugs called compounds similar to retinoids. It functions by preventing the development of pimples under the skin's surface.

Is Adapalene better than retinol?

Adapalene has a somewhat different function than retinol/retinoic acid. It slows down the hyperkeratinization process, or excessive growth in the lining of the pores, and desensitizes inflammation of the skin. Studies suggest that Adapalene has fewer side effects that are less irritating than other retinoids, which is why it is so ideal for acne.

Disclaimer: The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not be treated as a replacement for physical medical consultation or advice. We do not guarantee the accuracy and the completeness of the information so provided. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company. We do not take any responsibility for the consequences arising out of the aforementioned information and strongly recommend you for a physical consultation in case of any queries or doubts.