Acute Rheumatic Fever: Signs, Causes, and Treatment

Acute rheumatic fever is a rare but serious condition that can affect individuals, particularly children, following an untreated streptococcal infection like strep throat. The body's immune response to the infection can lead to inflammation in various organs, causing symptoms such as joint pain and fever. It is crucial to seek medical attention promptly to prevent complications and manage the condition effectively. 

Symptoms of Acute Rheumatic Fever

Acute rheumatic fever symptoms can include fever, joint pain and swelling, chest pain, shortness of breath, skin rash, and jerky body movements. Patients may also experience fatigue, weakness, and a feeling of overall illness. It is important to seek medical attention if you experience any of these symptoms, especially after a strep throat infection.

  • Sudden joint pain and swelling, especially in the knees, elbows, or wrists, can be a symptom of acute rheumatic fever.
  • Unexplained fever and fatigue that doesn't go away even with rest are common signs of acute rheumatic fever.
  • Skin rashes with a characteristic "rash like a map" appearance may develop in individuals with acute rheumatic fever.
  • Shortness of breath, chest pain, and palpitations can occur due to inflammation of the heart muscle during acute rheumatic fever.
  • Sudden jerky movements or uncontrollable twitching of the hands, feet, or face may be indicative of acute rheumatic fever affecting the nervous system.

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Causes of Acute Rheumatic Fever

When the body's immune system fights off the bacterial infection, it can mistakenly attack healthy tissues, leading to inflammation in various parts of the body.  This can result in the characteristic symptoms of acute rheumatic fever, affecting the heart, joints, skin, and brain.

  • Acute rheumatic fever is primarily caused by untreated or inadequately treated streptococcal infections, particularly group A Streptococcus bacteria.
  • Genetic predisposition can increase the risk of developing acute rheumatic fever in individuals with a family history of the condition.
  • Inadequate access to healthcare and delayed treatment of streptococcal infections can contribute to the development of acute rheumatic fever.
  • Environmental factors, such as overcrowded living conditions and poor sanitation, can create an environment conducive to the spread of streptococcal infections that may lead to acute rheumatic fever.

Types of Acute Rheumatic Fever

There are two main types of acute rheumatic fever: cardiac and non-cardiac. Cardiac symptoms involve the heart and can lead to complications such as inflammation of the heart valves. Non-cardiac symptoms can affect various parts of the body like the joints, skin, and brain. Both types can cause fever, joint pain, and other symptoms that require prompt medical attention.

  • Sydenham's chorea is a rare type of acute rheumatic fever characterized by sudden, uncontrolled movements of the limbs, face, and trunk, often accompanied by emotional instability and muscle weakness.
  • Erythema marginatum presents as painless, pinkish, or red skin rashes with well-defined borders that typically appear on the trunk and inner surfaces of the arms and thighs in patients with acute rheumatic fever.
  • Subcutaneous nodules are firm, painless lumps that develop under the skin, usually over bony prominences such as the elbows, knees, and knuckles, as a manifestation of acute rheumatic fever.

Risk Factors

Acute rheumatic fever risk factors include untreated strep throat infections, particularly in children aged 5-15, living in overcrowded conditions, poor sanitation, and inadequate access to healthcare. 

  • A history of untreated or inadequately treated streptococcal throat infections increases the risk of developing acute rheumatic fever.
  • Living in crowded or unsanitary conditions can elevate the likelihood of contracting streptococcal infections, which can lead to acute rheumatic fever.
  • Children and young adults are at higher risk for acute rheumatic fever, especially if they have not received appropriate treatment for streptococcal infections.
  • Genetic factors may predispose individuals to developing acute rheumatic fever, particularly if there is a family history of the condition.

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Diagnosis of Acute Rheumatic Fever

The doctor may also listen for a heart murmur and order an echocardiogram to assess heart damage.  Prompt diagnosis is crucial to prevent complications and guide treatment.  If you have symptoms like joint pain, fever, or chest pain, seek medical help.

  • Throat culture to identify group A streptococcal infection, which is the underlying cause of acute rheumatic fever.
  • Blood tests to check for elevated levels of certain markers, such as anti-streptolysin O (ASO) titer or anti-DNAse B, which indicate recent streptococcal infection.
  • Echocardiogram to assess heart function and detect any abnormalities, such as inflammation of the heart valves, a common complication of acute rheumatic fever.
  • Electrocardiogram (ECG) to monitor the electrical activity of the heart and identify any irregularities or signs of damage.

Treatment for Acute Rheumatic Fever

Treatment for acute rheumatic fever typically involves antibiotics to treat the underlying streptococcal infection, anti-inflammatory medications to reduce inflammation and pain, and sometimes corticosteroids to manage severe symptoms. 

Bed rest and plenty of fluids are also recommended. It is important to complete the full course of antibiotics and follow up with your healthcare provider regularly to prevent complications and recurrence.

  • Antibiotics, such as penicillin or erythromycin, are commonly prescribed to treat acute rheumatic fever to eradicate the streptococcal bacteria causing the infection and prevent further complications.
  • Nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen or aspirin are used to reduce inflammation, pain, and fever associated with acute rheumatic fever, helping to alleviate symptoms and improve comfort.
  • Corticosteroids may be recommended in severe cases of acute rheumatic fever to suppress inflammation and reduce the risk of heart complications, particularly in patients with carditis.
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Frequently Asked Questions

What are the common signs of acute rheumatic fever?

Common signs of acute rheumatic fever include fever, joint pain and swelling, rash, chest pain, and shortness of breath.

What are the recommended do's and don'ts for managing acute rheumatic fever?

Do's: Complete prescribed antibiotics, rest, follow-up appointments. Don'ts: Skip medications, engage in strenuous activities, forget to monitor symptoms.

Can acute rheumatic fever lead to other health issues?

Yes, acute rheumatic fever can lead to complications like rheumatic heart disease, which can affect the heart valves and lead to serious heart problems.

What are the best ways to manage acute rheumatic fever?

Treatment includes antibiotics for strep infection, anti-inflammatory medications to reduce inflammation and symptoms, and long-term antibiotics to prevent recurrence.

Are there any signs that acute rheumatic fever might recur after treatment?

Yes, joint pain, fever, rash, and heart-related symptoms like chest pain or shortness of breath may indicate a recurrent acute rheumatic fever after treatment.

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