Written by Medicover Team and Medically
Reviewed by
Dr K Suresh
Common Side Effects of Lamotrigine
Lamotrigine is commonly prescribed for epilepsy and bipolar disorder. While effective, it may cause side effects. Understanding these helps in managing them and making informed treatment choices.
What is Lamotrigine?
Lamotrigine (brand name: Lamictal) is an anticonvulsant used to control seizures and stabilize mood. The starting dose is usually 50 mg, but it varies depending on individual needs. It may also be used off-label for conditions like borderline personality disorder and some anxiety disorders.
It’s known for having fewer side effects than many other mood stabilizers, but close monitoring is still essential, especially when starting treatment.
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Lamotrigine helps control brain activity by blocking sodium channels and reducing glutamate release. This helps prevent seizures and mood swings. Its impact on brain chemistry also explains some of its side effects.
Cognitive Side Effects
Some people may notice changes in thinking or memory:
Memory issues: Difficulty recalling information
Concentration problems: Trouble focusing on tasks
Mental fog: Feeling mentally sluggish or unclear
These effects may be temporary or persist. Talk to your doctor if they interfere with daily life.
Sexual Side Effects
Though less common, lamotrigine may impact sexual health:
Reduced libido
Erectile dysfunction
Difficulty reaching orgasm
These may affect relationships or emotional well-being. If concerned, speak with your doctor about managing these side effects.
Long-Term Side Effects
With prolonged use, some long-term effects may appear:
Weight gain: Less common but possible
Skin rashes: Watch for serious reactions like Stevens-Johnson syndrome
Bone health: Long-term use may reduce bone density
Regular check-ups can help detect and manage these risks early.
Rare but Serious Side Effects
Some rare side effects need urgent medical attention:
Stevens-Johnson Syndrome: Severe rash, blisters, or skin peeling
Suicidal thoughts: Monitor for changes in mood or behavior
Aseptic meningitis: Symptoms include headache, stiff neck, light sensitivity, nausea
Report any of these signs to your doctor immediately.
Caffeine: Might reduce the calming effects of the drug
Limiting these can help the medication work more effectively.
Managing Side Effects
If you notice any side effects, don’t stop the medication on your own. Talk to your doctor, they may adjust your dose or suggest lifestyle changes like diet or exercise to help manage symptoms.
Lamotrigine Dosage
Dosage is personalized. Typically:
Initial dose: 25–50 mg/day to start slowly
Maintenance dose: 100–400 mg/day based on your condition
Your doctor will adjust your dose based on how well you respond and whether side effects occur.
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Lamotrigine is effective for many people with epilepsy or bipolar disorder. Knowing about its possible side effects, from memory issues to rare skin reactions, can help you stay informed and take action early.
Regular doctor visits and open conversations are key. With the right management, you can get the benefits of lamotrigine while minimizing its risks.
Frequently Asked Questions
Yes, skin rash can be a sign of a severe allergic reaction like Stevens-Johnson Syndrome. It requires immediate medical attention, especially if it’s accompanied by fever or blistering.
Lamotrigine may cause insomnia or excessive sleepiness in some people. If sleep disturbances persist, consult your doctor to adjust the dosage or timing.
Most mild side effects improve within a few days to weeks. However, severe side effects may require discontinuing the medication under medical supervision.
Yes, lamotrigine can interact with other drugs like valproate or oral contraceptives. Always inform your healthcare provider about all medications and supplements you're taking.
Lamotrigine tablets are used to treat seizures in epilepsy and to stabilize mood in bipolar disorder. They help prevent mood swings and seizures by modulating the activity of neurotransmitters in the brain.
Lamotrigine can be taken at any time of the day, but it is often recommended to take it at the same time each day to maintain consistent levels in the body. Whether to take it at night or during the day may depend on individual tolerance and side effects.