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Papaverine

Papaverine

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By Medicover Hospitals / 01 March 2021
Home | Medicine | Papaverine
  • Papaverine is a vasodilator, which means it relaxes the smooth muscles in your blood vessels, allowing them to dilate more quickly (widen). This decreases blood pressure and makes it easier for blood to flow into the veins and arteries. An alkaloid found in opium that is structurally and pharmacologically different from the other opium alkaloids. It's a smooth muscle relaxant with a direct action that's used to treat impotence and as a vasodilator, especially for cerebral vasodilation. Its pharmacological actions are unclear, but it appears to be able to inhibit phosphodiesterases and may have direct effects.
  • Papaverine 60 mg Injections are used to treat erectile dysfunction in men (the failure to sustain an erection long enough for sexual activity). It assists in the expansion of blood vessels and the increase in blood flow.
    1. Papaverine Uses
    2. Papaverine Side effects
    3. Precautions
    4. Papaverine vs Drotaverine
    5. Frequently Asked Questions
    6. Citations

    Papaverine Uses:

  • Papaverine is used to treat a number of disorders that cause smooth muscle spasms. This can include chest pain, circulation issues, a heart attack, or stomach or gallbladder problems. Papaverine should not be administered into the penis and should not be used to treat erectile dysfunction (impotence). This procedure has resulted in painful or prolonged erections, which may lead to surgery. In patients with circulatory disorders, papaverine is used to improve blood flow. It works by relaxing blood vessels, allowing more blood to flow to the heart and across the body.
  • Papaverine 60 mg injections are prescribed by the doctor, which must not be self-administered. Since long-term use of this drug can lead to dependency, it should only be used for a long time if your doctor recommends it.
  • Papaverine Side effects:

  • Some of the common side effects of Papaverine are:
    • Nausea
    • Upset stomach
    • Loss of appetite
    • Constipation
    • Diarrhea
    • Headache
    • Drowsiness
    • Dizziness
    • Spinning sensation
    • Skin rash
    • Increased sweating
    • Tiredness and lack of energy
  • Some of the serious side effects of Papaverine are:
    • Dark urine
    • Jaundice
    • Numbness
    • Muscle weakness
    • Irregular heartbeat
    • Anxiety
    • Blurred vision
  • If you have any of these serious symptoms, see your doctor right away. In any case, if you encounter any side effects from Papaverine, try to prevent it. By seeing the issues, a doctor recommended you to take the drugs, and the benefits of this drug outweigh the side effects.
  • Precautions:

  • Before taking Papaverine talk with your doctor if you are allergic to it or any other medications. The product may contain some inactive ingredients which can cause some serious allergic reactions or some other problems. Before taking Papaverine talk with your doctor if you are having any medical history such as Heart disease, High blood pressure, Glaucoma and Liver disease. Papaverine should be strictly avoided if a person is having a serious heart condition such as “ AV block.”
  • How to take Papaverine?

  • Papaverine is available as a tablet and an extended-release (long-acting) capsule for oral administration. Three to five times a day, at evenly spaced intervals, the tablet is usually taken. Every 8-12 hours, the extended-release capsule is taken. The extended-release capsules should not be crushed, chewed, or split. Follow the directions on your prescription label carefully, and if you have any questions, ask your doctor or pharmacist for clarification. Follow the directions for taking papaverine. It's possible that papaverine is addictive. Do not take higher doses, take it more frequently, or for a longer period than prescribed by your doctor.
  • Benefits of Papaverine

  • The blood vessels in your penis relax as you take papaverine. When sexually aroused, this causes blood to rush through the penis and cause an erection. If you are sexually aroused, this drug can just help you get an erection. It is delivered by a doctor or nurse as an injection and should not be self-administered. To get the most value, carefully follow your doctor's instructions.
  • Missed Dose

  • Your body will not be harmed if you skip one or two doses of Papaverine. There is no problem with the missed dose. However, if you do not take your medicine on time, it will not work. A sudden chemical change in your body can occur if you miss a dose. If you miss a dose, your doctor can recommend that you take it as soon as possible.
  • Overdose

  • In case of an overdose, the patient should consult a doctor immediately. Restlessness, confusion, and dizziness are typical overdose symptoms. The severity of the symptoms can lead to measuring gastric lavage.
  • Warnings for some serious health conditions

  • Pregnancy: Using papaverine while pregnant could be dangerous. Animal studies have shown harmful effects on the developing baby, despite the lack of human studies. Before prescribing it to you, your doctor will consider the benefits as well as any potential risks. Please seek medical advice.
  • Breastfeeding: There is no information on the use of Papaverine 60mg Injection while breastfeeding. Please seek medical advice.
  • Storage

  • Direct contact with heat, air and light may damage your medicines. Exposure to medicine may cause some harmful effects. The medicine must be kept in a safe place and out of children’s reach. Mainly the drug should be kept at room temperature between 68ºF and 77ºF (20ºC and 25ºC).
  • Papaverine vs Drotaverine

    Papaverine
    Drotaverine
    Papaverine is a vasodilator, which means it relaxes the smooth muscles in your blood vessels, allowing them to dilate more quickly (widen). Drotaverine (INN, also known as drotaverine) is an antispasmodic drug similar to papaverine in structure. Drotaverine is a phosphodiesterase 4 inhibitor that has no anticholinergic properties.
    Papaverine is used to treat a number of disorders that cause smooth muscle spasms. Drotaverine is an important treatment for twitches or spasms of the smooth muscles of the stomach and heart.
    Some of the common side effects of Papaverine are:
    • Nausea
    • Upset stomach
    • Loss of appetite
    • Constipation
    • Diarrhea
    Some of the common and serious side effects of Drotaverine are:
    • Nausea
    • Vomiting
    • Dry mouth
    • Change in pulse rate
    • Dizziness

    Frequently Asked Questions:

    Papaverine is used to treat a number of disorders that cause smooth muscle spasms. This can include chest pain, circulation issues, a heart attack, or stomach or gallbladder problems.
    Antispasmodics are a class of drugs that include papaverine. These relax the small muscles inside the walls of blood vessels, which helps to treat blood vessel muscle spasms.
    As directed by your doctor, inject the medication slowly and directly into the base of the penis with a sterile needle. It is not advised to inject papaverine only under the surface. Although you may experience tingling in the tip of your penis, the injection is generally painless.
    Papaverine is a vasodilator. It relaxes blood vessels, allowing blood to flow more freely into them. It's used to treat blood vessel spasms caused by such conditions. This drug can also be used to treat spasms in the urinary tract, gallbladder, or stomach.
    Papaverine affect last for 4 hours. Patients should be more cautious and in case of any possible side effects, they should consult a doctor.
    Papaverine is an opium alkaloid antispasmodic medication used to treat visceral spasms and vasospasms (especially those affecting the intestines, heart, or brain), as well as erectile dysfunction on occasion.

    Citations:

  • Papaverine, https://www.sciencedirect.com/science/article/abs/pii/0024320571900865
  • Treatment of cerebral vasospasm with intra-arterial papaverine, https://thejns.org/view/journals/j-neurosurg/77/6/article-p848.xml