What is Papaverine?

Papaverine is a vasodilator, a medication that relaxes the smooth muscles in your blood vessels, causing them to widen. This action decreases blood pressure and facilitates blood flow into veins and arteries. 

It is an alkaloid found in opium but is structurally and pharmacologically distinct from other opium alkaloids. Papaverine acts as a smooth muscle relaxant and is used to treat conditions such as impotence and as a vasodilator, particularly for cerebral vasodilation.


Papaverine Uses

Papaverine is used to treat various disorders that cause smooth muscle spasms, including chest pain, circulation issues, heart attacks, and stomach or gallbladder problems. It improves blood flow by relaxing blood vessels, thus enhancing blood supply to the heart and throughout the body. Although previously used for erectile dysfunction, it is no longer recommended for this purpose due to the risk of painful or prolonged erections.

Note: Papaverine injections should only be administered by a healthcare professional and should not be self-administered. Long-term use can lead to dependency and should be managed under strict medical supervision.

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Papaverine Side Effects

Common Side Effects:

  • Nausea
  • Upset stomach
  • Loss of appetite
  • Constipation
  • Diarrhea
  • Headache
  • Drowsiness
  • Dizziness
  • Spinning sensation
  • Skin rash
  • Increased sweating
  • Tiredness and lack of energy

Serious Side Effects:

  • Dark urine
  • Jaundice
  • Numbness
  • Muscle weakness
  • Irregular heartbeat
  • Anxiety
  • Blurred vision

If you experience any serious side effects, contact your doctor immediately.


Precautions

Before taking Papaverine, inform your doctor if you have any allergies to it or other medications. Discuss your medical history, especially if you have heart disease, high blood pressure, glaucoma, or liver disease. Papaverine should be strictly avoided if you have a serious heart condition such as AV block.


How to Take Papaverine

Papaverine is available as a tablet and an extended-release capsule for oral administration.

Dosage Instructions:

  • Tablets: Usually taken 3-5 times a day at evenly spaced intervals.
  • Extended-Release Capsules: Taken every 8-12 hours. Do not crush, chew, or split the capsules.

Follow your prescription label instructions carefully. If you have any questions, ask your doctor or pharmacist. Avoid taking higher doses, more frequently, or for a longer period than prescribed.


Benefits of Papaverine

Papaverine helps relax blood vessels in the penis, allowing blood to flow more easily, which aids in achieving an erection when sexually aroused. It is administered by a healthcare professional and should not be self-administered. Follow your doctor’s instructions for optimal benefits.


Missed Dose

Missing one or two doses of Papaverine usually does not cause harm. However, for the medication to be effective, take it as prescribed. If you miss a dose, take it as soon as possible, but do not double the dose to make up for the missed one.


Overdose

In case of overdose, seek immediate medical attention. Symptoms may include restlessness, confusion, and dizziness. Severe symptoms might require gastric lavage.


Warnings for Serious Health Conditions

Pregnancy: Using Papaverine during pregnancy could be harmful. Animal studies have shown adverse effects on the developing baby, and although human studies are lacking, potential risks should be carefully considered by your doctor.

Breastfeeding: It is not known whether Papaverine is excreted in breast milk. Consult your doctor before using it while breastfeeding.

Storage

Store Papaverine at room temperature between 68ºF and 77ºF (20ºC and 25ºC), away from heat, air, and light. Keep the medication out of reach of children.

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Papaverine vs Drotaverine

Papaverine

Drotaverine

Vasodilator that relaxes smooth muscles in blood vessels

Antispasmodic drug similar to papaverine

Used to treat smooth muscle spasms, chest pain, circulation issues

Treats spasms of the smooth muscles of the stomach and heart

Common side effects: nausea, upset stomach, loss of appetite, constipation, diarrhea

Common side effects: nausea, vomiting, dry mouth, change in pulse rate, dizziness

Before taking Papaverine, consult your doctor. If you experience any side effects or health issues, seek medical attention immediately. Follow your prescription and doctor's advice for the best results, and always carry your medications while traveling to avoid emergencies.


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Frequently Asked Questions

1. What is the drug papaverine used for?

Papaverine is used to treat a number of disorders that cause smooth muscle spasms. This can include chest pain, circulation issues, a heart attack, or stomach or gallbladder problems.

2. What class of drug is papaverine?

Antispasmodics are a class of drugs that include papaverine. These relax the small muscles inside the walls of blood vessels, which helps to treat blood vessel muscle spasms.

3. Where do you inject papaverine?

As directed by your doctor, inject the medication slowly and directly into the base of the penis with a sterile needle. It is not advised to inject papaverine only under the surface. Although you may experience tingling in the tip of your penis, the injection is generally painless.

4. What is papaverine injection?

Papaverine is a vasodilator. It relaxes blood vessels, allowing blood to flow more freely into them. It's used to treat blood vessel spasms caused by such conditions. This drug can also be used to treat spasms in the urinary tract, gallbladder, or stomach.

5. How long does papaverine last?

Papaverine affect last for 4 hours. Patients should be more cautious and in case of any possible side effects, they should consult a doctor.

6. Is papaverine an alkaloid?

Papaverine is an opium alkaloid antispasmodic medication used to treat visceral spasms and vasospasms (especially those affecting the intestines, heart, or brain), as well as erectile dysfunction on occasion.


Disclaimer: The information provided herein is accurate, updated and complete as per the best practices of the Company. Please note that this information should not be treated as a replacement for physical medical consultation or advice. We do not guarantee the accuracy and the completeness of the information so provided. The absence of any information and/or warning to any drug shall not be considered and assumed as an implied assurance of the Company. We do not take any responsibility for the consequences arising out of the aforementioned information and strongly recommend you for a physical consultation in case of any queries or doubts.

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