Keflex (cephalexin) is an antibiotic in the cephalosporin class. It fights bacteria in the body and is prescribed to treat bacterial infections such as upper respiratory infections, ear infections, skin infections, urinary tract infections, and bone infections.

Keflex is suitable for adults and children over one year of age and is available as a syrup (Keflex syrup) or tablets (Keflex 100 mg).

Keflex Tablet Uses

Keflex treats a wide range of bacterial infections by preventing bacterial growth. It is ineffective against viral infections (like the common cold or flu). Misusing antibiotics can reduce their effectiveness.

Commonly Used For:

  • Respiratory tract infections
  • Skin infections
  • Ear infections
  • Urinary tract infections (UTIs)

Quick Highlight of Its Benefits:

  • Effective against many gram-positive bacteria
  • Well-tolerated with a broad safety profile
  • Often prescribed when penicillin allergies are present

Conditions Keflex used to Treat:

  • Strep throat and tonsillitis
  • Skin and soft tissue infections (e.g., cellulitis)
  • Urinary tract infections
  • Otitis media (middle ear infection)
  • Bone infections (osteomyelitis)

How Does Keflex Work?

Keflex (cephalexin) works by:

  • Inhibiting bacterial cell wall synthesis
  • Binds to penicillin-binding proteins (PBPs) in bacteria
  • Causes the bacterial cell wall to weaken and rupture

Simply put, it "punches holes" in the bacterial cell wall, causing the bacteria to die.

How to Use Keflex

  • Administration: Take orally, with or without food, every 6 to 12 hours.
  • Suspension: Shake well before each dose and use a measuring device to ensure the correct dose. Do not use a regular spoon.
  • Dosage: Determined by medical condition and response to treatment. For children, the dosage is weight-based.

For the best results, take this antibiotic at regular intervals and complete the full prescribed course even if symptoms disappear. Stopping too soon may cause the infection to return.

Dosage of Keflex

Typical Dosage Instructions (Follow Doctor's Advice):

  • Adults: 250-500 mg every 6 hours, or 500 mg every 12 hours
  • Duration: Typically 7-14 days
  • Children: Dose based on body weight (25-50 mg/kg/day) divided into multiple doses
  • Can be taken with or without food. Taking with food may reduce stomach upset.

Overdose

If an overdose is suspected, seek medical advice immediately. Never take more than prescribed.

Missed Dose

If a dose is missed, take it as soon as you remember. If it is close to the next dose, skip the missed dose. Do not double the dose.

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Keflex Side Effects

Common side effects include:

  • Abdominal or stomach pain
  • Blistering, peeling of the skin
  • Chills, cough
  • Dark urine, diarrhea
  • Dizziness, fever, tiredness, weakness
  • Headache, itching, rash
  • Joint or muscle pain
  • Loss of appetite, nausea, vomiting

Serious but Rare Side Effects:

  • Severe allergic reactions (anaphylaxis)
  • C. difficile-associated diarrhea
  • Liver dysfunction
  • Seizures (in high doses or kidney failure)

Report any severe rash, persistent diarrhea, or allergic symptoms to your doctor immediately.

Precautions and Warnings

  • Allergies: Inform your doctor if you are allergic to cephalexin, penicillins, or other cephalosporins.
  • Medical History: Inform your doctor if you have kidney disease or stomach/intestinal disease (like colitis).
  • Diabetes: The liquid form may contain sugar; consult your doctor or pharmacist.
  • Pregnancy: Discuss the risks and benefits with your doctor before taking during pregnancy.
  • Breastfeeding: This medication may pass into breast milk. Consult your doctor before breastfeeding.

Use With Caution In:

  • Patients with kidney disease
  • Pregnant or breastfeeding women (only under doctor's advice)
  • People with a history of gastrointestinal disease

Are There Any Age Restrictions for Using Keflex?

  • Safe for infants >1 year, children, adults, and elderly
  • Pediatric dosing must be weight-based

Alcohol or Food Interactions

Food:

  • No significant food interactions
  • Taking with food may help reduce stomach discomfort

Alcohol:

  • No direct interaction, but alcohol may reduce immune response
  • Best to avoid excess alcohol during treatment

Possible Interactions with Other Medications.

  • Drug Interactions: These can affect how medications work or increase side effects. Keep a list of all products you use and share it with your doctor and pharmacist.
  • Laboratory Tests: May interfere with certain tests, like the Coombs' test and some urine glucose tests.

May Interact With:

  • Metformin - risk of low blood sugar
  • Probenecid - increases cephalexin levels
  • Live bacterial vaccines - may become less effective
  • Anticoagulants (warfarin) - may increase bleeding risk

Supplements/Herbals:

  • No major issues, but always consult your doctor or pharmacist

How Should Keflex Be Stored?

Recommended Storage:

  • Tablets/capsules: Store at room temperature (20-25°C or 68-77°F)
  • Liquid suspension: Refrigerate, and discard after 14 days

What Happens If Not Stored Properly?

  • Liquid may spoil or become ineffective
  • Tablets may degrade in heat or moisture

Keflex vs. Amoxicillin

Keflex Amoxicillin
Antibiotic class: Cephalosporin Antibiotic class: Penicillin-like antibiotics
Treats a wide range of bacterial infections Treats middle ear infections, strep throat, pneumonia, skin infections, and UTIs
Works by fighting bacteria in the body Works by stopping the growth of bacteria in the body

References

Indications for Keflex
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Frequently Asked Questions

No, these drugs are classified as different types of antibiotics. Amoxicillin is a penicillin-type antibiotic, whereas Keflex is a cephalosporin antibiotic.

Penicillin and Keflex (cephalexin) are antibiotics used to treat bacterial infections. Keflex and penicillin belong to separate drug classes. Penicillin is a penicillin-type antibiotic, and Keflex is a cephalosporin antibiotic.

Keflex belongs to the antibiotic class known as cephalosporins. Keflex is a first-generation cephalosporin that works primarily against gram-positive bacteria.

Both antibiotics are effective against the organisms they are designed to treat when properly dosed. Cephalexin's organism coverage makes it effective in conditions where amoxicillin is ineffective, such as mastitis and bone and joint infections.

Keflex is used for treating respiratory tract infections caused by susceptible Streptococcus pneumoniae and Streptococcus pyogenes isolates.

Peak concentrations are reached 1 hour after dosing; however, it takes up to 48 hours for infection-related symptoms to start working.

Because of inadequate antimicrobial coverage of the major organisms, penicillin, erythromycin (Suprax), and first-generation cephalosporins such as cephalexin (Keflex, Keftab) are not recommended for treating acute sinusitis.

Every day, four times: once in the morning, once around midday, once in the early afternoon, and once in the evening. These times should ideally be about 4 hours apart, such as 8 a.m., midday, 4 p.m., and 8 p.m.


Disclaimer: The information provided is accurate and up-to-date to the best of our knowledge. However, it should not be considered a substitute for medical advice or consultation. We do not guarantee its completeness or accuracy. The absence of specific warnings does not mean a medicine is safe for all users. We are not responsible for any outcomes based on this information and strongly recommend consulting a doctor for any medical concerns or questions.

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